Molecular characterization of adenovirus circulating in Central and South America during the 2006–2008 period

Garcia, Josefina; Sovero, Merly; Laguna-Torres, V. Alberto; Gómez, Jorge; Chicaiza, Wilson; Barrantes, Melvin; Sanchez, Felix; Jimenez, Mirna; Comach, Guillermo; Rivera, Ivette Lorenzana de; Agudo, Roberto; Arango, Ana E.; Barboza, Alma; Aguayo, Nicolás; Kochel, Tadeusz J.

doi:10.1111/j.1750-2659.2009.00107.x

Cited by 11 publications

(19 citation statements)

References 16 publications

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“…Overall, five HAdV species and at least 21 distinct genotypes were identified over the study period. Species C and B viruses predominated, mirroring findings of other studies of childhood ARI in both developed and resource limited countries of North and South America, Europe, Africa, and Asia . Species C HAdVs comprised over half of the detections among camp patients, with most detections present at low virus loads.…”

Section: Discussionsupporting

confidence: 78%

“…HAdV‐B16 was originally isolated in Saudi Arabia in 1955 from a conjunctivitis case and has been isolated from a cluster of hospitalized patients with Reyeʼs‐syndrome‐like illness and pneumonia in Arkansas in 1981 and recovered from military recruits with ARI in Egypt between 1999 and 2002 . Otherwise, large surveys of HAdV ARI from multiple countries in Europe, Asia, and the Americas failed to identify this virus …”

Section: Discussionmentioning

confidence: 99%

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Reassessment of high prevalence human adenovirus detections among residents of two refugee centers in Kenya under surveillance for acute respiratory infections

Schneider

et al. 2018

Journal of Medical Virology

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Human adenoviruses (HAdVs) were previously detected at high prevalence by real‐time reverse transcription‐polymerase chain reaction (rRT‐PCR) in the upper respiratory tract of residents of two Kenyan refugee camps under surveillance for acute respiratory infection (ARI) between October 2006 and April 2008. We sought to confirm this finding and characterize the HAdVs detected. Of 2148 respiratory specimens originally tested, 511 (23.8%) screened positive for HAdV and 510 were available for retesting. Of these, 421 (82.4%) were confirmed positive by repeat rRT‐PCR or PCR and sequencing. Other respiratory viruses were codetected in 55.8% of confirmed HAdV‐positive specimens. Species B and C viruses predominated at 82.8%, and HAdV‐C1, ‐C2, and ‐B3 were the most commonly identified types. Species A, D, and F HAdVs, which are rarely associated with ARI, comprised the remainder. Viral loads were highest among species B HAdVs, particularly HAdV‐B3. Species C showed the widest range of viral loads, and species A, D, and F were most often present at low loads and more often with codetections. These findings suggest that many HAdV detections were incidental and not a primary cause of ARI among camp patients. Species/type, codetections, and viral load determinations may permit more accurate HAdV disease burden estimates in these populations.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Reassessment of high prevalence human adenovirus detections among residents of two refugee centers in Kenya under surveillance for acute respiratory infections

Schneider

et al. 2018

Journal of Medical Virology

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“…Data on antiviral resistance patterns [19] and adenovirus [14] obtained in Ecuador during the period reported in this paper has been reported previously.…”

Section: Introductionmentioning

confidence: 56%

Sentinel Surveillance of Influenza-Like-Illness in Two Cities of the Tropical Country of Ecuador: 2006–2010

et al. 2011

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BackgroundTropical countries are thought to play an important role in the global behavior of respiratory infections such as influenza. The tropical country of Ecuador has almost no documentation of the causes of acute respiratory infections. The objectives of this study were to identify the viral agents associated with influenza like illness (ILI) in Ecuador, describe what strains of influenza were circulating in the region along with their epidemiologic characteristics, and perform molecular characterization of those strains.Methodology/FindingsThis is a prospective surveillance study of the causes of ILI based on viral culture of oropharyngeal specimens and case report forms obtained in hospitals from two cities of Ecuador over 4 years. Out of 1,702 cases of ILI, nine viral agents were detected in 597 patients. During the time of the study, seven genetic variants of influenza circulated in Ecuador, causing six periods of increased activity. There appeared to be more heterogeneity in the cause of ILI in the tropical city of Guayaquil when compared with the Andean city of Quito.Conclusions/SignificanceThis was the most extensive documentation of the viral causes of ILI in Ecuador to date. Influenza was a common cause of ILI in Ecuador, causing more than one outbreak per year. There was no well defined influenza season although there were periods of time when no influenza was detected alternating with epidemics of different variant strains.

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“…In addition, we have determined that HAdv subgroups B, C, and E circulate within Peru and subgroup C predominated during the 2006–2008 period [28]. We also identified HAdv subgroup E in samples obtained from a conjunctivitis outbreak in Peruvian Navy personnel stationed in Lima, Peru (Virology Department, U.S.…”

Section: Introductionmentioning

confidence: 96%

Adenovirus Respiratory Tract Infections in Peru

Ampuero

Ocaña²,

Gómez

et al. 2012

PLoS ONE

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BackgroundCurrently, there is a paucity of data regarding human adenovirus (HAdv) circulation in Andean regions of South America. To address this shortcoming, we report the clinical, phylogenetic, and epidemiologic characteristics of HAdv respiratory tract infection from a large sentinel surveillance study conducted among adults and children in Peru.Methods/Principal FindingsOropharyngeal swabs were collected from participants visiting any of 38 participating health centers, and viral pathogens were identified by immunofluorescence assay in cell culture. In addition, molecular characterization was performed on 226 randomly selected HAdv samples. Between 2000 and 2010, a total of 26,375 participants with influenza-like illness (ILI) or severe acute respiratory infection (SARI) were enrolled in the study. HAdv infection was identified in 2.5% of cases and represented 6.2% of all viral pathogens. Co-infection with a heterologous virus was found in 15.5% of HAdv cases. HAdv infection was largely confined to children under the age of 15, representing 88.6% of HAdv cases identified. No clinical characteristics were found to significantly distinguish HAdv infection from other respiratory viruses. Geographically, HAdv infections were more common in sites from the arid coastal regions than in the jungle or highland regions. Co-circulation of subgroups B and C was observed each year between 2006 and 2010, but no clear seasonal patterns of transmission were detected.Conclusions/SignificanceHAdv accounted for a significant fraction of those presenting with ILI and SARI in Peru and tended to affect the younger population disproportionately. Longitudinal studies will help better characterize the clinical course of patients with HAdv in Peru, as well as determine the role of co-infections in the evolution of illness.

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Molecular characterization of adenovirus circulating in Central and South America during the 2006–2008 period

Cited by 11 publications

References 16 publications

Reassessment of high prevalence human adenovirus detections among residents of two refugee centers in Kenya under surveillance for acute respiratory infections

Reassessment of high prevalence human adenovirus detections among residents of two refugee centers in Kenya under surveillance for acute respiratory infections

Sentinel Surveillance of Influenza-Like-Illness in Two Cities of the Tropical Country of Ecuador: 2006–2010

Adenovirus Respiratory Tract Infections in Peru

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