Molecular determinants of cranial neural crest-derived odontogenic ectomesenchyme during dentinogenesis

Abstract

Positional information on tooth morphogenesis is investigated by the identification of when and where phenotypic markers are expressed during odontogenesis. This temporal and positional information is correlated with the instructive and permissive signaling required for both dentinogenesis and amelogenesis. Of particular interest is the establishment of a map for the cranial neural crest-derived dental papilla ectomesenchyme and the odontoblast cell lineages. The expression of ectomesenchymederived cytotactin, dentin phosphoprotein, and epithelial-derived enamel proteins was studied in mice using embryonic, fetal, and postnatal mandibular first molar tooth organ development. This review summarizes the observations in the context of instructive epithelial-mesenchymal interactions and suggests that amelogenesis imperfecta and dentinogenesis imperfecta may in part be explained by alterations in these differentiation markers. Recombinant DNA methods should facilitate future investigations of these inherited dental disorders.

Characterization of optical properties of acrylate based adhesives exposed to different temperature conditions

“…On the other hand, the dental papilla, which gives rise to the pulp, was Xgal‐positive (Fig. 1E), in agreement with its neural crest origin (Slavkin et al,1988). All of the mesenchyme surrounding the tooth bud, some of which will contribute to the periodontium, was also Xgal‐positive (Fig.…”

Taurodontism: An anomaly of teeth reflecting disruptive developmental homeostasis

“…Here they initiate differentiation of odontoblasts which form the dentin of the root. Thus, normal tooth development requires not only inducible, biochemically competent cellular elements [Slavkin et al, 19881, but also, by analogy from abnormal tooth formation [Sauk et al, 19721, the proper spatial relationship of the cellular elements [Slavkin et al, 1988;Sauk et al, 19721).…”

Nestin expression in odontoblasts and odontogenic ectomesenchymal tissue of odontogenic tumours

“…[18][19][20] However, nestin associated with human odontogenic ectomesenchyme is not expressed throughout life, but rather during limited periods such as odontogenesis and repair of dentine. 13 15 21 In addition, our characterisation of odontogenic ectomesenchymal tissues indicated no differentiation towards muscle and nervous tissues, and immunohistochemical examination revealed intriguing localisation and distribution of nestin in various odontogenic tumours.…”