Molecular characterization of dog albumin as a cross-reactive allergen

Spitzauer, Susanne; Schweiger, Christian; Sperr, Wolfgang R.; Pandjaitan, Budhi; Valent, Peter; Mühl, Sonja; Ebner, Christof; Scheiner, Otto; Kraft, Dietrich; Rumpold, Helmut; Valenta, Rudolf

doi:10.1016/s0091-6749(94)70073-7

Cited by 95 publications

(72 citation statements)

References 27 publications

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“…Albumins have been recognized as relevant crossreactive allergens (446). Moreover, there are common, as well as species-restricted, IgE epitopes of the major cat and dog allergens (447).…”

Section: Other Mitesmentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,867

1,761

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“…Albumins have been recognized as relevant crossreactive allergens (446). Moreover, there are common, as well as species-restricted, IgE epitopes of the major cat and dog allergens (447).…”

Section: Other Mitesmentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,867

1,761

View full text Add to dashboard Cite

“…[13][14][15][16] Despite their ubiquitous presence on allergy skin test panels and their frequent inclusion in IT mixtures, dog allergens have only been assessed for stability in one investigation involving short exposures (up to 1 hour) to dry heat (up to 140°C); to our knowledge, no studies have been reported regarding their compatibilities with other, specifically protease-rich, extracts. 17 The formulation of IT mixtures containing dog or other extracts presents a formidable challenge to clinicians who want to balance optimal extract doses with minimal numbers of injections, and it is not surprising to find extract combinations with uncertain allergen stabilities, such as those investigated in this study, being prepared and administered on a regular basis in many allergy clinics.…”

Section: Discussionmentioning

confidence: 99%

Stability and mixing compatibility of dog epithelia and dog dander allergens

Grier¹,

LeFevre²,

Duncan³

et al. 2009

Annals of Allergy, Asthma & Immunology

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“…Recently, some authors have noticed that allergy to cats or dogs seemed to be an important risk factor for laboratory animal allergy from the result of adverse reactions between these allergens [4]. Albumins occur at high concentrations in animal hair/dander extracts and represent important cross-reactive allergens for 30% of patients with animal allergy [5,6]. Patients allergic to animals frequently display IgE reactivity to The present study assumed that laboratory animal allergens had been present at home because of passive transport by parents who had been in contact with the allergens.…”

Section: Discussionmentioning

confidence: 99%

Paralysis of ventilated newborn babies does not influence resistance of the total respiratory system

Burger¹,

Fanconi²,

Simma³

1999

Eur Respir J

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A. Krakowiak, B. Szulc, P. Go Â rski Allergy to laboratory animals in children of parents occupationally exposed to mice, rats and hamsters. A. Krakowiak, B. Szulc, P. Go Ârski. #ERS Journals Ltd 1999. ABSTRACT: Sensitization to laboratory animals (LA) has a high prevalence among laboratory workers. It is unknown whether transportation of LA allergens can be a risk factor for sensitization of subjects outside the laboratory environment. The aim of the study was to investigate the prevalence of sensitization to LA among children whose parents were and were not occupationally exposed to LA.The first group consisted of 50 children (age 12.34.3 yrs) whose parents were occupationally exposed to mice, rats and hamsters. The second group consisted of 40 children (age (meanSD) 10.83.0 yrs) whose parents were not occupationally exposed to LA. Children having LA at home were eliminated from the study. All children responded to a questionnaire, underwent spirometry and were also tested with skin prick tests with the use of common allergens and prick tests with hair extracts from mouse, hamster and rat. Total immunoglobulin (Ig)E levels and the presence of specific IgE against LA were also estimated.Children of parents occupationally exposed to LA presented significantly more positive skin prick tests against allergens from the hair of laboratory animals compared to children of nonexposed parents. Five children from the first group were also found to have specific IgE against LA, with three of these five children complaining of rhinitis and cough while visiting their parents' workplace.It is concluded that the observed increased sensitization to laboratory animals among children of occupationally exposed parents could be the result of poor hygienic conditions at their parents' workplace. Hence, parents' job seems to be an additional risk factor of sensitization and should be taken into consideration when recording an allergic history.

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Molecular characterization of dog albumin as a cross-reactive allergen

Cited by 95 publications

References 27 publications

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Stability and mixing compatibility of dog epithelia and dog dander allergens

Paralysis of ventilated newborn babies does not influence resistance of the total respiratory system

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