Molecular changes after shockwave therapy in osteoarthritic knee in rats

Wang, C.-J.; Sun, Yaqiong; Wu, Cheng-Ta; Weng, Li‐Chueh; Wang, F.-S.

doi:10.1007/s00193-013-0480-5

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…The Dvl-Axin interaction is essential for Wnt/β-catenin signal transduction, it is worthy of further research and investigation. Our previous study showed that ESWT accelerates tissue regeneration in an osteoarthritic knee model in association with the expression of Wnt5a and β-catenin [ 43 ]. In this study, we investigated whether ESWT promotes diabetic wound healing in association with GSK-3/β-catenin phosphorylation signaling.…”

Section: Discussionmentioning

confidence: 99%

The Acceleration of Diabetic Wound Healing by Low-Intensity Extracorporeal Shockwave Involves in the GSK-3β Pathway

et al. 2020

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Previous studies have demonstrated that extracorporeal shock wave therapy (ESWT) could accelerate diabetic wound healing and that the inhibition of glycogen synthase kinase-3β (GSK-3β) is involved in epithelial differentiation during wound healing. This study investigated whether the enhancement of diabetic wound healing by ESWT is associated with the GSK-3β-mediated Wnt/β-catenin signaling pathway. A dorsal skin wounding defect model using streptozotocin-induced diabetic rodents was established. Rats were divided into 4 groups: group 1, normal controls without diabetes; group 2, diabetic controls without treatment; group 3, diabetic rats receiving ESWT; and group 4, rats receiving 6-bromoindirubin-3′oxime (BIO), a GSK-3β inhibitor, to trigger Wnt/β-catenin signaling. Tissue samples were collected and analyzed by immunohistochemical (IHC) staining and quantitative RT-PCR. The ESWT and BIO-treated groups both exhibited significant promotion of wound healing compared to the healing in controls without treatment. RT-PCR analysis of Wnt-1, -3a, -4, -5a, and -10 and β-catenin expression showed significantly increased expression in the ESWT group. The IHC staining showed that Wnt-3a and -5a and β-catenin levels were significantly increased in the ESWT and BIO treatment groups compared to the control groups. ESWT enhancement of diabetic wound healing is associated with modulation of the GSK-3β-mediated Wnt/β-catenin signaling pathway.

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Section: Discussionmentioning

confidence: 99%

The Acceleration of Diabetic Wound Healing by Low-Intensity Extracorporeal Shockwave Involves in the GSK-3β Pathway

et al. 2020

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The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders

Moya

Ramón

Schaden³

et al. 2018

The Journal of Bone and Joint Surgery

120

101

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suggests that extracorporeal shockwave treatment (ESWT) is safe and effective for treating several musculoskeletal disorders. ä Two types of technical principles are usually included in ESWT: focused ESWT (F-ESWT) and radial pressure waves (RPW). These 2 technologies differ with respect to their generation devices, physical characteristics, and mechanism of action but share several indications. ä Strong evidence supports the use of ESWT in calcifying tendinopathy of the shoulder and plantar fasciitis. ä The best evidence for the use of ESWT was obtained with low to medium energy levels for tendon disorders as well as with a high energy level for tendon calcification and bone pathologies in a comprehensive rehabilitation framework.

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Molecular changes after shockwave therapy in osteoarthritic knee in rats

Cited by 2 publications

References 20 publications

The Acceleration of Diabetic Wound Healing by Low-Intensity Extracorporeal Shockwave Involves in the GSK-3β Pathway

The Acceleration of Diabetic Wound Healing by Low-Intensity Extracorporeal Shockwave Involves in the GSK-3β Pathway

The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders

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