Molecular Clock Regulates Daily α1–2-Fucosylation of the Neural Cell Adhesion Molecule (NCAM) within Mouse Secondary Olfactory Neurons

Kondoh, Daisuke; Tateno, Hiroaki; Hirabayashi, Jun; Yasumoto, Yuki; Nakao, Reiko; Oishi, Katsutaka

doi:10.1074/jbc.m114.571141

Cited by 4 publications

(10 citation statements)

References 40 publications

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“…7 a). Alpha1-2Fuc glycan mediates neuronal functions, affects neuronal morphology [Pohle et al, 1987;Krug et al, 1991Krug et al, , 1994Matthies et al, 1996;Lorenzini et al, 1997;Kalovidouris et al, 2005;Murrey et al, 2006] and also might control olfactory functions according to developmental stage [Murrey et al, 2009] and circadian rhythms [Kondoh et al, 2014]. We showed that most receptor cells arranged at the basal region of the OE possess dendrites and axons including α1-2Fuc glycan; this agrees with the findings reported by Ducray et al [1999].…”

Section: Uea-i Reaction In the Aobsupporting

confidence: 83%

“…For example, we showed that α1-2Fuc glycan preferentially locates in the LOT and in the glomerular layer of the AOB of the ICR mouse [Kondoh et al, 2014] whereas other study groups have not found that UEA-I reacts with the mouse LOT. Because of the potential of α1-2Fuc glycan described above, identifying the histological components and cell types that α1-2Fuc glycan modifies in the olfactory system is important.…”

mentioning

confidence: 78%

“…Therefore, glycoconjugates including α1-2Fuc glycan are located in both local circuits of the MOB and the secondary pathway of the olfactory system. Neural cell adhesion molecule (NCAM) is a highly glycosylated protein [Liedtke et al, 2001] and is apparently the main core protein of α1-2Fuc glycan in the mouse olfactory bulb [Pestean et al, 1995;Murrey et al, 2009;Kondoh et al, 2014]; it plays critical roles in neurite outgrowth and synaptic formation, especially in the olfactory bulb [Treloar et al, 1997;Zamze et al, 1998;Perlson et al, 2013]. Because α1-2Fuc glycan also mediates neuronal functions and affects neuronal morphology [Pohle et al, 1987;Krug et al, 1991Krug et al, , 1994Matthies et al, 1996;Lorenzini et al, 1997;Kalovidouris et al, 2005;Murrey et al, 2006], α1-2Fuc attachments might affect NCAM function and mediate both major adjustments within the olfactory pathway and minor adjustments within the MOB.…”

Section: Uea-i Reaction In the Aobmentioning

confidence: 99%

“…Although α1-2Fuc glycan has been histochemically localized in the mouse olfactory system using Ulex europaeus agglutinin-I (UEA-I) [Lundh et al, 1989;Ducray et al, 1999;Salazar et al, 2001;Lipscomb et al, 2002Lipscomb et al, , 2003Salazar and Sánchez Quinteiro, 2003;Murrey et al, 2009;Barrios et al, 2014;Kondoh et al, 2014], the findings are diverse. For example, we showed that α1-2Fuc glycan preferentially locates in the LOT and in the glomerular layer of the AOB of the ICR mouse [Kondoh et al, 2014] whereas other study groups have not found that UEA-I reacts with the mouse LOT.…”

mentioning

confidence: 99%

“…Neuronal functions, such as learning and memory, as well as neuronal morphological changes, including neurite outgrowth and synaptic plasticity are mediated by α1-2 fucose (α1-2Fuc) glycan [Pohle et al, 1987;Krug et al, 1991Krug et al, , 1994Matthies et al, 1996;Lorenzini et al, 1997;Kalovidouris et al, 2005;Murrey et al, 2006]. Murrey et al [2009] found that development of the olfactory bulb is defective in mice with a deficiency of α1-2-specific fucosyltransferase 1, and we recently showed that the amount of α1-2Fuc glycan in the olfactory bulb diurnally fluctuates via rhythmic expression of the Fut1 gene [Kondoh et al, 2014]. Therefore, α1-2Fuc glycan might control functional changes in the olfactory system during developmental stages and circadian variations.…”

mentioning

confidence: 99%

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Localization of α1-2 Fucose Glycan in the Mouse Olfactory Pathway

Kondoh

Kamikawa²,

Sasaki³

et al. 2016

Cells Tissues Organs

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Glycoconjugates in the olfactory system play critical roles in neuronal formation, and α1-2 fucose (α1-2Fuc) glycan mediates neurite outgrowth and synaptic plasticity. Histochemical findings of α1-2Fuc glycan in the mouse olfactory system detected using Ulex europaeus agglutinin-I (UEA-I) vary. This study histochemically assessed the main olfactory and vomeronasal pathways in male and female ICR and C57BL/6J mice aged 3-4 months using UEA-I. Ulex europaeus agglutinin-I reacted with most receptor cells arranged mainly at the basal region of the olfactory epithelium. The olfactory nerve layer and glomerular layer of the main olfactory bulb were speckled with positive UEA-I staining, and positive fibers were scattered from the glomerular to the internal plexiform layer. The lateral olfactory tract and rostral migratory stream were also positive for UEA-I. We identified superficial short-axon cells, interneurons of the external plexiform layer, external, middle and internal tufted cells, mitral cells and granule cells as the origins of the UEA-I-positive fibers in the main olfactory bulb. The anterior olfactory nucleus, anterior piriform cortex and olfactory tubercle were negative for UEA-I. Most receptor cells in the vomeronasal epithelium and most glomeruli of the accessory olfactory bulb were positive for UEA-I. Our findings indicated that α1-2Fuc glycan is located within the primary and secondary, but not the ternary, pathways of the main olfactory system, in local circuits of the main olfactory bulb and within the primary, but not secondary, pathway of the vomeronasal system.

