Molecular Catch and Release: Controlled Delivery Using Optical Trapping with Light‐Responsive Liposomes

Leung, Sarah J.; Romanowski, Marek

doi:10.1002/adma.201202180

Cited by 27 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…136,[148][149][150] In one particularly interesting example, they functionalized the nanoheaters with complementary nucleic acid strands, which upon light excitation can undergo dehybridization of the complementary strand, i.e., the therapeutic drug siRNA, inducing gene silencing. 136 Other approaches have been employed in organic microparticles (layer-by-layer capsules, 151 liposomes, 152 polymer particles, 75 etc.) functionalized with plasmonic NPs, which upon illumination can undergo a phase transition, enabling the release of the caged drug inside the cells.…”

Section: Plasmonic Heatingmentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

View full text Add to dashboard Cite

Abstract. Continuous advances in the field of bionanotechnology, particularly in the areas of synthesis and functionalization of colloidal inorganic nanoparticles with novel physicochemical properties, allow the development of innovative and/or enhanced approaches for medical solutions. Many of the present and future applications of bionanotechnology rely on the ability of nanoparticles to efficiently interact with electromagnetic (EM) fields and subsequently to produce a response via scattering or absorption of the interacting field. The crosssections of nanoparticles are typically orders of magnitude larger than organic molecules, which provide the means for manipulating EM fields and, thereby, enable applications in therapy (e.g., photothermal therapy, hyperthermia, drug release, etc.), sensing (e.g., surface plasmon resonance, surface-enhanced Raman, energy transfer, etc.), and imaging (e.g., magnetic resonance, optoacoustic, photothermal, etc.). Herein, an overview of the most relevant parameters and promising applications of EM-active nanoparticles for applications in life science are discussed with a view toward tailoring the interaction of nanoparticles with EM fields. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

Section: Plasmonic Heatingmentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

View full text Add to dashboard Cite

show abstract

“…As a result, these materials have been used for drug delivery, as nanoreactors, articial muscles, and motors. [7][8][9][10][11][12] Most previously reported photoresponsive materials have relied on photochromic molecules. 1 These molecules undergo a reversible isomerization upon irradiation with specic wavelengths of light.…”

mentioning

confidence: 99%

Light switchable optical materials from azobenzene crosslinked poly(N-isopropylacrylamide)-based microgels

et al. 2014

View full text Add to dashboard Cite

4 0 -Di(acrylamido)-azobenzene was used as a crosslinker in poly(Nisopropylacrylamide)-based microgels. The microgels were subsequently used to fabricate microgel-based optical materials (etalons), which exhibited optical properties that were switchable upon exposure to UV irradiation. We also show that the extent of the response depended on the UV exposure time. These materials could find applications for controlled/triggered drug delivery, as well as in various optical applications.Stimuli-responsive polymers, or "smart materials", have attracted great attention in the natural sciences within the last few decades. 1-4 These macromolecules/materials undergo physical and/or chemical changes in response to small variations in their environment. This interesting behavior has revolutionized the way we think about drug delivery, and has led to many advances in various elds of material science, chemistry, engineering, and physics. 2,5,6 Of the various stimuli that can be used to excite these systems, light has attracted much interest due to its ability to locally excite materials from remote locations. 7,8 Additionally, light induced excitation of materials can easily be started/stopped by simply switching the excitation source on/off, while the magnitude of the response can be tuned by modulating the excitation source intensity, and/or wavelength. As a result, these materials have been used for drug delivery, as nanoreactors, articial muscles, and motors. [7][8][9][10][11][12] Most previously reported photoresponsive materials have relied on photochromic molecules. 1 These molecules undergo a reversible isomerization upon irradiation with specic wavelengths of light. This process is capable of not only altering the molecular structure of the materials, but is oen accompanied by a local polarity change as well as a color change in the photochromic units. Several photochromic molecules have been used in the design of light responsive polymers, including azobenzene, spiropyran, dithienylethene, diazonaphthoquinone, and stilbene; 13,14 the most widely used being azobenzene. Azobenzene-containing molecules are well known to undergo trans to cis photoisomerizations and vice versa, which depend on the irradiation wavelength. 15 It is also notable that the isomerization results in a strong polarity change in the photochromic unit. The polarity change is a direct consequence of the change in the dipole moment from 0 Debye for the trans-isomer to 3 Debye for the cis-isomer. 16 Therefore, the photoisomerization from trans to cis increases the hydrophilicity of materials. 17 Azobenzene-containing polymers have been actively investigated for applications in optical data storage, nonlinear optical devices, sensors and actuators, as well as materials suitable for photo-fabrication/ processing. 18 Additionally, it has been shown that the photoisomerization can lead to material deformations. 19-21 For example, azobenzene photoisomerization in elastomers can yield up to a 20% change in their critical dimension. 22 Microgels, which...

show abstract

“…The preparative process was confirmed independently by others who have investigated plasmon resonant liposomes in vitro and in vivo 23 . We tested this novel technology in several assays requiring delivery of simple molecular probes or ligands 24 , 25 . Encouraged by these results we hypothesize that the plasmon resonant liposomes can support controlled release of antineoplastic agents used in the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes

Knights-Mitchell

Romanowski

2018

Nanotheranostics

Self Cite

View full text Add to dashboard Cite

Precise control of drug release from nanoparticles can improve efficacy and reduce systemic toxicity associated with administration of certain medications. Here, we combined two phenomena, photothermal conversion in plasmon resonant gold coating and thermal sensitivity of liposome compositions, to achieve a drug delivery system that rapidly releases doxorubicin in response to external stimulus.Methods: Thermosensitive liposomes were loaded with doxorubicin and gold-coated to produce plasmon resonant drug delivery system. Plasmon resonance facilitates release of contents upon near-infrared laser illumination, thus providing spatial and temporal control of the process. This controlled delivery system was compared to thermosensitive liposomes without gold coating and to the FDA-approved Doxil that was gold-coated to create a plasmon resonant coating. Release of doxorubicin from the gold-coated thermosensitive liposomes was further confirmed by tests of cell viability.Results: Upon laser illumination at 760 nm and 88 mW/cm2 power density, permeability of plasmon resonant liposomes increased by three orders of magnitude, from 70×10-12 to 60,000x10-12 cm/s. In control experiments, mild hyperthermia (42°C) increased permeability of these thermosensitive liposomes to just 3,700×10-12 cm/s. Neither hyperthermia nor laser illumination elicit content release from Doxil or plasmon resonant Doxil obtained by gold coating. Laser-induced release of doxorubicin from plasmon resonant thermosensitive liposomes resulted in the loss of cell viability significantly greater than in any of the control groups.Conclusion: Combination of thermosensitive liposomes with plasmon resonant coating enables rapid, controlled release, not currently available in pharmaceutical formulations of anticancer drugs.

show abstract

Molecular Catch and Release: Controlled Delivery Using Optical Trapping with Light‐Responsive Liposomes

Cited by 27 publications

References 29 publications

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Light switchable optical materials from azobenzene crosslinked poly(N-isopropylacrylamide)-based microgels

Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes

Contact Info

Product

Resources

About