Molecular characterization of pulmonary defenses against bacterial invasion in allergic asthma: The role of Foxa2 in regulation of β-defensin 1

Wei, Chuanqi; Tang, Xuemei; Wang, Faping; Li, Yan; Sun, Lin; Luo, Feng

doi:10.1371/journal.pone.0226517

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Additionally, β-defensins have been shown to promote epithelial proliferation and differentiation during wound healing [ 7 , 13 , 14 ]. Wei et al [ 15 ] reported that different types of β-defensins or lysozymes might work together to defend against potential pathogens.…”

Section: Resultsmentioning

confidence: 99%

Investigation of serum beta-defensin-1 level in calves with coccidiosis

Koçhan

2021

J Adv Vet Anim Res

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Objective: Coccidiosis is a protozoan infection that can result in hemorrhagic diarrhea, depression, weakness, weight loss, and even mortality in young animals. β-defensin-1 is an antimicrobial peptide produced largely by epithelial cells in the skin and mucosa. It possesses antifungal, antibacterial, antiparasitic, and antiviral properties. The goal of this study was to evaluate how β-defensin-1 levels changed in coccidiosis-infected calves. Materials and Methods: The sample included 10 coccidiosis-positive calves and 7 healthy calves, for a total of 17 calves of diverse breeds and older than 15 days. To assess the level of β-defensin-1, blood samples were obtained from the vena jugularis of the animals. The concentrations of β-defensin-1 in the serum were measured using a commercial ELISA kit. Results: Although the serum β-defensin-1 level decreased in infected animals, the drop was not statistically significant when compared to the control group. Conclusion: According to the study’s findings, there was no significant change in the serum β-defensin-1 level in coccidiosis-infected calves. We believe that it will be advantageous to conduct additional studies with a larger sample size in order to acquire more precise results.

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Section: Resultsmentioning

confidence: 99%

Investigation of serum beta-defensin-1 level in calves with coccidiosis

Koçhan

2021

J Adv Vet Anim Res

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“…Low Foxa2 expression in lung is associated with Th2 inflammation and cytokine production, and over-production of mucus in humans and mice ( 7 , 12 , 14 , 48 ). Here, we found that Foxa2 expression was downregulated in lung tissue and control lung CD4 T-cells on induction of AAD by papain sensitisation.…”

Section: Discussionmentioning

confidence: 99%

The Pioneer Transcription Factor Foxa2 Modulates T Helper Differentiation to Reduce Mouse Allergic Airway Disease

et al. 2022

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Foxa2, a member of the Forkhead box (Fox) family of transcription factors, plays an important role in the regulation of lung function and lung tissue homeostasis. FOXA2 expression is reduced in the lung and airways epithelium of asthmatic patients and in mice absence of Foxa2 from the lung epithelium contributes to airway inflammation and goblet cell hyperplasia. Here we demonstrate a novel role for Foxa2 in the regulation of T helper differentiation and investigate its impact on lung inflammation. Conditional deletion of Foxa2 from T-cells led to increased Th2 cytokine secretion and differentiation, but decreased Th1 differentiation and IFN-γ expression in vitro. Induction of mouse allergic airway inflammation resulted in more severe disease in the conditional Foxa2 knockout than in control mice, with increased cellular infiltration to the lung, characterized by the recruitment of eosinophils and basophils, increased mucus production and increased production of Th2 cytokines and serum IgE. Thus, these experiments suggest that Foxa2 expression in T-cells is required to protect against the Th2 inflammatory response in allergic airway inflammation and that Foxa2 is important in T-cells to maintain the balance of effector cell differentiation and function in the lung.

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“…Airway epithelial-derived host defence peptides (HDPs) are a group of antimicrobial agents released into the extracellular space in response to pathogens [ 30 ]. Altered secretion of certain HDPs such as β-defensins has been observed in patients with asthma and patients with COPD as well as in response to noxious particles and was associated with pathogenesis of the diseases [ 135 , 160 – 162 ]. Whole diesel exhaust was shown to downregulate host defence peptide β-defensin-2 in AECs from patients with COPD stimulated with Haemophilus influenzae [ 136 ].…”

Section: Air Pollutant-induced Airway Epithelial Dysfunction and Susc...mentioning

confidence: 99%

Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD

et al. 2022

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Chronic exposure to environmental pollutants is a major contributor to the development and progression of obstructive airway diseases, including asthma and COPD. Understanding the mechanisms underlying the development of obstructive lung diseases upon exposure to inhaled pollutants will lead to novel insights into the pathogenesis, prevention and treatment of these diseases. The respiratory epithelial lining forms a robust physicochemical barrier protecting the body from inhaled toxic particles and pathogens. Inhalation of airborne particles and gases may impair airway epithelial barrier function and subsequently lead to exaggerated inflammatory responses and airway remodelling, which are key features of asthma and COPD. In addition, air pollutant-induced airway epithelial barrier dysfunction may increase susceptibility to respiratory infections, thereby increasing the risk of exacerbations and thus triggering further inflammation. In this review, we discuss the molecular and immunological mechanisms involved in physical barrier disruption induced by major airborne pollutants and outline their implications in the pathogenesis of asthma and COPD. We further discuss the link between these pollutants and changes in the lung microbiome as a potential factor for aggravating airway diseases. Understanding these mechanisms may lead to identification of novel targets for therapeutic intervention to restore airway epithelial integrity in asthma and COPD.

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Molecular characterization of pulmonary defenses against bacterial invasion in allergic asthma: The role of Foxa2 in regulation of β-defensin 1

Cited by 7 publications

References 27 publications

Investigation of serum beta-defensin-1 level in calves with coccidiosis

Investigation of serum beta-defensin-1 level in calves with coccidiosis

The Pioneer Transcription Factor Foxa2 Modulates T Helper Differentiation to Reduce Mouse Allergic Airway Disease

Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD

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