Molecular Basis of Effector Recognition by Plant NB‐LRR Proteins

Ma, Lisong; Burg, Harrold A. van den; Cornelissen, Ben J. C.; Takken, Frank L. W.

doi:10.1002/9781118481431.ch2

Cited by 3 publications

(2 citation statements)

References 117 publications

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“…Over thousands of years, plants and pathogens have co‐evolved antagonistically. This co‐evolutionary battle enables plants to develop multilayered defence mechanisms and allows the pathogen to subvert host defences with a corresponding arsenal of counterstrategies (Bent & Mackey, 2007 , Ma et al, 2012a ). Plant pathogens have evolved virulence factors that interact with host proteins to interfere with host physiological processes and accelerate their infections (Regenmortel & Mahy, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Nicotiana benthamiana asparagine synthetase associates with IP‐L and confers resistance against tobacco mosaic virus via the asparagine‐induced salicylic acid signalling pathway

Liu

Tian

et al. 2021

Molecular Plant Pathology

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Section: Introductionmentioning

confidence: 99%

Nicotiana benthamiana asparagine synthetase associates with IP‐L and confers resistance against tobacco mosaic virus via the asparagine‐induced salicylic acid signalling pathway

Liu

Tian

et al. 2021

Molecular Plant Pathology

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“…The malfunctioning of LRR proteins can result in cancer, schizophrenia, eye and lung diseases. [23] Although these proteins are involved in influencing myriad of physiological processes from viruses [12] to animals [24] and plants [25] and even as potential photoswitchable protein in cell signaling [26] but information regarding their structure and function is not completely understood. These scaffold proteins are sticky in nature and tends to form homo-dimers or higher order oligomers which limits their structural characterization using Xray crystallography techniques.…”

Section: Introductionmentioning

confidence: 99%

Structural Advancement in Shoc2‐MAPK Signaling Pathways in the Treatment of Cancer and Other Diseases

Chawla

Chopra

2022

ChemistrySelect

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The structural advancement in Shoc, a prototypical Leucine rich protein, involved in MAPK pathway has added a new dimension in the development of drugs and therapeutics in treatment of cancer and other diseases. Here we have used computational studies to show that Shoc2 protein likely exhibits a dimer or even higher order oligomer structure during its scaffolding activity. The new perspective needs to be further explored for development of effective treatment against cancer, and other diseases.

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Molecular insights into Solanum sisymbriifolium’s resistance against Globodera pallida via RNA-seq

Varandas,

Barroso,

Conceição

et al. 2024

BMC Plant Biol

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Background The presence of potato cyst nematodes (PCN) causes a significant risk to potato crops globally, leading to reduced yields and economic losses. While the plant Solanum sisymbriifolium is known for its resistance to PCN and can be used as a trap crop, the molecular mechanisms behind this resistance remain poorly understood. In this study, genes differentially expressed were identified in control and infected plants during the early stages of the S. sisymbriifolium - G. pallida interaction. Results Gene expression profiles were characterized for two S. sisymbriifolium cultivars, Melody and Sis6001, uninfected and infected by G. pallida . The comparative transcriptome analysis revealed a total of 4,087 and 2,043 differentially expressed genes (DEGs) in response to nematode infection in the cultivars Melody and Sis6001, respectively. Gene ontology (GO) enrichment analysis provided insights into the response of the plant to nematode infection, indicating an activation of the plant metabolism, oxidative stress leading to defence mechanism activation, and modification of the plant cell wall. Genes associated with the jasmonic and salicylic acid pathways were also found to be differentially expressed, suggesting their involvement in the plant’s defence response. In addition, the analysis of NBS-LRR domain-containing transcripts that play an important role in hypersensitive response and programmed cell death led to the identification of ten transcripts that had no annotations from the databases, with emphasis on TRINITY_DN52667_C1_G1, found to be upregulated in both cultivars. Conclusions These findings represent an important step towards understanding the molecular basis underlying plant resistance to nematodes and facilitating the development of more effective control strategies against PCN. Supplementary Information The online version contains supplementary material available at 10.1186/s12870-024-05694-1.

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Molecular Basis of Effector Recognition by Plant NB‐LRR Proteins

Cited by 3 publications

References 117 publications

Nicotiana benthamiana asparagine synthetase associates with IP‐L and confers resistance against tobacco mosaic virus via the asparagine‐induced salicylic acid signalling pathway

Nicotiana benthamiana asparagine synthetase associates with IP‐L and confers resistance against tobacco mosaic virus via the asparagine‐induced salicylic acid signalling pathway

Structural Advancement in Shoc2‐MAPK Signaling Pathways in the Treatment of Cancer and Other Diseases

Molecular insights into Solanum sisymbriifolium’s resistance against Globodera pallida via RNA-seq

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