Molecular characteristics, clinical significance, and cancer immune interactions of cuproptosis and ferroptosis-associated genes in colorectal cancer

Yang, Li; Wang, Ru-yao; Deng, Yao; Wu, Shaohua; Sun, Xinti; Hong, Ming

doi:10.3389/fonc.2022.975859

Cited by 19 publications

(15 citation statements)

References 27 publications

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“…In a study on the prognostic risk of LGG patients, cuproptosis-related genes were analyzed by cox regression together with necroptosis-related genes, and the five genes that contributed most to the model construction were selected to construct the prognostic signature, however, these 5 genes were all considered to be necroptosis related in previous studies [ 189 ]. In the study on CRC, investigators selected cuproptosis-related genes together with ferroptosis-related genes to construct a prognostic signature, however, the contribution of each gene to the model was not described [ 190 ].…”

Section: Introductionmentioning

confidence: 99%

Cuproptosis: mechanisms and links with cancers

et al. 2023

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Cuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of cell death. The last decade has witnessed a considerable increase in investigations of programmed cell death, and whether copper induced cell death was an independent form of cell death has long been argued until mechanism of cuproptosis has been revealed. After that, increasing number of researchers attempted to identify the relationship between cuproptosis and the process of cancer. Thus, in this review, we systematically detailed the systemic and cellular metabolic processes of copper and the copper-related tumor signaling pathways. Moreover, we not only focus on the discovery process of cuproptosis and its mechanism, but also outline the association between cuproptosis and cancers. Finally, we further highlight the possible therapeutic direction of employing copper ion ionophores with cuproptosis-inducing functions in combination with small molecule drugs for targeted therapy to treat specific cancers.

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Section: Introductionmentioning

confidence: 99%

Cuproptosis: mechanisms and links with cancers

et al. 2023

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“…This result suggested that ferroptosis and cuproptosis might involve the pathology of NAFLD. Interestingly, ferroptosis and cuproptosis are both associated with CRN (especially CRC) ( Li et al, 2022 ; Zhang et al, 2022 ). This finding urged us to pursue the potential significance of ferroptosis and cuproptosis in NAFLD-related CRN (here we use CRC as an example), respectively.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the correlation between non-alcoholic fatty liver disease and the risk of colorectal neoplasms

Liu

Zhang

et al. 2022

Front. Pharmacol.

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This study aims at assessing the potential association between non-alcoholic fatty liver disease (NAFLD) and colorectal neoplasms (CRN). PubMed, Cochrane Library, and Embase were searched for cohort studies. 14 cohort studies with a total population of 38,761,773 were included for meta-analysis after selection. The results showed that NAFLD is related to an increased risk of CRN (OR = 1.23; 95% CI: 1.14–1.32; I2 = 70.7%, p < 0.001). In the subgroup analysis, NAFLD were found to be the independent risk factor of colorectal adenoma (CRA) (OR = 1.29; 95% CI = 1.15–1.45; I2 = 66.4%) and colorectal cancer (CRC) (OR = 1.13; 95% CI = 1.12–1.15; I2 = 69.4%). There is no close correlation between smoking status of NAFLD patients and CRN. Interestingly, bioinformatics analysis revealed that there were overlap of dysregulated gene sets among NAFLD, CRC, and two recently identified regulated cell death types, ferroptosis and cuproptosis, respectively. Our meta- and bioinformatics analysis shows that NAFLD increases the risk of CRN. Ferroptosis and cuproptosis may be the critical links between NAFLD and CRN, respectively. These findings here support that NAFLD is necessary to be considered as an emerging risk factor for CRN.

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“…Iron-sulfur cluster proteins play a key role in cuproptosis and their homeostasis is involved in cuproptosis-dependent cancer therapy. Several recent studies have shown that cuproptosis-associated genes, including iron-sulfur clusters, are potential predictors of diagnostic, prognostic, and therapeutic response in some cancers and are associated with tumor microenvironment, immune response and immunotherapy [143][144][145][146][147].…”

Section: Iron-sulfur Clusters and Cuproptosismentioning

confidence: 99%

Iron-Sulfur Clusters: A Key Factor of Regulated Cell Death in Cancer

Zhang

Liu

et al. 2022

Oxidative Medicine and Cellular Longevity

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Iron-sulfur clusters are ancient cofactors that play crucial roles in myriad cellular functions. Recent studies have shown that iron-sulfur clusters are closely related to the mechanisms of multiple cell death modalities. In addition, numerous previous studies have demonstrated that iron-sulfur clusters play an important role in the development and treatment of cancer. This review first summarizes the close association of iron-sulfur clusters with cell death modalities such as ferroptosis, cuprotosis, PANoptosis, and apoptosis and their potential role in cancer activation and drug resistance. This review hopes to generate new cancer therapy ideas and overcome drug resistance by modulating iron-sulfur clusters.

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Molecular characteristics, clinical significance, and cancer immune interactions of cuproptosis and ferroptosis-associated genes in colorectal cancer

Cited by 19 publications

References 27 publications

Cuproptosis: mechanisms and links with cancers

Cuproptosis: mechanisms and links with cancers

Analysis of the correlation between non-alcoholic fatty liver disease and the risk of colorectal neoplasms

Iron-Sulfur Clusters: A Key Factor of Regulated Cell Death in Cancer

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