Molecular and immunological changes in blood of rats exposed to various doses of asbestos dust

Ainagulova, Galiya; Bulgakova, Olga; Ilderbayev, Oralbek; Manekenova, Kenzhekyz; Tatayeva, Roza; Bersimbaev, R. I.

doi:10.1016/j.cyto.2022.156016

Cytokine

2022

DOI: 10.1016/j.cyto.2022.156016

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Molecular and immunological changes in blood of rats exposed to various doses of asbestos dust

Galiya Ainagulova

Olga Bulgakova

Oralbek Ilderbayev

et al.

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2024

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Cited by 4 publications

References 43 publications

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Evaluation of morphological parameters, PLR and NLR inflammation indicators in patients with long-term COVID-19 of mild and severe complexity

Stróż,

Kosiorek,

Zbroch

et al. 2024

Pol. Ann. Med.

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IntroductionCOVID-19 can have long-lasting effects, but the effects on blood parameters and inflammation are poorly understood. The aim of this study was to evaluate morphological and inflammatory markers in long-term COVID-19 patients.AimTo evaluate complete blood count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and morphology in mild versus severe long COVID-19.Material and methodsIn total, 39 long COVID-19 patients were stratified into mild (<i>n</i> = 25) and severe (<i>n</i> = 14) groups. Blood counts, NLR, PLR were measured. Cell morphology was analysed. ROC curves were used to determine biomarker thresholds. Survival was assessed using Kaplan–Meier curves.Results and discussionSevere patients had lower leukocytes but higher neutrophils, indicating greater inflammation. NLR and PLR were significantly increased in severe patients compared to mild patients (NLR 12 vs 8; PLR 140 vs 100). NLR and PLR were higher than in controls, confirming their utility as inflammatory markers. NLR and PLR effectively discriminated between mild and severe disease. High NLR and PLR predicted poorer prognosis. Altered leukocyte morphology such as cytoplasmic vacuolization correlated with severity.ConclusionsNLR and PLR are promising biomarkers for assessing severity of long COVID-19, while morphological changes in blood cells provide additional evidence of inflammation. Further studies in larger populations are warranted.

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Evaluation of morphological parameters, PLR and NLR inflammation indicators in patients with long-term COVID-19 of mild and severe complexity

Stróż,

Kosiorek,

Zbroch

et al. 2024

Pol. Ann. Med.

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Asbest İçeren Çimento Esaslı Çatı Kaplama Levhalarının Sökümü İşlerinde Risk Değerlendirme

ŞAHİN

BİNGÖL

2022

Karaelmas İş Sağlığı Ve Güvenliği Dergisi

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Bu çalışmada, eski yapılara sahip fabrikalarda çatı kaplama malzemesi olarak kullanılan çimento esaslı oluklu levhaların örnek olarak seçilmiş bir fabrikada ‘’Malzeme Değerlendirme Algoritması’’ ve “Asbest Risk Değerlendirme” yöntemleri kullanılarak risk seviyesi belirlenmiştir. Uygulama için seçilen fabrikadaki çatı kaplama malzemeleri incelenerek ürün tipi, hasar durumu, yüzey durumu ve asbestin tipi unsurları puanlanarak lif yayma potansiyeli tespit edilmiştir. Aynı malzemeler için asbestli malzemenin bulunduğu alanda gerçekleştirilen faaliyetin tipi, asbestli kaplamaların yeri, bu levhalara ulaşılabilirlik durumu, miktarı, alandaki kullanıcı sayısı, kullanım sıklığı, bakım tipi ve bakım periyodu değerlendirilerek toplam risk skoru belirlenmiştir. Yapılan analiz ile malzeme değerlendirme algoritmasından elde edilen puan (6 puan) ile asbest risk değerlendirmesinden elde edilen puan (11) toplanarak 17 puan orta risk skoru elde edilmiştir. Bu sonuca göre orta vadede aksiyon alınması gerektiği sonucuna varılmıştır. Söküm sırasında karşılaşılabilecek diğer tehlikeler ise iş tehlike analizi ile tespit edilmiştir. Bu çalışma ile asbest içerikli levhalardaki liflerin sebep olabileceği hastalıklar ve olası tehlikeler, bu malzemelerin uzaklaştırılmasında uyulacak kurallar ve korunma tedbirlerinin artırılması hakkında farkındalığın yükseltilmesi amaçlanmıştır. Ayrıca asbest hakkındaki Türkiye’deki mevzuat ile asbesti yasaklamış ülkelerin mevzuatları karşılaştırılarak Türkiye’deki mevzuata eklenmesi gereken konular hakkında bir analiz yapılmıştır.

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Coronavirus infection and systemic inflammatory reaction syndrome

Sarsembayev,

Madyarov,

Kuzikeev

et al. 2024

Polski Merkuriusz Lekarski

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Aim: The purpose of this study was a clinical approbation of the Kometad drug (international non-proprietary name sodium colistimethate), an antibiotic from the polymyxin group in patients with severe course of confirmed сoronavirus infection in the intensive care unit of the Branch of the I. Zhekenova Municipal Clinical Infectious Diseases Hospital. Materials and Methods: The methodology is based on both theoretical and empirical methods of scientific cognition. During the study, the features of the Coronavirus infection and the inflammatory reaction syndrome were considered, which became quite a big problem during the pandemic. Results: The main indications for the tested drug and the consequences of its use for one age group were also determined. Conclusions: The conclusion was made about the positive dynamics of the patients’ health status, and recommendations were given for further research in this area. The practical significance of this study lies in the first clinical approbation of the Kometad drug, which can be used in medicine to reduce the severity of the systemic inflammatory reaction syndrome and improve the patient’s health as a result of the disease of Coronavirus infection, after further clinical trials of the drug with different age groups of patients.

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Molecular and immunological changes in blood of rats exposed to various doses of asbestos dust

Cited by 4 publications

References 43 publications

Evaluation of morphological parameters, PLR and NLR inflammation indicators in patients with long-term COVID-19 of mild and severe complexity

Evaluation of morphological parameters, PLR and NLR inflammation indicators in patients with long-term COVID-19 of mild and severe complexity

Asbest İçeren Çimento Esaslı Çatı Kaplama Levhalarının Sökümü İşlerinde Risk Değerlendirme

Coronavirus infection and systemic inflammatory reaction syndrome

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