2006
DOI: 10.1038/sj.emboj.7601138
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Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s

Abstract: Hsp70 molecular chaperones function in protein folding in a manner dependent on regulation by co-chaperones. Hsp40s increase the low intrinsic ATPase activity of Hsp70, and nucleotide exchange factors (NEFs) remove ADP after ATP hydrolysis, enabling a new Hsp70 interaction cycle with non-native protein substrate. Here, we show that members of the Hsp70-related Hsp110 family cooperate with Hsp70 in protein folding in the eukaryotic cytosol. Mammalian Hsp110 and the yeast homologues Sse1p/2p catalyze efficient n… Show more

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Cited by 322 publications
(371 citation statements)
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References 47 publications
(96 reference statements)
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“…Our results documenting cell integrity pathway phenotypes with SSE1 and STI1 mutants are completely consistent with these findings. In addition, with the recent assignment of Sse1 as an Hsp70 nucleotide exchange factor, we have been able to extend our investigation to show that Hsp70 NEF activity is required for both cell integrity signaling and morphogenesis (Dragovic et al 2006;Raviol et al 2006;Shaner et al 2006;Shaner and Morano 2007).…”
Section: Discussionsupporting
confidence: 51%
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“…Our results documenting cell integrity pathway phenotypes with SSE1 and STI1 mutants are completely consistent with these findings. In addition, with the recent assignment of Sse1 as an Hsp70 nucleotide exchange factor, we have been able to extend our investigation to show that Hsp70 NEF activity is required for both cell integrity signaling and morphogenesis (Dragovic et al 2006;Raviol et al 2006;Shaner et al 2006;Shaner and Morano 2007).…”
Section: Discussionsupporting
confidence: 51%
“…1c, growth of sse1Δ cells was strongly inhibited in the presence of both compounds when compared to wild type. Sse1 and its paralog Sse2 function as nucleotide exchange factors for the cytosolic families of Hsp70, Ssa, and Ssb (Dragovic et al 2006;Raviol et al 2006;Shaner et al 2006). Likewise, metazoan Hsp110 performs a similar role for its cognate Hsp70 (Dragovic et al 2006).…”
Section: Resultsmentioning
confidence: 99%
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“…These proteins act as regulatory factors for Hsp70 [98,99] and, importantly, they have also been implicated as potent extracellular signalling proteins [100,101].…”
Section: Hsp70 Familymentioning
confidence: 99%