Molecular Complexes of Monoammonium Glycyrrhizinate with Alphahederin and Hederasaponin C

Yakovishin, L. A.; Гришковец, В. И.; Корж, Е Н

doi:10.2174/1570178612666141230234729

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Cited by 7 publications

References 10 publications

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Molecular complexes of triterpene glycosides with 5-fluorouracil sodium salt: spectral characterization and cytotoxic activity

Gibadullina,

Yakovishin,

Grishkovets

et al. 2024

Russ Chem Bull

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Molecular complexes of triterpene glycosides with 5-fluorouracil sodium salt: spectral characterization and cytotoxic activity

Gibadullina,

Yakovishin,

Grishkovets

et al. 2024

Russ Chem Bull

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Molecular complexes of triterpenes and their glycosides with cyclodextrins: Recent advances and application prospects

Yakovishin

2024

Studies in Natural Products Chemistry

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Molecular complex of salicylic acid with glycyram

Yakovishin

2020

AIP Conference Proceedings

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Salicylic acid (SalA) is the simplest aromatic carboxylic acid, which had shown analgesic, antipyretic, and anti-inflammatory activity. SalA is one of the most famous dermatological drugs with keratolytic, bacteriostatic, fungicidal, and photoprotective properties 1 .However, the use of SalA in medical practice is limited by its toxicity (salicylism) 1 . The great interest to molecular complexes of triterpene glycosides with different drugs is caused by the possibility to reduce of drugs doses, increase in bioavailability, decrease in drugs toxicity, and expansion of pharmacological activity spectrum of drugs and triterpene glycosides 2, 3 . The complexes of glycyrrhizic acid and its monoammonium salt (glycyram, GC) are the most studied 2, 3 . Molecular complex of SalA with GC is not described. The use of GC can potentially decrease in SalA toxicity and improve its bioavailability.A new molecular complex of GC with SalA in a 1:1 molar ratio was obtained. The SalA-GC complex composition was determined by the method of isomolar series. Absorption spectrum of isomolar series for mixtures of GC with SalA has isosbestic points at 238 and 282 nm.The molecular complexation of SalA with GC was studied by ATR FT-IR spectroscopy. It was shown that hydrogen bonds are formed between OH group of SalA carboxyl and C=O group of GC carboxyl or OH groups of GC carbohydrate residues: -С=ОGC•••НОOC-SalA and -(Н)ОGC•••НОOC-SalA. Hydrophobic contacts of GC with SalA molecules are possible.

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Molecular Complexes of Monoammonium Glycyrrhizinate with Alphahederin and Hederasaponin C

Cited by 7 publications

References 10 publications

Molecular complexes of triterpene glycosides with 5-fluorouracil sodium salt: spectral characterization and cytotoxic activity

Molecular complexes of triterpene glycosides with 5-fluorouracil sodium salt: spectral characterization and cytotoxic activity

Molecular complexes of triterpenes and their glycosides with cyclodextrins: Recent advances and application prospects

Molecular complex of salicylic acid with glycyram

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