Molecular and Genetic Aspects of Odontogenic Lesions

Bilodeau, Elizabeth A.; Prasad, Joanne L.; Alawi, Faizan; Seethala, Raja R.

doi:10.1007/s12105-014-0588-7

Cited by 17 publications

(16 citation statements)

References 70 publications

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“…This lesion is an uncommon neoplasm of the maxillary bones and represents between 2.3 and 3.4% of all odontogenic tumors ( 11 - 13 ), which could be evidenced in the present study with only 23 cases out of a total of 16,000 cases diagnosed in the maxillary bone over 40 years. The average age of the patients was 20.38 years and agreed with the information available in other studies, which indicate that the age group most affected by OM is in the second and third decade of life ( 5 , 13 ).…”

Section: Discussionsupporting

confidence: 49%

Odontogenic Myxoma: Follow-Up of 13 cases after conservative surgical treatment and review of the literature

et al. 2021

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Background We aim to report a serie of odontogenic myxoma over a 40-year period. Material and Methods We conducted a retrospective and sectional review of OM cases. The clinical, radiographic and treatment data were collected from clinical records included cases whose medical records contained clinical, radiographic, histopathological, follow-up data of at least six months. Results There was a mild preference for the male with a mean age of 22.8 years. Seventy-seven percent of the lesions occurred in the posterior region of the mandible, presenting a multilocular radiolucent aspect (54%) with one presenting symptomatology. Conservative treatment was performed in all patients initially and recurrence was observed in two cases. Conclusions Odontogenic myxoma has a well-defined clinical profile and the choice of treatment should consider aspects such as patient’s age, lesion size, and location. Key words: Myxoma, odontogenic tumors, diagnosis, treatment.

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Section: Discussionsupporting

confidence: 49%

Odontogenic Myxoma: Follow-Up of 13 cases after conservative surgical treatment and review of the literature

et al. 2021

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“…Differential diagnosis of CCOC includes benign odontogenic tumors, such as ameloblastoma and the clear cell variant of calcifying epithelial odontogenic tumor; metastatic tumors, as renal clear cell carcinoma and melanoma; tumors of salivary origin, as mucoepidermoid carcinoma and, especially, hyalinizing clear cell carcinoma (HCCC) [5,11]. Immunohistochemistry is a valuable aid to differentiate some of those lesions (i.e.…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Odontogenic Carcinoma Harboring the EWSR1–ATF1 Fusion Gene: Report of a Rare Case

Santana

Andrade

Melo

et al. 2019

Head and Neck Pathol

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Clear cell odontogenic carcinoma (CCOC) is a rare and aggressive malignant epithelial neoplasm, which occurs most frequently in the mandible of elderly patients. Morphologically, CCOC shares similar characteristics with other clear cell tumors, especially hyalinizing clear cell carcinoma of the salivary glands (HCCC). Both CCOC and HCCC are known to harbor EWSR1 rearrangements, especially the EWSR1-ATF1 gene fusion, which indicates a possible link between the two lesions. So far, this fusion has been demonstrated in five cases of CCOC in the literature. Herein, we add another CCOC case to the literature, which arose in the mandible of an 82-year-old female patient and was proven to harbor the EWSR1-ATF1 gene fusion. Immunohistochemically, this case was focally positive for CK7, CK14, CK19 and p63. The patient was referred to surgical treatment; however, she died of disease 2 months after the diagnosis, thereby demonstrating the aggressive nature of this tumor.

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“…While DC poses excellent prognosis and rarely recurs, OKC demonstrates as high as 30 % recurrence rate following enucleation [ 21 ]. Within the group of epithelial odontogenic tumor, ameloblastoma (AM) is locally aggressive in nature, whereas adenomatoid odontogenic tumor (AOT) have limited growth potential with virtually no recurrence[ 22 ]. Calcifying odontogenic cyst (COC) is the cystic lesion showing ameloblastoma-like epithelium with low recurrence potential [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of SOX2 and OCT4 in odontogenic cysts and tumors

et al. 2021

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Background Aberrant expression of stem cell markers has been observed in several types of neoplasms. This trait attributes to the acquired stem-like property of tumor cells and can impact patient prognosis. The objective of this study was to comparatively analyze the expression and significance of SOX2 and OCT4 in various types of odontogenic cysts and tumors. Methods Fifty-five cases of odontogenic cysts and tumors, including 15 ameloblastomas (AM), 5 adenomatoid odontogenic tumors (AOT), 5 ameloblastic fibromas (AF), 5 calcifying odontogenic cysts (COC), 10 dentigerous cysts (DC) and 15 odontogenic keratocysts (OKC) were investigated for the expression of SOX2 and OCT4 immunohistochemically. Results Most OKCs (86.7 %) and all AFs expressed SOX2 in more than 50 % of epithelial cells. Its immunoreactivity was moderate-to-strong in all epithelial cell types in both lesions. In contrast, SOX2 expression was undetectable in AOTs and limited to the ameloblast-like cells in a minority of AM and COC cases. Most DCs showed positive staining in less than 25 % of cystic epithelium. Significantly greater SOX2 expression was noted in OKC compared with DC or AM, and in AF compared with COC or AOT. OCT4 rarely expressed in odontogenic lesions with the immunoreactivity being mild and present exclusively in OKCs. Conclusions SOX2 is differentially expressed in odontogenic cysts and tumors. This could be related to their diverse cells of origin or stages of histogenesis. The overexpression of SOX2 and OCT4 in OKC indicates the acquired stem-like property. Future studies should investigate whether the overexpression of OCT4 and SOX2 contributes to the aggressive behaviors of the tumors.

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Molecular and Genetic Aspects of Odontogenic Lesions

Cited by 17 publications

References 70 publications

Odontogenic Myxoma: Follow-Up of 13 cases after conservative surgical treatment and review of the literature

Odontogenic Myxoma: Follow-Up of 13 cases after conservative surgical treatment and review of the literature

Clear Cell Odontogenic Carcinoma Harboring the EWSR1–ATF1 Fusion Gene: Report of a Rare Case

Expression of SOX2 and OCT4 in odontogenic cysts and tumors

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