Molecular aspects of preeclampsia

Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics

“…63 Systematic changes in gene, protein or metabolite expression may predict or explain disease. Metabolomics is de ned as the quantitative measurement of the multiparametric metabolic response to pathophysiological stimuli or genetic modi cation .…”

New therapeutic approaches to treating hypertension in pregnancy

“…In addition, transforming growth factor beta (TGF-b) receptors can also enhance eNOS expression and/or activation, including in endothelial cells from human fetoplacental circulation. This action is enhanced by the coactivator protein endoglin [16] (Fig. 1).…”

“…In preeclampsia, however, excessive oxidative stress initiates an inflammatory response within the vasculature, with typical features of endothelial dysfunction [16]. The interplay between oxidative stress and inflammation would then be involved in the initiation and progression of hypertension in preeclamptic patients, as occurs in the regular arterial hypertension process [18].…”

Circulating levels of homocysteine in preeclamptic women

“…Preeclampsia is characterized by the onset of hypertension and proteinuria after 20 weeks of gestation in a previously normotensive pregnant woman 1,3 . Despite a fairly high incidence, the underlying etiology of preeclampsia is still incomplete 1,2 .…”

“…Despite a fairly high incidence, the underlying etiology of preeclampsia is still incomplete 1,2 . There are many theories about the etiology and pathogenesis of preeclampsia including endothelial dysfunction, inflammation and angiogenesis 1,3 .…”