2009
DOI: 10.1016/j.jinf.2009.06.001
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Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region

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Cited by 27 publications
(21 citation statements)
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“…Higher GMTs in response to a third dose did not increase the percentage of subjects with hSBA titers ≥1:4 against NadA or fHbp, and it is unclear whether there is any clinical benefit of higher titers in response to the OMV component. Similar results were observed at 1 month after the 2-dose schedule both in the UK among 18-24 year old university students (99-100% achieved hSBA titers ≥1:4 against fHbp, NadA and PorA1.4) [47] and among [11][12][13][14][15][16][17] year old adolescents in Canada and Australia (99-100% achieved hSBA titers ≥1:5 against fHbp and NadA; 75% achieved hSBA titers ≥1:5 against PorA1.4) [43]. At two weeks after the second vaccination, 100% of subjects in the Canada and Australia study had hSBA titers ≥1:5 against strains fHbp and NadA; the percentage of subjects with hSBA ≥1:5 against strain NZ OMV at two weeks was higher compared to 1 month after vaccination (84-96%, 64-80%, respectively) [43].…”
Section: Responses To Various Vaccination Schedulessupporting
confidence: 74%
See 1 more Smart Citation
“…Higher GMTs in response to a third dose did not increase the percentage of subjects with hSBA titers ≥1:4 against NadA or fHbp, and it is unclear whether there is any clinical benefit of higher titers in response to the OMV component. Similar results were observed at 1 month after the 2-dose schedule both in the UK among 18-24 year old university students (99-100% achieved hSBA titers ≥1:4 against fHbp, NadA and PorA1.4) [47] and among [11][12][13][14][15][16][17] year old adolescents in Canada and Australia (99-100% achieved hSBA titers ≥1:5 against fHbp and NadA; 75% achieved hSBA titers ≥1:5 against PorA1.4) [43]. At two weeks after the second vaccination, 100% of subjects in the Canada and Australia study had hSBA titers ≥1:5 against strains fHbp and NadA; the percentage of subjects with hSBA ≥1:5 against strain NZ OMV at two weeks was higher compared to 1 month after vaccination (84-96%, 64-80%, respectively) [43].…”
Section: Responses To Various Vaccination Schedulessupporting
confidence: 74%
“…kissing, sharing drinks), smoking, and sleep deprivation [11][12][13]. While incidence peaks in adolescents are common in countries like the US, Canada, and Europe, some countries in Latin America do not exhibit such a prominent peak in its adolescent population [14][15][16][17]. This observation may be in part due to differences in college/university systems where, for example, dormitory housing is more common in the US but not in Chile.…”
Section: Introductionmentioning
confidence: 99%
“…The lower frequency of serogroup Y and overall meningococcal carriage was reflected in a decrease in invasive meningococcal cases between 1998 and 2007 12. Serogroup Y disease has also been reported in South America, South Africa, Europe, and Israel 36,37. Most of the serogroup Y disease increase is associated with ST-23 and ST-167 clonal complexes 36,38.…”
Section: Changing Global Epidemiologymentioning
confidence: 94%
“…The genotype was defined as 3-100:P1. (8)(9)(10)(11), suggesting that a common strain circulating in South America underwent a mutational event that led to the expression of the mixed polysaccharides described here. The monitoring of such isolates has implications for routine meningococcal disease surveillance.…”
mentioning
confidence: 85%