Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog

Buchholz, Daniel R.; Paul, Bindu D.; Fu, Longsheng; Shi, Yun

doi:10.1016/j.ygcen.2005.07.009

Cited by 195 publications

(121 citation statements)

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“…A compound is called active when its binding to TR stabilizes a conformational change of the receptor, that leads to the recruitment of coactivators (like SRC1) that are required for the subsequent transcription of target genes (Flamant et al, 2006). Note that in some cases, the binding of the hormone induces gene repression probably via corepressor recruitment (Guissouma et al, 2005).This review does not intend to be exhaustive about TH signaling in mammals or in amphibians, so for further information see (Yen, 2001;Zhang and Lazar, 2000) for general reviews on TH action and more specifically (Brown and Cai, 2007;Buchholz et al, 2006;Tata, 2006) about amphibians.…”

Section: Th and Th Derivative Synthesis In Tetrapodsmentioning

confidence: 99%

“…The two ''classical'' vertebrate TRs, TRa and TRb, that have diverged from the vertebratespecific genome duplication (Escriva et al, 2002) have been quite extensively studied in mammals and amphibians (Buchholz et al, 2006;Flamant et al, 2006). They were shown to preferentially bind T 3 and to be the main mediators of T 3 action.…”

Section: Tr Is the Th Receptor In Chordatesmentioning

confidence: 99%

“…Some T 3 is also produced in the thyroid (thus both T 3 and T 4 will be referred as THs). Indeed, exogenous T 3 or T 4 prematurely induces metamorphosis (Gudernatsch, 1912), whereas inhibition of endogenous T 3 or T 4 synthesis blocks metamorphosis and produces giant tadpoles (Allen, 1916;Buchholz et al, 2006). More precisely, there is a peak of TH production at the beginning of metamorphosis, which is the key physiological trigger [ (Leloup and Buscaglia, 1977) for review, see (Tata, 2006)].…”

mentioning

confidence: 99%

“…In the absence of ligand, the receptor is located on specific response elements in the regulatory regions of target genes and actively inhibits transcription. Ligand binding activates the receptor which then modulates the transcription of target genes, subsequently causing the morphological remodeling characteristic of metamorphosis (Buchholz et al, 2006). There are two TRs in anurans (TRa and TRb) from a vertebrate-specific genome duplication (Dehal and Boore, 2005;Escriva et al, 2002) [actually there are two TRa and two TRb in Xenopus laevis from a recent speciesspecific genome duplication (Escriva et al, 2002), but the duplicates are functionally redundant].…”

mentioning

confidence: 99%

“…TRa and TRb have specific roles in the process of amphibian metamorphosis: TRb is mainly implicated as a molecular switch triggered by the rise of TH levels, whereas TRa is instrumental in blocking the metamorphosis program before TH levels increase (Brown and Cai, 2007;Havis et al, 2006). More precisely, TRa is expressed very early, even before TH synthesis, whereas TRb expression is controlled by and thus correlates with TH levels [ (Kawahara et al, 1991), review in (Buchholz et al, 2006)]. This peak of TRb expression at the onset of metamorphosis is particularly important, because it transmits the signal of the peak of TH: as TRb is one of its own target genes, the peak of TH production activates a positive loop of TRb production and activation characteristic of the metamorphosis climax (Tata et al, 1993).…”

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confidence: 99%

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The history of a developmental stage: Metamorphosis in chordates

Paris

Laudet

2008

Genesis

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Summary: Metamorphosis displays a striking diversity in chordates, a deuterostome phylum that comprises vertebrates, urochordates (tunicates), and cephalochordates (amphioxus). In anuran amphibians, the tadpole loses its tail, develops limbs, and undergoes profound changes at the behavioral, physiological, biochemical, and ecological levels. In ascidian tunicates, the tail is lost and the head tissues are drastically remodeled into the adult animal, whereas in amphioxus, the highly asymmetric larva transforms into a relatively symmetric adult. This wide diversity has led to the proposal that metamorphosis evolved several times independently in the different chordate lineages during evolution. However, the molecular mechanisms involved in metamorphosis are largely unknown outside amphibians and teleost fishes, in which metamorphosis is regulated by the thyroid hormones (TH) T 3 and T 4 binding to their receptors (thyroid hormone receptors). In this review, we compare metamorphosis in chordates and then propose a unifying definition of the larva-to-adult transition, based on the conservation of the role of THs and some of their derivatives as the main regulators of metamorphosis. According to this definition, all chordates (if not, all deuterostomes) have a homologous metamorphosis stage during their postembryonic development. The intensity and the nature of the morphological remodeling varies extensively among taxa, from drastic remodeling like in some ascidians or amphibians to more subtle events, as in mammals. genesis 46:657-672,

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Section: Th and Th Derivative Synthesis In Tetrapodsmentioning

confidence: 99%

Section: Tr Is the Th Receptor In Chordatesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The history of a developmental stage: Metamorphosis in chordates

Paris

Laudet

2008

Genesis

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Regulation of Adult Intestinal Stem Cells through Thyroid Hormone‐Induced Tissue Interactions during Amphibian Metamorphosis

Ishizuya‐Oka

2014

Cell and Molecular Biology and Imaging of Stem Cells

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Tissue‐dependent induction of apoptosis by matrix metalloproteinase stromelysin‐3 during amphibian metamorphosis

Mathew

Hasebe

et al. 2010

Birth Defects Research Pt C

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Matrix metalloproteinases (MMPs) are a superfamily of Zn2+-dependent proteases that are capable of cleaving the proteinaceous component of the extracellular matrix (ECM). The ECM is a critical medium for cell-cell interactions and can also directly signal cells through cell surface ECM receptors, such as integrins. In addition, many growth factors and signaling molecules are stored in the ECM. Thus, ECM remodeling and/or degradation by MMPs are expected to affect cell fate and behavior during many developmental and pathological processes. Numerous studies have shown that the expression of MMP mRNAs and proteins associates tightly with diverse developmental and pathological processes such as tumor metastasis and mammary gland In vivo involution. evidence to support the roles of MMPs in these processes has been much harder to get. Here we will review some of our studies on the MMP11 or stromelysin-3 during the thyroid hormone-dependent amphibian metamorphosis, a process that resembles the so-called postembryonic development in mammals (from a few months before to several months after birth in humans when organ growth and maturation take place). Our investigations demonstrate that stromelysin-3 controls apoptosis in different tissues via at least two distinct mechanisms.

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Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog

Cited by 195 publications

References 167 publications

The history of a developmental stage: Metamorphosis in chordates

The history of a developmental stage: Metamorphosis in chordates

Regulation of Adult Intestinal Stem Cells through Thyroid Hormone‐Induced Tissue Interactions during Amphibian Metamorphosis

Tissue‐dependent induction of apoptosis by matrix metalloproteinase stromelysin‐3 during amphibian metamorphosis

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