Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray

Zeng, Fanlin; Hon, Chung-Chau; Sit, Wai Hung; Chow, Ken Y.C.; Hui, Raymond Kin Hi; Law, Ivy Ka Man; Ng, Victor Wai Lap; Yang, Xiao; Leung, Fung Ping; Wan, Jennifer M. F.

doi:10.3892/ijo.27.2.513

Cited by 20 publications

(17 citation statements)

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“…Male and female developmental trajectories are manifest in life-long sex-specific gene expression patterns (14) that are also highly tissue-specific and appear to be evolutionarily conserved. In the mouse liver, as many as 70% of genes have sexually dimorphic gene expression patterns compared to only 14% in the brain (15). Sexually dimorphic gene expression in the occipital cortex is highly conserved across several primates (16).…”

Section: Introductionmentioning

confidence: 99%

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

Suderman

Simpkin

Sharp

et al. 2017

Preprint

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Almost all species show sexual discordance in many traits and diseases. DNA methylation is known to contribute to these differences through well-established mechanisms including X-inactivation in females, imprinting and parent-of-origin effects. Here we investigate sex discordance in DNA methylation throughout childhood in a sample of 700 individuals from the Avon Longitudinal Study of Parents and Children. We show that autosomal sex-discordant methylation is widespread, affecting approximately 12,000 CpG sites at any given age, and stable; at least 8,500 sites are consistently different across all time points and a large proportion discordant in both the fetal and adult brain cortices. Just over 1,000 methylation differences change from birth to late adolescence, 90% of these between birth and around age seven. Sexually discordant CpG sites are enriched in genomic loci containing androgen but not estrogen targets and in genes involved in tissue development but not housekeeping functions. A methylation-derived sex score capturing the variance was calculated at each time point and found to be highly correlated between time points. This score is nominally associated with sex hormone levels in childhood as well as some phenotypes previously linked to sex hormone levels. These findings suggest that sex-discordant autosomal DNA methylation is widespread throughout the genome, likely due to the first androgen exposures in utero. It is then stably maintained from birth to late adolescence. Methylation variation at sex-discordant sites within the sexes, as summarized by the methylation sex score, likely reflects in utero androgen exposure which is relevant to human health.Significance StatementAlthough we know that sex hormones are critical for establishing sexual discordance, less is known about how this discordance is achieved and maintained. Here we present evidence for widespread differences in DNA methylation between male and female children. We show that most of these differences are established prenatally, likely due to the first androgen exposures in utero, and then stably maintained throughout childhood, despite extreme fluctuations in the levels of these very same hormones. Our results support a role for DNA methylation as a means for recording and maintaining the effects of exposure to sex hormones and thus to better understand sexual variation and how it is driven by the prenatal environment.

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Section: Introductionmentioning

confidence: 99%

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

Suderman

Simpkin

Sharp

et al. 2017

Preprint

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“…Recently, a microarray study presented several novel findings regarding gene expression profiles in early-stage embryos [32]. For example, fertilization leads to extensive changes in the transcript profiles, which are much greater than previously recognized, and genome activation during the 2-cell stage may be selective on a qualitative scale with genes involved in transcription and RNA processing.…”

Section: Networkmentioning

confidence: 98%

Dynamism in the Gene Expression Profile after Oocyte Activation in Mice

Jincho¹,

Kono²

2008

Journal of Mammalian Ova Research

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“…There is some evidence from clinical trials that they can improve survival (Chang, 2002). The polysaccharide complexes and extracts include constituents of Coriolus versicolor (extract is Krestin, PSK or PSP) (Zeng et al, 2005;Ito et al, 2004;Ohwada et al, 2004;Koda et al, 2003;Tsang et al, 2003;Kanazawa et al, 2004;Wong et al, 2004 andMunemoto et al, 2002;Hayakawa et al, 1997;Ogoshi et al, 1995;Mitomi et al, 1992;Nakazato et al, 1994), Ganoderma lucidum (Shao et al, 2004a;Lin, 2005;Kuo et al, 2006;Gao et al, 2003;Kodama et al, 2005a), Grifola frondosa (maitake MD-fraction) (Kodama et al, 2002(Kodama et al, , 2003(Kodama et al, , 2005aAtsuyuki et al, 2002), Astragalus membranaceus (Shao et al, 2004b), Panax ginseng (Shin et al, 2002 and2004;Han et al, 2005;Lim et al, 2004), and various other medicinal mushrooms (Ooi and Liu, 2000;Zaidman et al, 2005;Lindquist et al, 2005). Molecular mechanisms for the immunobiological functions may be through various receptors on macrophages, monocytes and NK cells, which activate NF-kB and anti-tumor cytokine secretion.…”

Section: (B) Enhancement Of Immunity (I) Herbsmentioning

confidence: 99%

The Scientific Basis of Chinese Medicine and Cancer Care: A Western Medicine Perspective

Sagar¹,

Wong²

2007

Annals of Traditional Chinese Medicine

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Traditional Chinese medicine (TCM) may be integrated with conventional Western medicine to enhance the care of patients with cancer. Recent evidence confirms a scientific basis for the use of acupuncture, herbs, diet and energy therapies. We suggest a holistic care plan based on the concepts of biological response modification, enhancement of psycho-immunological function, better symptom control, and improvement of psycho-spiritual well-being. There is enough preliminary evidence to encourage good quality clinical trials to evaluate the efficacy of integrating TCM into Western cancer care.

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Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray

Cited by 20 publications

References 0 publications

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

Dynamism in the Gene Expression Profile after Oocyte Activation in Mice

The Scientific Basis of Chinese Medicine and Cancer Care: A Western Medicine Perspective

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