Molecular Classification of Iraqi Breast Cancer Patients and Its Correlation with Patients’ Profile

Abstract

Background: Breast cancer is a complex, multifaceted disease encompassing a great variety of entities that show considerable variation in clinical, morphological and molecular attributes. Objective: The aim of this study to evaluate patients' molecular profile (Estrogen receptor, Progesterone receptor, HER2/neu and Ki-67). Patients & Methods: This is a cross-sectional descriptive study was done in Baghdad oncology teaching hospital from December 2015 to April 2016, carried on 100 breast cancer female patients with their age range from 27 to 73 years old and with their histopathology reports and (IHC) results. Results: The highest incidence of breast cancer among patients in 5th (40-49 years) and 6th (50-59 years) decades of life both groups are (32%), estrogen and progesterone values were observed (74% and 75% respectively) and 69 patients (69%) with Ki-67 ≥14. Conclusions: Most of the breast cancer patients in the current study were estrogen and progesterone (Hormonal) positive, and Luminal B-like was the most common molecular subtype (53%) due to high Ki-67 index. There was a strong correlation between estrogen and progesterone in the studied patients with highly significant P value <0.0001.

Assessment of dose‐volume histogram statistics using three‐dimensional conformal techniques in breast cancer adjuvant radiotherapy treatment

“…These findings also assist the ongoing research on 3DCRT delivery in our region. The findings confirm several other studies conducted in Iraq 13–17 . Age is an essential factor in the occurrence and management of BC 18 .…”

“…Iraq. [13][14][15][16][17] Age is an essential factor in the occurrence and management of BC. 18 In the research comparing women from Iraq and Britain, the mean age was higher by over 15 years than what the present results…”

The Prevalence of Human Papilloma Virus among Breast Cancer Women in Relation with IL-8 Level in Kirkuk Province

“…As stated by American cancer society, age of the patient is an important factor both for the occurrence and management of the disease with 95% of all new breast cancer cases developed in women aged 40 years or older[32], which was along with our results. Also, our result was in relation to Al-Khafaji AH[33] which detailed that the peak…”

Breast Cancer and Mitochondrial Dna Mutations in Kurdish Women: A Case-Control Study From Sulaymaniyah, Iraq.

“…The observed variation in the impact of mitochondrial genome on carcinogenic process suggests that other factors such as the individual physiology, geographical location and ethnicity may have a role in shaping the final picture [26][27][28] .…”