Molecular docking and in vitro anticancer studies of silver(I)-N-heterocyclic carbene complexes

Akkoç, Mitat; Khan, Siraj; Yüce, Hande; Türkmen, Neşe Başak; Yaşar, Şeyma; Yaşar, Sedat; Özdemır, İsmaıl

doi:10.1016/j.heliyon.2022.e10133

Cited by 14 publications

(2 citation statements)

References 71 publications

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“…Ag(I) complexes have also been studied for their potential use as anticancer agents due to their unique properties and interaction with cellular components, such as DNA and proteins, leading to disruption of essential biological processes [237]. For example, Ag(I) complexes with N-heterocyclic carbene ligands have been studied for their anticancer activities against a range of cancer cell lines, including lung cancer [238].…”

Section: Silver (Ag)mentioning

confidence: 99%

The Lung Microbiome in COPD and Lung Cancer: Exploring the Potential of Metal-Based Drugs

O’Shaughnessy,

Sheils,

Baird

2023

IJMS

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Chronic obstructive pulmonary disease (COPD) and lung cancer 17 are two of the most prevalent and debilitating respiratory diseases worldwide, both associated with high morbidity and mortality rates. As major global health concerns, they impose a substantial burden on patients, healthcare systems, and society at large. Despite their distinct aetiologies, lung cancer and COPD share common risk factors, clinical features, and pathological pathways, which have spurred increasing research interest in their co-occurrence. One area of particular interest is the role of the lung microbiome in the development and progression of these diseases, including the transition from COPD to lung cancer. Exploring novel therapeutic strategies, such as metal-based drugs, offers a potential avenue for targeting the microbiome in these diseases to improve patient outcomes. This review aims to provide an overview of the current understanding of the lung microbiome, with a particular emphasis on COPD and lung cancer, and to discuss the potential of metal-based drugs as a therapeutic strategy for these conditions, specifically concerning targeting the microbiome.

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Section: Silver (Ag)mentioning

confidence: 99%

The Lung Microbiome in COPD and Lung Cancer: Exploring the Potential of Metal-Based Drugs

O’Shaughnessy,

Sheils,

Baird

2023

IJMS

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“…The possibility to modulate the coordination sphere of the silver(I) cation has allowed, in particular, the development of efficient silver complexes for medicinal applications, notably as antibacterial, antifungal, or anticancer agents [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. In recent years, there has been growing interest in organic silver complexes as promising anticancer agents with efficacious activity against various cancer cell lines [ 42 , 43 , 44 ]. These complexes, which exhibit low toxicity for humans [ 45 ] and have long been used as antimicrobial drugs, are potential candidates to replace platinum-based anticancer drugs such as cisplatin ( cis -diaminodichloroplatine(II) [Pt(NH 3 ) 2 Cl 2 ]) [ 46 ], which, despite their success, have drug resistance, undesirable side-effects such as gastrointestinal disorders, bleeding, allergic reactions, or a decrease in immunity, and are effective against only a few types of cancer [ 47 ].…”

Section: Introductionmentioning

confidence: 99%

Silver(I) Complexes Based on Oxadiazole-Functionalized α-Aminophosphonate: Synthesis, Structural Study, and Biological Activities

et al. 2022

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Two silver(I) complexes, bis{diethyl[(5-phenyl-1,3,4-oxadiazol-2-yl-κN3:κN4-amino) (4-trifluoromethylphenyl)methyl]phosphonate-(tetrafluoroborato-κF)}-di-silver(I) and tetrakis-{diethyl[(5-phenyl-1,3,4-oxadiazol-2-yl-κN3-amino)(4-trifluoromethylphenyl)methyl]phosphonate} silver(I) tetrafluoroborate, were prepared starting from the diethyl[(5-phenyl-1,3,4-oxadiazol-2-yl-amino)(4-trifluoromethylphenyl)methyl]phosphonate (1) ligand and AgBF4 salt in Ag/ligand ratios of 1/1 and 1/4, respectively. The structure, stoichiometry, and geometry of the silver complexes were fully characterized by elemental analyses, infrared, single-crystal X-ray diffraction studies, multinuclear NMR, and mass spectroscopies. The binuclear complex ([Ag2(1)2(BF4)2]; 2) crystallizes in the monoclinic asymmetric space group P21/c and contains two silver atoms adopting a {AgN2F} planar trigonal geometry, which are simultaneously bridged by two oxadiazole rings of two ligands, while the mononuclear complex ([Ag(1)4]BF4; 3) crystallizes in the non-usual cubic space group Fd-3c in which the silver atom binds to four distinct electronically enriched nitrogen atoms of the oxadiazole ring, in a slightly distorted {AgN4} tetrahedral geometry. The α-aminophosphonate and the monomeric silver complex were evaluated in vitro against MCF-7 and PANC-1 cell lines. The silver complex is promising as a drug candidate for breast cancer and the pancreatic duct with half-maximal inhibitory concentration (IC50) values of 8.3 ± 1.0 and 14.4 ± 0.6 μM, respectively. Additionally, the interactions of the ligand and the mononuclear complex with Vascular Endothelial Growth Factor Receptor-2 and DNA were evaluated by molecular docking methods.

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Water-soluble N-heterocyclic carbene precursors bearing benzimidazole core: synthesis, characterization, in vitro antioxidant and anticancer studies

2023

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Molecular docking and in vitro anticancer studies of silver(I)-N-heterocyclic carbene complexes

Cited by 14 publications

References 71 publications

The Lung Microbiome in COPD and Lung Cancer: Exploring the Potential of Metal-Based Drugs

The Lung Microbiome in COPD and Lung Cancer: Exploring the Potential of Metal-Based Drugs

Silver(I) Complexes Based on Oxadiazole-Functionalized α-Aminophosphonate: Synthesis, Structural Study, and Biological Activities

Water-soluble N-heterocyclic carbene precursors bearing benzimidazole core: synthesis, characterization, in vitro antioxidant and anticancer studies

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