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Section: Uea-i Reaction In the Aobsupporting

confidence: 83%

mentioning

confidence: 78%

Section: Uea-i Reaction In the Aobmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Localization of α1-2 Fucose Glycan in the Mouse Olfactory Pathway

Kondoh

Kamikawa²,

Sasaki³

et al. 2016

Cells Tissues Organs

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Age-dependent decrease in glomeruli and receptor cells containing α1–2 fucose glycan in the mouse main olfactory system but not in the vomeronasal system

2018

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Receptor cells of the olfactory epithelium (OE) and vomeronasal organ (VNO) project axons to glomeruli in the main olfactory bulb (MOB) and accessory olfactory bulb (AOB), respectively and undergo continuous turnover throughout life. Alpha1-2 fucose (α1-2Fuc) glycan mediates neurite outgrowth and synaptic plasticity and plays important roles in the formation of the olfactory system during development. We previously confirmed the localization of α1-2Fuc glycan in the olfactory system of 3- to 4-month-old mice but whether such localization persists throughout life remains unknown. Here, the MOB, AOB, OE and VNO of 1-, 3- and 8-month-old mice were histochemically examined using Ulex europaeus agglutinin-I (UEA-I) that specifically binds to α1-2Fuc glycan. Binding sites for UEA-I in the MOB were similar among all age groups but the ratio of UEA-I-positive glomeruli significantly decreased with aging. The frequency of UEA-I-positive receptor cells in the OE of the two older groups was also significantly lower than that of 1-month-old mice. On the other hand, UEA-I binding in the AOB and VNO did not significantly differ among all three groups. These findings suggest that the primary pathway of the main olfactory system requires the role of α1-2Fuc glycan in young mice rather than old mice, while the vomeronasal pathway equally requires this glycan in both young and old mice.

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Regulation and function of extra‐SCN circadian oscillators in the brain

2020

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Most organisms evolved endogenous, so called circadian clocks as internal timekeeping mechanisms allowing them to adapt to recurring changes in environmental demands brought about by 24-hour rhythms such as the light-dark cycle, temperature variations or changes in humidity. The mammalian circadian clock system is based on cellular oscillators found in all tissues of the body that are organized in a hierarchical fashion. A master pacemaker located in the suprachiasmatic nucleus (SCN) synchronizes peripheral tissue clocks and extra-SCN oscillators in the brain with each other and with external time. Different time cues (so called Zeitgebers) such as light, food intake, activity and hormonal signals reset the clock system through the SCN or by direct action at the tissue clock level. While most studies on non-SCN clocks so far have focused on peripheral tissues, several extra-SCN central oscillators were characterized in terms of circadian rhythm regulation and output. Some of them are directly innervated by the SCN pacemaker, while others receive indirect input from the SCN via other neural circuits or extra-brain structures. The specific physiological function of these non-SCN brain oscillators as well as their role in the regulation of the circadian clock network remains understudied. In this review we summarize our current knowledge about the regulation and function of extra-SCN circadian oscillators in different brain regions and devise experimental approaches enabling us to unravel the organization of the circadian clock network in the central nervous system. K E Y W O R D S brain, circadian clock, clock gene, CNS, entrainment 2 of 14 | BEGEMANN Et Al.major depression or cardiovascular disorders are promoted by chronodisruption, that is, the perturbation of internal clock function or of the alignment of these clocks with external time. 4 Besides shift work, other chronodisruptive factors are sleep curtailment, high-energy diets or mistimed eating patterns, and nocturnal light pollution. 5,6 Resetting stimuli (eg light)Resetting stimuli (eg PUFAs) Resetting stimuli (eg NO/CO) RORE D-box E-box CLOCK BMAL1 REV-ERBs RORs DBP NFIL3 PERs CRYs CCGsHow to cite this article: Begemann K, Neumann A-M, Oster H. Regulation and function of extra-SCN circadian oscillators in the brain. Acta Physiol.

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Molecular Clock Regulates Daily α1–2-Fucosylation of the Neural Cell Adhesion Molecule (NCAM) within Mouse Secondary Olfactory Neurons

Cited by 4 publications

References 40 publications

Localization of α1-2 Fucose Glycan in the Mouse Olfactory Pathway

Localization of α1-2 Fucose Glycan in the Mouse Olfactory Pathway

Age-dependent decrease in glomeruli and receptor cells containing α1–2 fucose glycan in the mouse main olfactory system but not in the vomeronasal system

Regulation and function of extra‐SCN circadian oscillators in the brain

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