Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora’s lesion)

Nilsson, Malin A; Domanski, Henryk A.; Mertens, Fredrik; Mandahl, Nils

doi:10.1016/j.humpath.2004.02.008

Cited by 105 publications

(53 citation statements)

References 26 publications

(13 reference statements)

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“…It has been suggested t(1;17) represents a distinct translocation point in BPOP [6]. As only one lesion in our series had cytogenetic studies performed, we are not able to comment further on the significance of our findings regarding a specific genetic abnormality characteristic of BPOP, but the abnormal karyotype we identified has not been reported previously, indicating BPOP may not result from one pathogenetically significant aberration, as suggested by Nilsson et al [15], or t(1;17) is not the only distinct translocation point, as suggested by Endo et al [6].…”

Section: Resultscontrasting

confidence: 53%

“…This is supported by Zambrano et al [26], who identified an abnormal karyotype in one lesion (Ch 12 additional ring chromosomes, Ch 7 trisomy) and nonclonal abnormalities of chromosomes 2, 8, and 14 in another. The finding of a distinct t(1;17)(q32;q21) balanced translocation by Nilsson et al [15] and a t(1;17)(q42;p23) translocation by Endo et al [6] also supports this theory. Only one of our lesions was evaluated with genetic testing and this revealed karyotypic abnormalities at chromosomes 6 and 7.…”

Section: Resultsmentioning

confidence: 76%

“…It therefore was suggested by Zambrano et al [26] that BPOP could represent a neoplastic process. Subsequent work by Nilsson et al [15] and Endo et al [6] supports this and suggests t(1;17) represents a distinct translocation point unique to BPOP, thereby excluding the unitary hypothesis.…”

mentioning

confidence: 95%

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Bizarre Parosteal Osteochondromatous Proliferation: A Locally Aggressive Benign Tumor

Joseph

Ritchie

MacDuff

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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Background Bizarre parosteal osteochondromatous proliferation (BPOP) is a benign lesion of bone, and numerous questions remain unresolved regarding its etiology, diagnosis, and treatment. Questions/purposes We present the Scottish Bone Tumour Registry experience of this rare lesion. Patients and MethodsWe performed a retrospective analysis of the Scottish Bone Tumour Registry records. Histologic specimens were reexamined by a musculoskeletal pathologist. Radiographs were reevaluated by a musculoskeletal radiologist.Results From 1983 to 2009, 13 cases (13 patients; six male, seven female) were identified. Their ages ranged from 13 to 65 years. All patients presented with localized swelling. Pain was present in five. Antecedent trauma was present in two. Nine lesions affected the hand, three the foot, and one the tibial tuberosity. Twelve lesions were excised and one was curetted. There were seven recurrences of which six were excised. One lesion recurred a second time and was excised. There were no metastases. Radiographs showed densely mineralized lesions contiguous with an uninvolved cortex. Cortical breakthrough was present in one case and scalloping in another. Histologic analysis characteristically showed hypercellular cartilage with pleomorphism and calcification/ossification without atypia, bone undergoing maturation, and a spindle cell stroma. Conclusions BPOP is a rare benign lesion that probably is neoplastic, with no gender predilection, and affecting patients over a wide age range. Previously trauma was considered an etiologic factor, but this no longer seems to be the case. The rate of recurrence was 50%, which may indicate a more extensive resection is required for this locally aggressive lesion. No metastases were reported.

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Section: Resultscontrasting

confidence: 53%

Section: Resultsmentioning

confidence: 76%

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Bizarre Parosteal Osteochondromatous Proliferation: A Locally Aggressive Benign Tumor

Joseph

Ritchie

MacDuff

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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“…Zambrano et al suggested that BPOP could represent a neoplastic process, identifying karyotypic abnormalities of chromosomes 7 and 12 in one lesion, and nonclonal abnormalities of chromosomes 2, 8, and 14 in another [8]. Cytogenetic analyses by Nilsson et al and Endo et al revealed balanced chromosomal translocations at t(1;17) (q32;q21) and t(1;17) (q42;q23) respectively, raising the possibility that t(1;17) might represent a distinct translocation point that is unique to BPOP [9,10]. Subsequent studies, however, fail to confirm these findings, indicating that BPOP may not result from a single chromosomal aberration or distinct translocation point [3].…”

Section: Discussionmentioning

confidence: 97%

Painless hand mass

et al. 2016

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AnswerBizarre parosteal osteochondromatous proliferation (Nora lesion) of the metacarpal. DiscussionRadiograph (Fig. 1) and CT ( Fig. 2) images show a wellcorticated osseous lesion originating from the dorsomedial surface of the second metacarpal neck. There is a slight irregularity of the underlying cortex, but no periosteal reaction or bone destruction. Although no visible cleavage plane separates the lesion from the second metacarpal, the medullary space of the lesion is noncontiguous with that of the underlying bone, and it lacks characteristic orientation away from the joint space as is seen with an osteochondroma. Clinically, a firm, immobile, nontender mass was palpated in the second intermetacarpal space. The overlying skin was normal in appearance. Because the patient had a limited range of motion at the second and third carpometacarpal joints, surgical excision was performed. Histopathology demonstrates fragments of bone and cartilage with areas of endochondral ossification and surrounding bland fibroblastic proliferation. The interface between forming bone and cartilage has a characteristic purple-blue staining quality (Fig. 3).First described by Nora et al. in 1983 (described in A b r a m ov i c i a nd S t e i ne r [1 ] ), b i za rr e pa ro st e al osteochondromatous proliferation (BPOP), also referred to as a BNora lesion,^is a rare, benign, locally aggressive osteochondromatous exostosis composed of bone and cartilage in a fibrous myxoid cell stroma without cellular atypia. Histologically, BPOP is characterized by the presence of a hypercellular fibrocartilaginous cap containing large, bizarre binucleate chondrocytes, with admixed areas of endochondral ossification maturing to trabecular bone. Bony trabeculae are histologically immature, with high osteoblastic activity and irregular calcification.Bizarre parosteal osteochondromatous proliferation most commonly arise from the periosteum of the metacarpals and metatarsals, with the hand affected four times more commonly Fig. 1 Anteroposterior radiograph of the right second to fourth metacarpals and proximal phalanges The case presentation can be found at

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“…This maturation process has been hypothesized to represent a reparative etiology in the response to trauma [11,24,27], despite that the majority of patients described in case reports lack a traumatic history. More recently, some reports have suggested BPOP is a neoplastic process instead of a reparative one [7,12,17,22,26,28].…”

Section: Discussion and Treatmentmentioning

confidence: 99%

Asymptomatic Upper Arm Mass in a 37-year-old Woman

Rothenberg¹,

Zhang²,

Rosenberg³

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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A 37-year-old woman presented with a painless left upper extremity mass that she first noticed after a long strenuous workout 2 weeks before presentation. The patient denies any medical history, significant family history, and history of recent or remote trauma.On physical examination, there was a firm, fixed 3 cm 9 2 cm nontender mass palpable in the upper anterior aspect of the humerus. There were no overlying skin changes and she had full painless ROM of her shoulder and elbow.Plain radiographs (Fig. 1) and MRI ( Fig. 2) of the humerus were obtained.

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Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora’s lesion)

Cited by 105 publications

References 26 publications

Bizarre Parosteal Osteochondromatous Proliferation: A Locally Aggressive Benign Tumor

Bizarre Parosteal Osteochondromatous Proliferation: A Locally Aggressive Benign Tumor

Painless hand mass

Asymptomatic Upper Arm Mass in a 37-year-old Woman

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