Molecular detection and prevalence of SARS-CoV-2 during the early outbreak in Southern Bangladesh

Rana, Eaftekhar Ahmed; Chowdhury, Nahida Sarwer; Islam, M. S.; Ara, Jahan; Nasrin, Syeda S.; Dutta, Pronesh; Bristi, Sabiha Zarin Tasnim; Nizami, Tanvir Ahmad; Chakraborty, Prashanta; Siddiki, Amam Zonaed

doi:10.14202/ijoh.2020.153-159

Cited by 7 publications

(10 citation statements)

References 35 publications

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“…Owing to the lower population density of the environment, the COVID-19 lifestyle impact is comparatively low in rural areas. Several studies have established same kind of outcome among the infected individuals living in urban and rural areas which is in harmony with our findings 33 , 34 , 35 .…”

Section: Discussionsupporting

confidence: 93%

SARS-CoV-2 molecular identification and clinical data analysis of associated risk factors from a COVID-19 testing laboratory of a coastal region in Bangladesh

Ali¹,

Chowdhury²,

Mas-ud³

et al. 2021

Heliyon

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Background and Aim Outbreak of COVID-19 seems to have exacerbated across the globe, including Bangladesh. Scientific literature on the clinical data record of COVID-19 patients in Bangladesh is inadequate. Our study analyzes the clinical data of COVID-19 positive patients based on molecular identification and risk factor correlated with three variables (age, sex, residence) and COVID-19 prevalence in the four districts of Chattogram Division (Noakhali, Feni, Lakshmipur and Chandpur) with an aim to understand the trajectory of this pandemic in Chattogram, Southern Bangladesh. Methods A cross-sectional study is conducted in the context of RT-PCR-based COVID-19 positive 5,589 individuals diagnosed with SARS-CoV-2 infection from the COVID-19 testing laboratory, Abdul Malek Ukil Medical College, Noakhali-3800, Bangladesh. For molecular confirmation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), standard diagnostic protocols through real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) were conducted. Different patient demographics were analyzed using SPSS version 22 for exploring the relationship of three factors – age, sex, and residence with a cumulative number of COVID-19 positive cases and prevalence of COVID-19 in four districts in Chattogram division. The data was recorded between May to July, 2020. Results Among the three parameters, the present study revealed that 20-40 cohort had the highest incidence of infection rate (51.80%, n=2895) among the different age groups. Among the infected individuals, 56.8% (n=3177) were male and 43.2% (n=2412) were female, denoting males being the most susceptible to this disease. Urban residents (52.7%, n=2948) were more vulnerable to SARS-CoV-2 infection than those residing in rural areas (47.3%, n=2641). The prevalence of COVID-19 positive cases among the four districts was recorded highest in the Noakhali district with 36.8% (n=2057), followed by the Feni, Lakshmipur and Chandpur districts with 25.9% (n=1448), 20.8% (n=1163) and 16.5% (n=921), respectively. Conclusions This study presents a statistical correlation of certain factors linked to Bangladesh with confirmed COVID-19 patients, which will enable health practitioners and policy makers to take proactive steps to control and mitigate disease transmission.

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Section: Discussionsupporting

confidence: 93%

SARS-CoV-2 molecular identification and clinical data analysis of associated risk factors from a COVID-19 testing laboratory of a coastal region in Bangladesh

Ali¹,

Chowdhury²,

Mas-ud³

et al. 2021

Heliyon

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“…The present study reveals the severity of single dose Oxford-AstraZeneca vaccinated people infected with SARS CoV-2 in the Southeast part of Bangladesh. The overall prevalence of positive COVID-19 individuals was 28.51% which is almost similar to 29.76% prevalence, reported in early outbreak in the same study region(Rana et al, 2020). The prevalence of 1st dose vaccinated (Oxfordintervals(Keehner et al, 2021).…”

supporting

confidence: 81%

“…The present study was conveyed in the greater Chattogram division of Bangladesh which comprises 11 districts (BNP 2021/13). Geographically, it is located in the southeast part of Bangladesh and well recognized as one of the major seaports of the country (Rana et al, 2020).…”

Section: Study Areamentioning

confidence: 99%

Severity assessment of single dose Oxford–AstraZeneca vaccinated individuals infected with SARS CoV-2 in the Southeast Bangladesh

