Molecular Biology of the Virus

Ross, L. J. N.

doi:10.1007/978-1-4613-2613-7_5

Cited by 21 publications

(14 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The BamHI-H fragment of MDV, which contains about 3 kbp of IRL, has been completely sequenced and no homology was detected to any other herpesvirus sequences, including the corresponding region of HSV (M. M. Binns, Ross, unpublished data). Also, the MDV and HVT genomes, at 166 kbp and 155 kbp respectively (Ross, 1985), are larger than that of VZV, at 125 kbp (Davison & Scott, 1986a), implying that they may contain additional coding regions.…”

Section: Mapping Identified Sequencesmentioning

confidence: 99%

Gene Sequence and Mapping Data from Marek's Disease Virus and Herpesvirus of Turkeys: Implications for Herpesvirus Classification

Buckmaster¹,

Scott²,

Sanderson³

et al. 1988

Journal of General Virology

165

View full text Add to dashboard Cite

SUMMARYPurified DNAs from Marek's disease virus (MDV) and the herpesvirus of turkeys (HVT) were randomly sheared and cloned into the M 13 bacteriophage. Two-hundred and ten MDV and 130 HVT clones were sequenced to give representative samples of the genome sequences. The predicted amino acid sequences from these gammaherpesviruses were compared to known sequences from other herpesviruses using computer analysis. Thirty-five MDV and 24 HVT genes were identified by comparison with varicella-zoster virus (VZV), an alphaherpesvirus. However, only 14 MDV and seven HVT genes, giving generally lower homology scores, were found by comparison with Epstein-Barr virus (EBV), a gammaherpesvirus, indicating that MDV and HVT sequences bear greater similarity to VZV than to EBV sequences. A number of sequences were mapped by hybridizing labelled M13 clones to Southern blots of restriction fragments of MDV or HVT DNA. The results were consistent with the MDV and HVT genomes being collinear with VZV.

show abstract

Section: Mapping Identified Sequencesmentioning

confidence: 99%

Gene Sequence and Mapping Data from Marek's Disease Virus and Herpesvirus of Turkeys: Implications for Herpesvirus Classification

Buckmaster¹,

Scott²,

Sanderson³

et al. 1988

Journal of General Virology

165

View full text Add to dashboard Cite

show abstract

“…Both MDV and HVT exhibit the 'wild-type' residues at all these above four positions. Additionally both MDV (strain HPRSI6) (Ross, 1985) and HVT (strain Fc-126) (N. Ross, unpublished data) appear to be sensitive to acyclovir. Despite cysteine residues frequently being important in determining the structural configuration of proteins by forming disulphide bonds, there is only one such residue conserved widely throughout the herpesvirus TKs studied.…”

Section: U~ C~mentioning

confidence: 99%

Nucleotide and Predicted Amino Acid Sequences of the Marek's Disease Virus and Turkey Herpesvirus Thymidine Kinase Genes; Comparison with Thymidine Kinase Genes of Other Herpesviruses

Scott¹,

Ross²,

Binns³

1989

Journal of General Virology

View full text Add to dashboard Cite

SUMMARYIn this paper we present the nucleotide sequences of the thymidine kinase (TK) genes of two avian herpesviruses : a highly oncogenic strain of Marek's disease virus (MDV strain RBIB) and its serologically related vaccine virus, the herpesvirus of turkeys (HVT strain Fc-126). The predicted coding regions of the two genes are 1029 and 1050 nucleotides respectively, corresponding to polypeptides of 343 and 350 amino acids in length. Putative nucleotide-and nucleoside-binding sites have been identified within the two predicted amino acid sequences. The MDV and HVT TK amino acid sequences exhibit 58-2~ amino acid identity. Comparison with other available herpesvirus TK sequences reveals a greater homology to those of the alphaherpesviruses than to those of the gammaherpesviruses. No overall homology was found when compared with the chicken cytoplasmic TK sequence.

show abstract

“…Certainly, there are marked differences in levels of latent infection (i.e. virus load) when susceptible and resistant chickens are compared Lee et al, 1981;Baigent et al, 1996), although it is difficult to discriminate between latently infected and transformed cells; the latter would be expected to be found primarily in susceptible-strain chickens and also would carry more genome copies per cell than latently infected, but non-transformed cells (Ross, 1985;Hirai, 1988).…”

Section: Infectionmentioning

confidence: 99%

Lymphomagenesis in Marek's disease

Calnek

1998

Avian Pathology

View full text Add to dashboard Cite

Molecular Biology of the Virus

Cited by 21 publications

References 53 publications

Gene Sequence and Mapping Data from Marek's Disease Virus and Herpesvirus of Turkeys: Implications for Herpesvirus Classification

Gene Sequence and Mapping Data from Marek's Disease Virus and Herpesvirus of Turkeys: Implications for Herpesvirus Classification

Nucleotide and Predicted Amino Acid Sequences of the Marek's Disease Virus and Turkey Herpesvirus Thymidine Kinase Genes; Comparison with Thymidine Kinase Genes of Other Herpesviruses

Lymphomagenesis in Marek's disease

Contact Info

Product

Resources

About