“… 495 Multimedia models integrate the fate and transport processes across multiple compartments to assess the overall environmental behavior of pollutants on regional to global scales. 490 Pharmacokinetic models focus on the uptake, distribution, metabolism, and elimination of pollutants within organisms. These models draw from the findings of laboratory and field experiments to represent the physicochemical, mineralogical, and hydraulic properties of ECs, adsorption-desorption, chemical/biological transformation, and their retention in and exchange across environmental compartments.…”