Molecular displaying of differential immunoresponse to various infections of amniotic epithelia

Abstract

This study proved that HAECs uses alternative gene expression profiles for fighting different pathogens.

Potential Activity of Some Essential Oils and Human Amniotic Membrane against Malassezia furfur and Staphylococcus aureus Isolated from Pityriasis Versicolor Patients

“…Antimicrobial activity of vital HAM was proved by Niknejad et al (2008) and Chopra & Thomas (2013), which is due to secretion of constitutive expression of low molecular weight antimicrobial peptides as definsins, which are considered as broad spectrum antibiotics, these released peptides led to killing wide range of microbial cells including Gram-positive and Gram-negative bacteria and C. albicans as a potential pathogenic fungus (Nemr et al, 2017). Also, many of clinical trails using amniotic membrane as a biological bandage were published for curing some of skin disorders and ulcers.…”

Crescentic Glomerulonephritis: Pathogenesis and Therapeutic Potential of Human Amniotic Stem Cells

“…Human β-defensins, small proteins which promote microbial death, are primarily expressed by epithelial and immune cells at mucosal surfaces (Dorin et al, 2015). These natural antimicrobial molecules have been reported to be secreted by human placenta cells including hAECs and by the fetal membrane during human pregnancy in order to protect the uterus from infection (King et al, 2007;Nemr et al, 2017). hAECs also produce type I interferons (IFNs) in response to viruses in vitro (Uchide et al, 2002;Nemr et al, 2017).…”

“…These natural antimicrobial molecules have been reported to be secreted by human placenta cells including hAECs and by the fetal membrane during human pregnancy in order to protect the uterus from infection (King et al, 2007;Nemr et al, 2017). hAECs also produce type I interferons (IFNs) in response to viruses in vitro (Uchide et al, 2002;Nemr et al, 2017). This group of proteins, which is made up mainly of IFNα and IFNβ, initiate intracellular anti-microbial systems and influence innate and adaptive immune responses (Ivashkiv and Donlin, 2014).…”

Emerging Cellular Therapies for Anti-myeloperoxidase Vasculitis and Other Autoimmune Diseases

“…Unlike the current AAV treatments, hAECs are unlikely to cause major side effects because they have anti-infection and anti-cancer properties. They produce various anti-microbial mediators including β-defensins and type I interferons in response to bacteria and viruses in vitro ( 105 , 106 ). They inhibit cancers directly by inducing apoptosis of malignant cells and indirectly by enhancing anti-tumor immunity in vivo ( 107 , 108 ).…”