Molecular and health effects in the upper respiratory tract associated with tobacco smoking other than cigarettes

Szyfter, Krzysztof; Napierała, Marek; Florek, Ewa; Braakhuis, Boudewijn J.M.; Takes, Robert P.; Rodrigo, Juan P.; Rinaldo, Alessandra; Silver, Carl E.; Ferlito, Alfio

doi:10.1002/ijc.31846

Cited by 16 publications

(15 citation statements)

References 105 publications

(237 reference statements)

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“…In agreement with the health risks identified to date, analytical examination of the components in WP smoke include a mixture of chemicals with known or suspected disease-causative agents that closely resemble those found in cigarette smoke (CS), and in many cases at higher concentrations 20 21. Indeed, WP is estimated to deliver to cells and tissues a similar group of toxicants that are known to dysregulate cell molecular mechanisms, including DNA repair and methylation 22–26. Herein, we investigated the effects of lung health using a murine model by analysing inflammation and pulmonary function after chronic WP exposure for 6 months.…”

Section: Introductionmentioning

confidence: 95%

Immune modulation by chronic exposure to waterpipe smoke and immediate-early gene regulation in murine lungs

et al. 2019

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ObjectiveWe investigated the effects of chronic waterpipe (WP) smoke on pulmonary function and immune response in a murine model using a research-grade WP and the effects of acute exposure on the regulation of immediate-early genes (IEGs).MethodsWP smoke was generated using three WP smoke puffing regimens based on the Beirut regimen. WP smoke samples generated under these puffing regimens were quantified for nicotine concentration. Mice were chronically exposed for 6 months followed by assessment of pulmonary function and airway inflammation. Transcriptomic analysis using RNAseq was conducted after acute exposure to characterise the IEG response. These biomarkers were then compared with those generated after exposure to dry smoke (without water added to the WP bowl).ResultsWe determined that nicotine composition in WP smoke ranged from 0.4 to 2.5 mg per puffing session. The lung immune response was sensitive to the incremental severity of chronic exposure, with modest decreases in airway inflammatory cells and chemokine levels compared with air-exposed controls. Pulmonary function was unmodified by chronic WP exposure. Acute WP exposure was found to activate the immune response and identified known and novel IEG as potential biomarkers of WP exposure.ConclusionChronic exposure to WP smoke leads to immune suppression without significant changes to pulmonary function. Transcriptomic analysis of the lung after acute exposure to WP smoke showed activation of the immune response and revealed IEGs that are common to WP and dry smoke, as well as pools of IEGs unique to each exposure, identifying potential biomarkers specific to WP exposure.

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Section: Introductionmentioning

confidence: 95%

Immune modulation by chronic exposure to waterpipe smoke and immediate-early gene regulation in murine lungs

et al. 2019

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“…One in vitro study concluded that water-soluble polymer-encapsulated nano-luteolin from hydrophobic luteolin (PLA-PEG) inhibited the growth of lung cancer cells (H292 cell line) and squamous cell carcinoma of head and neck (SCCHN) cells (Tu212 cell line) [ 86 ], which are among the most frequent cancers worldwide [ 87 , 88 , 89 ]. Moreover, in vivo study using a tumour xenograft mouse model demonstrated that nano-luteolin has a significant inhibitory effect on the tumour growth of SCCHN in comparison to free luteolin [ 86 ].…”

Section: Luteolinmentioning

confidence: 99%

Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy

2020

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Flavonoids, a ubiquitous group of naturally occurring polyphenolic compounds, have recently gained importance as anticancer agents. Unfortunately, due to low solubility, absorption, and rapid metabolism of dietary flavonoids, their anticancer potential is not sufficient. Nanocarriers can improve the bioavailability of flavonoids. In this review we aimed to evaluate studies on the anticancer activity of flavonoid nanoparticles. A review of English language articles published until 30 June 2020 was conducted, using PubMed (including MEDLINE), CINAHL Plus, Cochrane, and Web of Science data. Most studies determining the anticancer properties of flavonoid nanoparticles are preclinical. The potential anticancer activity focuses mainly on MCF-7 breast cancer cells, A549 lung cancer cells, HepG2 liver cancer cells, and melanoma cells. The flavonoid nanoparticles can also support the anti-tumour effect of drugs used in cancer therapy by enhancing the anti-tumour effect or reducing the systemic toxicity of drugs.

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“…The high prevalence of tobacco consumption and its detrimental effects on human health make it difficult to curb the associated mortality. Tobacco use increases the risk of cardiovascular disease [ 8 , 9 ], respiratory disease [ 10 , 11 , 12 ], and cancer [ 13 , 14 , 15 , 16 ]. Indeed, tobacco is the largest preventable cause of cancer [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence

Saravia

Ten-Blanco

Pereda-Pérez

et al. 2021

IJMS

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Nicotine, the main psychoactive component in tobacco smoke, plays a major role in tobacco addiction, producing a high morbidity and mortality in the world. A great amount of research has been developed to elucidate the neural pathways and neurotransmitter systems involved in such a complex addictive behavior. The endocannabinoid system, which has been reported to participate in the addictive properties of most of the prototypical drugs of abuse, is also implicated in nicotine dependence. This review summarizes and updates the main behavioral and biochemical data involving the endocannabinoid system in the rewarding properties of nicotine as well as in nicotine withdrawal and relapse to nicotine-seeking behavior. Promising results from preclinical studies suggest that manipulation of the endocannabinoid system could be a potential therapeutic strategy for treating nicotine addiction.

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Molecular and health effects in the upper respiratory tract associated with tobacco smoking other than cigarettes

Cited by 16 publications

References 105 publications

Immune modulation by chronic exposure to waterpipe smoke and immediate-early gene regulation in murine lungs

Immune modulation by chronic exposure to waterpipe smoke and immediate-early gene regulation in murine lungs

Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy

New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence

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