Molecular cloning of the seventh component of complement in rainbow trout

Zarkadis, Ioannis K.; Duraj, Stella; Chondrou, Maria

doi:10.1016/j.dci.2004.06.006

Cited by 32 publications

(11 citation statements)

References 17 publications

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“…In the present study, C7-1 transcripts were detected in all tissues studied. This extended previous results where no C7-1 transcripts were detected in the trout spleen and kidney using conventional RTePCR [33]. The discovery of C7-2 did, however, reveal a different expression profile which coincided with our results by the presence of C7-2 in the spleen and kidney [34].…”

Section: Discussionsupporting

confidence: 81%

Extrahepatic synthesis of complement components in the rainbow trout (Oncorhynchus mykiss)

Løvoll

Dalmo

Bøgwald

2007

Fish & Shellfish Immunology

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Section: Discussionsupporting

confidence: 81%

Extrahepatic synthesis of complement components in the rainbow trout (Oncorhynchus mykiss)

Løvoll

Dalmo

Bøgwald

2007

Fish & Shellfish Immunology

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“…Several serum complement isoforms have been discovered in fish, namely C3 [47], C4 [48], C5 [49], C7 [50], C8 [51]. In addition to the reported gene sequences, and to the ''in vitro'' studies of complement activities, some antibodies have been prepared against complement subunits [52].…”

Section: Complement Activitiesmentioning

confidence: 99%

Cell markers and determinants in fish immunology

Randelli

Buonocore

Scapigliati

2008

Fish & Shellfish Immunology

103

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Despite the impressive increase in the cloning and expression of genes encoding fish immunoregulatory molecules, the knowledge on "in vivo" and "in vitro" functional immunology of the corresponding peptide products is still at an initial stage. This is partly due to the lacking of specific markers for immunoregulatory peptides, that represent an indispensible tool to dissect immune reactions and to trace the fate of cellular events downstream of the activation. In this review we summarise the available information on functional immune activities of some teleost species and discuss the obtained data in an evolutionary and applied context.

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“…More recently it has been shown that Japanese flounder perforin is functionally similar to those of mammals in being part of the antiviral defence system [16]. Over the last few years, we have also isolated and characterized the terminal complement components (C6, C7, C8, and C9) genes in rainbow trout [21][22][23][24][25][26], which along with perforin belong to the same MACPF superfamily. In order to gain further insight into the evolution of the MACPF family, we have isolated and characterized the perforin gene from rainbow trout.…”

Section: Resultsmentioning

confidence: 97%