Molecular and serological markers of human parvovirus B19 infection in blood donors

Abstract

BACKGROUND: Human parvovirus B19 (B19V) is one of the blood-borne viruses. The virus can be transmitted to susceptible individuals by blood or blood products. The virus is not associated with significant disease in general population, while people with underlying problems such as immunodeficiency can cause anemia and arthritis. The current systematic review and meta-analysis aimed to estimate the overall prevalence of B19V DNA, anti-B19V IgG, and anti-B19V IgM antibodies in blood donors worldwide. METHODS: A systematic search was carried out in online databases for relevant studies from inception until March 30, 2019. Study selection was performed based on predesigned eligibility criteria. The proportion of B19V DNA, anti-B19V IgG, and anti-B19V IgM antibodies were pooled using the inverse variance method. All statistical analyses were performed using the R version 3.5.3, package “meta.” RESULTS: According to the random-effects model, the pool prevalence of B19V DNA, anti-B19V IgM, and anti-B19V IgG among blood donors was calculated to be 0.4% (95% confidence interval [CI] =0.3%–0.6%), 2.2% (95% CI = 1.3%–3.7%), and 50.1% (95% CI = 43.1%–57.1%), respectively. CONCLUSION: For the transmission of B19V through blood, the presence of the virus genome is required, and the present study showed that the prevalence of the virus genome in blood donors is <1%. Therefore, there is no need to screen donated blood for B19V infection.

Seroprevalence of human immunodeficiency virus in African blood donors: a systematic review and meta-analysis

“…The remaining 122 studies were considered for qualitative and quantitative synthesis, involving 7,814,996 participants. Among those 180 studies that did not meet our inclusion criteria, 73 did not study the prevalence of HIV among blood donors; 43 were systematic reviews 8 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ; 18 studies did not have relevant data 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ; five studies did not have their full text available 32 , 48 , 67 , 68 , 69 , 70 , 71 ; 11 studies included population already positive for HIV 67 , 71 , 72 , 73 , 74 , 75 ; nine studies included children 53 , 54 ,…”

Parvovirus B19 infection: characteristics of population immunity in the world

“…It was isolated from infants and children suffering from acute respiratory diseases of the upper and lower respiratory tract by molecular viral screening based on cloning and bioinformatics analysis [16,17]. This pathogen is the fourth most common virus detected in respiratory samples after adenoviruses, rhinoviruses, and respiratory syncytial virus (it is the cause of acute respiratory viral diseases in children and adolescents in 9-20% of cases) [18][19][20].…”