Rana

Dutta

Islam

et al. 2021

Preprint

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The present global endeavor to uncover the most effective vaccines against severe acute respiratory syndrome coronavirus (SARS-CoV-2) that can tremendously prevent transmission, infection and significantly reduce public health risk. COVID-19 vaccination program is underway in different parts of the world including Bangladesh but till to date there is no available health data revealed among the vaccinated peoples. We conducted a cross-sectional study from February 15 to April 15, 2021 to assess the health status of 1st dose Oxford-AstraZeneca vaccinated individuals infected with SARS CoV-2. Standard virological method, real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) was performed to detect SARS-CoV-2 and the different health parameters from vaccinated individuals were collected through direct mobile phone contact using pre-structured questionnaires. A total of 6146 suspected samples were tested and 1752 were found positive for SARS-CoV-2, of them 200 individuals were identified who received 1st dose of COVID-19 vaccine. Within the test period, majority of male (65.6%) and female (34.4%) carried moderate numbers of viruses which comprise between 30.01-35 cyclic threshold (ct) values. Among the vaccinated individuals, 165 (82.5%; 95% CI: 76.51 - 87.5) persons were not hospitalized and 177 (88.5%; 95% CI: 83.24 - 92.57) did not show any respiratory difficulties. Only a few (16) (8%; 95% CI: 4.64 - 12.67) of COVID-19 positive patients needed extra oxygen support and 199 (99.5%; 95% CI: 97.25 - 99.99) individuals did not require any intensive care unit (ICU) interference. Overall, oxygen saturation was recorded around 96.8% and respiratory difficulties did not extend more than 5 days, irrespective of age and sex during the infection period. Within the vaccinated COVID-19 positive individuals 113 (56.5%; 95% CI: 49.33 - 63.48) and 111(55.5%; 95% CI: 48.32 - 62.51) persons have normal physiological taste and smell. However, we have found a larger proportion of vaccinated persons (129) (64.5%; 95% CI: 57.44 - 71.12) carrying different comorbidity, among them high blood pressure 36 (27.9%; 95% CI, 20.37 - 36.48) and diabetes 32 (24.8%; 95% CI: 17.63 - 33.18) were found more prevalent. Moreover, the significant finding of the present study was 199 (99.5%; 95% CI: 97.25 - 99.99) vaccinated individuals survived with good health conditions and became negative in RT-qPCR. The authors suggest that health risk assessment among the COVID-19 vaccinated persons when infected with SARS-CoV-2 is crucial and time demanding task for the whole world. However, the present study illustrates that the administration of the 1st dose Oxford-AstraZeneca vaccine significantly reduces health risk during the COVID-19 infection period.

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“…As reported by the WHO, 8093 people from 26 countries were infected with SARS-CoV with a mortality rate of 9% in 2003. Besides other coronaviruses, SARS-CoV-2 shows a fast transmissibility rate and a higher mortality rate due to comorbidity [16]. According to a WHO report, a much higher degree of transmission is observed in SARS-CoV-2, where more than 138.68 million people became infected across 223 countries, with a mortality rate 2.15% so far until the preparation of this manuscript.…”

Section: Introductionmentioning

confidence: 94%

Coronavirus disease 2019 and its potential animal reservoirs: A review

et al. 2021

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In the 21st century, the world has been plagued by coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a virus of the family Coronaviridae epidemiologically suspected to be linked to a wet market in Wuhan, China. The involvement of wildlife and wet markets with the previous outbreaks simultaneously has been brought into sharp focus. Although scientists are yet to ascertain the host range and zoonotic potential of SARS-CoV-2 rigorously, information about its two ancestors, SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), is a footprint for research on COVID-19. A 96% genetic similarity with bat coronaviruses and SARS-CoV-2 indicates that the bat might be a potential reservoir of SARS-CoV-2 just like SARS-CoV and MERS-CoV, where civets and dromedary camels are considered the potential intermediate host, respectively. Perceiving the genetic similarity between pangolin coronavirus and SARS-CoV-2, many scientists also have given the scheme that the pangolin might be the intermediate host. The involvement of SARS-CoV-2 with other animals, such as mink, snake, and turtle has also been highlighted in different research articles based on the interaction between the key amino acids of S protein in the receptor-binding domain and angiotensin-converting enzyme II (ACE2). This study highlights the potential animal reservoirs of SARS-CoV-2 and the role of wildlife in the COVID-19 pandemic. Although different causes, such as recurring viral genome recombination, wide genetic assortment, and irksome food habits, have been blamed for this emergence, basic research studies and literature reviews indicate an enormous consortium between humans and animals for the COVID-19 pandemic.

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Molecular detection and prevalence of SARS-CoV-2 during the early outbreak in Southern Bangladesh

Cited by 7 publications

References 35 publications

SARS-CoV-2 molecular identification and clinical data analysis of associated risk factors from a COVID-19 testing laboratory of a coastal region in Bangladesh

SARS-CoV-2 molecular identification and clinical data analysis of associated risk factors from a COVID-19 testing laboratory of a coastal region in Bangladesh

Severity assessment of single dose Oxford–AstraZeneca vaccinated individuals infected with SARS CoV-2 in the Southeast Bangladesh

Coronavirus disease 2019 and its potential animal reservoirs: A review

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