Molecular characterization of a new fish specific chemokine CXCL_F6 in large yellow croaker (Larimichthys crocea) and its role in inflammatory response

Mu, Yinnan; Zhou, Shimin; Ding, Ning; Ao, Jingqun; Chen, Xinhua

doi:10.1016/j.fsi.2018.10.068

Cited by 15 publications

(2 citation statements)

References 35 publications

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“…Combined our results, we supposed that CXCL played an important defensive role in different tissues of tilapia against Streptococcus at the early stage. Studies have shown that CXCL exerted significant roles in regulating immune cells migration and activation such as B lymphocytes and macrophages ( Schwenteit et al, 2013 ; Mu et al, 2019 ). This result indicated that after being infected by Streptococcus , macrophages and B lymphocytes reached the inflammation area under the mediation and activation of CXCL 10 and C-C chemokine 19 in the intestine.…”

Section: Discussionmentioning

confidence: 99%

Comparative Transcriptomic Analysis Reveals the Regulated Expression Profiles in Oreochromis niloticus in Response to Coinfection of Streptococcus agalactiae and Streptococcus iniae

et al. 2022

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Tilapia (Oreochromis sp.) is one of the important economical fishes in the world. Streptococcosis is commonly found in tilapia, causing severe and devastating effects in tilapia cultures. Streptococcus agalactiae and Streptococcus iniae are the predominant pathogens causing tilapia streptococcosis. To understand the molecular mechanisms underlying differential streptococcal infection patterns, Nile tilapias (Oreochromis niloticus) were infected by 1 × 107 CFU/mL S. agalactiae, 1 × 107 CFU/mL S. iniae, and 1 × 107 CFU/mL S. agalactiae and S. iniae (1:1), respectively, and transcriptome analysis was conducted to the intestine samples of Nile tilapia (Oreochromis niloticus) at 6, 12, 24 h, and 7 days post-infection. A total of 6,185 genes that differentially expressed among groups were identified. Eight differentially expressed genes (DEGs) including E3 ubiquitin-protein ligase TRIM39-like, C-X-C motif chemokine 10-like(CXCL 10), C-C motif chemokine 19-like, interleukin-1 beta-like, IgM heavy chain VH region, partial, IgG Fc-binding protein, proteasome subunit beta type-8 (PSMB8), and ATP synthase F(0) complex subunit B1, mitochondrial that involved in the immune system were selected, and their expression levels in the coinfection group were significantly higher than those in either of the single infection groups. These genes were associated with four different KEGG pathways. Additionally, the differential expression of eight DEGs was validated by using the RT-qPCR approach, and their immunological importance was discussed. The results provided insights into the responses of tilapia against S. agalactiae and S. iniae at the transcriptome level, promoting our better understanding of immune responses for aquatic animal against Streptococcus.

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Section: Discussionmentioning

confidence: 99%

Comparative Transcriptomic Analysis Reveals the Regulated Expression Profiles in Oreochromis niloticus in Response to Coinfection of Streptococcus agalactiae and Streptococcus iniae

et al. 2022

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“…Numerous fish chemokines have been found in recent years, and their roles overlap almost entirely with those of lymphocytes. Apart from recruiting and activating leukocytes to act on the site of infection and participate in the immune response ( 21 , 22 ), fish chemokines also play important roles in stress response ( 23 ), tentacle development ( 24 ), embryo development and angiogenesis, etc. ( 25 , 26 ).…”

Section: Introductionmentioning

confidence: 99%

LcCCL28-25, Derived from Piscine Chemokine, Exhibits Antimicrobial Activity against Gram-Negative and Gram-Positive Bacteria In Vitro and In Vivo

et al. 2022

Microbiol Spectr

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Advances in chemokines of teleost fish species

Liu

2024

Aquaculture and Fisheries

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Molecular characterization of a new fish specific chemokine CXCL_F6 in large yellow croaker (Larimichthys crocea) and its role in inflammatory response

Cited by 15 publications

References 35 publications

Comparative Transcriptomic Analysis Reveals the Regulated Expression Profiles in Oreochromis niloticus in Response to Coinfection of Streptococcus agalactiae and Streptococcus iniae

Comparative Transcriptomic Analysis Reveals the Regulated Expression Profiles in Oreochromis niloticus in Response to Coinfection of Streptococcus agalactiae and Streptococcus iniae

LcCCL28-25, Derived from Piscine Chemokine, Exhibits Antimicrobial Activity against Gram-Negative and Gram-Positive Bacteria In Vitro and In Vivo

Advances in chemokines of teleost fish species

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