Molecular-defined clonal evolution in patients with chronic myeloid leukemia who were exposed to ionizing radiation following the Chernobyl nuclear disaster

Ernst, Thomas; Rinke, Jenny; Hagen, Julia; Dmytrenko, I. V.; Hochhaus, Andreas; Dyagil, Iryna

doi:10.1038/s41375-019-0679-2

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…The time from the first mutation to the time of detection also increases with age (Figure 5c). The average time between the formation of the first Type 0 cell and the time of detection comes out to be marginally over 25 years, which agrees with clinical data from survivors of the Chernobyl nuclear disaster [Ernst et al, 2020].…”

Section: Retrospective Estimation Of Age Of Cancer Originsupporting

confidence: 81%

Studying the Age of Onset and Detection of Chronic Myeloid Leukemia Using a Three-Stage Stochastic Model

NAG,

BHAT,

CHAKRABARTY

2024

J. Biol. Syst.

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Chronic Myeloid Leukemia (CML) is a biphasic malignant clonal disorder that progresses, first with a chronic phase, where the cells have enhanced proliferation only, and then to a blast phase, where the cells have the ability of self-renewal. It is well recognized that the Philadelphia chromosome (which contains the BCR-ABL fusion gene) is the “hallmark of CML”. However, empirical studies have shown that the mere presence of BCR-ABL may not be a sufficient condition for the development of CML, and further modifications related to tumor suppressors may be necessary. Accordingly, we develop a three-mutation stochastic model of CML progression, with the three stages corresponding to the non-malignant cells with BCR-ABL presence, the malignant cells in the chronic phase, and the malignant cells in the blast phase. We demonstrate that the model predictions agree with age incidence data from the United States. Finally, we develop a framework for the retrospective estimation of the time of onset of malignancy, from the time of detection of the cancer.

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Section: Retrospective Estimation Of Age Of Cancer Originsupporting

confidence: 81%

Studying the Age of Onset and Detection of Chronic Myeloid Leukemia Using a Three-Stage Stochastic Model

NAG,

BHAT,

CHAKRABARTY

2024

J. Biol. Syst.

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“…Ten of 10 CML cases among Chernobyl accident cleanup workers arose after long delays [ 15 ]. As they were all young when exposed, the delays could reflect 20–30 years being needed to reach ages at which CML is more common.…”

Section: To the Editormentioning

confidence: 99%

What do atomic bomb survivors teach us about therapy-free remission in people with chronic myeloid leukaemia?

Radivoyevitch,

Gale,

Kalaycio

2023

Leukemia

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“…Notably, the global concern regarding nuclear waste leakage was kindled by the Fukushima accident in 2011 [6]. Further, the Chernobyl disaster in Ukraine occurred in 1986 wherein iodine radioisotopes were a major component of the radioactive contamination [7]. Moreover, the continuous operation of nuclear power plants can produce and introduce trace amounts of radioiodine into the environment [8].…”

Section: Introductionmentioning

confidence: 99%

Removal of Radioactive Iodine Using Silver/Iron Oxide Composite Nanoadsorbents

et al. 2021

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Efficient and cost-effective removal of radioactive iodine (radioiodine) from radioactive contaminated water has become a crucial task, following nuclear power plant disasters. Several materials for removing radioiodine have been reported in the literature. However, most of these materials exhibit some limitations, such as high production cost, slow adsorption kinetics, and poor adsorption capacity. Herein, we present silver/iron oxide nanocomposites (Ag/Fe3O4) for the efficient and specific removal of iodine anions from contaminated water. The Ag/Fe3O4 were synthesized using a modified method and characterized via scanning electron microscopy, transmission electron microscopy, and X-ray diffraction analyses. This adsorbent showed a high adsorption capacity for iodine anions (847 mg/g of the adsorbent) in pure water. Next, Ag/Fe3O4 was applied to the removal of radioiodine, and high removal efficiencies were observed in water. In addition, its desalination capacity was retained in the presence of competitive ions and varied pH. After the adsorption process, Ag/Fe3O4 was easily removed from the water by applying an external magnetic field. Moreover, the same operation can be repeated several times without a significant decrease in the performance of Ag/Fe3O4. Therefore, it is expected that the findings presented in this study will offer a new method for desalinating radioiodine in various aqueous media.

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Molecular-defined clonal evolution in patients with chronic myeloid leukemia who were exposed to ionizing radiation following the Chernobyl nuclear disaster

Cited by 5 publications

References 14 publications

Studying the Age of Onset and Detection of Chronic Myeloid Leukemia Using a Three-Stage Stochastic Model

Studying the Age of Onset and Detection of Chronic Myeloid Leukemia Using a Three-Stage Stochastic Model

What do atomic bomb survivors teach us about therapy-free remission in people with chronic myeloid leukaemia?

Removal of Radioactive Iodine Using Silver/Iron Oxide Composite Nanoadsorbents

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