Molecular and neural mechanisms regulating sexual motivation of virgin female Drosophila

Ishimoto, Hiroshi; Kamikouchi, Azusa

doi:10.1007/s00018-021-03820-y

Cited by 13 publications

(6 citation statements)

References 152 publications

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“…The trans -Tango analysis identified a subset of neurons with cell bodies in the suboesophageal ganglion with projections to the pars intercerebralis for SPR8 ∩ dsx and fru11/12 ∩ dsx neurons (Figures 7K and 7L). For SPR8 ∩ fru11/12 and SPR8 ∩ FD6 neurons common target neurons were found in the antennal mechanosensory and motor centre (AMMC) region with a single neuron identified near the mushroom body region (Figures 7M and 7N) (Ishimoto and Kamikouchi, 2021) . For fru11/12 ∩ FD6 no obvious targets were identified in the central brain (Figure 7O).…”

Section: Resultsmentioning

confidence: 99%

Sex-peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response

Nallasivan,

Singh,

Saleh

et al. 2024

Preprint

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Sex-peptide (SP) transferred during mating induces female post-mating responses including refractoriness to re-mate and increased oviposition in Drosophila. Yet, where SP target neurons reside, remained uncertain. Here we show that expression of membrane-tethered SP (mSP) in the head or trunk either reduces receptivity or increases oviposition, respectively. Using fragments from large regulatory regions of Sex Peptide Receptor, fruitless and doublesex genes together with intersectional expression of mSP, we identified distinct interneurons in the brain and abdominal ganglion controlling receptivity and oviposition. These interneurons can induce post-mating responses through SP received by mating. Trans-synaptic mapping of neuronal connections reveals input from sensory processing neurons and two post-synaptic trajectories as output. Hence, SP target neurons operate as key integrators of sensory information for decision of behavioural outputs. Multi-modularity of SP targets further allows females to adjust SP-mediated male manipulation to physiological state and environmental conditions for maximizing reproductive success.

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Section: Resultsmentioning

confidence: 99%

Sex-peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response

Nallasivan,

Singh,

Saleh

et al. 2024

Preprint

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“…Therefore, SP may act as a peptide hormone to activate SPR in the CNS. Transmission of SP/SPR signalling from the reproductive tract to the brain leads to multiple post-mating responses, including increased food intake, reproductive maturation, and decreased sexual receptivity through downstream neuronal circuits [ 220 , 221 ] ( Figure 4a ). SPR can also be activated by MIP/AstB, another ligand for SPR [ 222 , 223 ].…”

Section: Peripherally Derived Peptide Hormones: Post-mating Responses...mentioning

confidence: 99%

Interorgan communication through peripherally derived peptide hormones inDrosophila

Okamoto

Watanabe

2022

Fly

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In multicellular organisms, endocrine factors such as hormones and cytokines regulate development and homoeostasis through communication between different organs. For understanding such interorgan communications through endocrine factors, the fruit fly Drosophila melanogaster serves as an excellent model system due to conservation of essential endocrine systems between flies and mammals and availability of powerful genetic tools. In Drosophila and other insects, functions of neuropeptides or peptide hormones from the central nervous system have been extensively studied. However, a series of recent studies conducted in Drosophila revealed that peptide hormones derived from peripheral tissues also play critical roles in regulating multiple biological processes, including growth, metabolism, reproduction, and behaviour. Here, we summarise recent advances in understanding target organs/tissues and functions of peripherally derived peptide hormones in Drosophila and describe how these hormones contribute to various biological events through interorgan communications.

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“…Egg-laying involves different neuronal components (Figure 1) that overlap with other aspects of female reproductive behavior and motivation (Ishimoto & Kamikouchi, 2021). Ovipositor extension can be part of mating, rejection, and egg-laying behavior.…”

Section: Introductionmentioning

confidence: 99%

Neurobiology of Egg-laying Behavior in <em>Drosophila</em>:<em> </em>Neural Control of the Female Reproductive System

Afkhami¹

2023

Preprint

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Egg-laying is one of the key aspects of female reproductive behavior in insects. Egg-laying has been studied since the dawn of Drosophila melanogaster as a model organism. The female’s internal state, hormones, and external factors, including nutrition, light, and social environment, affect egg-laying output. However, only recently has light been shed on certain neurobiological features of egg-laying behavior in both the central and peripheral nervous systems. The central nervous system regulates egg-laying behavior and decision-making, and many studies use fruitless and doublesex, two genes in the sex determination pathway, to identify reproductively important neurons. Neuronal groups like aDNs and pC1clusters modulate egg-laying behavior in the brain, and other neurons like oviINs and oviDNs affect oviposition specifically. In the ventral nerve cord, the abdominal neuromere houses neurons that send information to and from the reproductive tract, including sex peptide abdominal ganglion neurons (SAG) and octopaminergic motor neurons. The reproductive tract itself houses sensory neurons that respond to different aspects of egg maturation and mating, including the male accessory gland products and mechanical stimuli. I conclude this review by summarizing the importance of egg-laying neuronal control in various evolutionary phenomena like cryptic female choice and highlight two Drosophila species and provide intriguing avenues for the future of the field.

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Molecular and neural mechanisms regulating sexual motivation of virgin female Drosophila

Cited by 13 publications

References 152 publications

Sex-peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response

Sex-peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response

Interorgan communication through peripherally derived peptide hormones inDrosophila

Neurobiology of Egg-laying Behavior in <em>Drosophila</em>:<em> </em>Neural Control of the Female Reproductive System

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