Molecular encapsulation of berberine by a modified β-cyclodextrin and binding of host: guest complex to G-quadruplex DNA

Suganthi, Soundrapandian; Ramasamy, Sivaraj; Enoch, Israel V.M.V.

doi:10.1080/15257770.2019.1618469

Cited by 20 publications

(5 citation statements)

References 40 publications

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“…Lots of high-quality research have been done on the interaction of various complexes with DNA and BSA. This can show the broad scope of this type of research (Natesan et al, 2014;Chandrasekaran et al, 2015a;Chandrasekaran et al, 2015b;Suganthi et al, 2019). Lanthanides have many cellular applications due to their resistance to oxidation and reduction.…”

Section: Introductionmentioning

confidence: 79%

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Raeisi Vanani,

Asadpour,

Aramesh-Boroujeni

et al. 2023

Front. Chem.

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To learn more about the chemotherapeutic and pharmacokinetic properties of a neodymium complex containing 1,10-phenanthroline (dafone), In vitro binding was investigated with bovine serum albumin and fish-salmon DNA, using a variety of molecular modeling research and biophysical approaches. A variety of spectroscopic techniques including fluorescence and absorption were used to investigate the interplay between DNA/BSA and the neodymium complex. The findings revealed that the Nd complex had a high affinity for BSA and DNA interplays through van der Waals powers. In addition, the binding of the Nd complex to FS-DNA mainly in the groove binding mode clearly reflects with iodide quenching studies, ethidium bromide (EtBr) exclusion assay, ionic strength effect, and viscosity studies. It was observed that the Nd complex binds to FS-DNA through a minor groove with 3.81 × 105 (M−1). Also, Kb for BSA at 298 K was 5.19×105 (M−1), indicating a relatively high affinity of the Nd complex for DNA and BSA. In addition, a competitive study of a docking investigation revealed that the neodymium complex interacts at BSA site III. The results obtained from the binding calculations are well consistent with the experimental findings. Also, cytotoxicity studies of Nd complex were performed in MCF-7 and A-549 cell lines and the results show that this new complex has a selective inhibitory effect on the growth of various cancer cells.

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Section: Introductionmentioning

confidence: 79%

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Raeisi Vanani,

Asadpour,

Aramesh-Boroujeni

et al. 2023

Front. Chem.

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“…It is worth mentioning that berberine is a compound with proven ability to bind to G-quadruplexes. Currently, berberine has also been proven to increase the affinity of iminopyrenyl-β-cyclodextrin for the DNA duplex, which may be important in terms of developing new therapeutic formulations [109].…”

Section: Supportive Action Of Berberine-sensitization and Drug Resistancementioning

confidence: 99%

Biological Activity of Berberine—A Summary Update

Och

Podgórski

Nowak

2020

Toxins

137

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Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong biological and pharmacological activity. Currently, berberine is receiving considerable interest due to its anticancer activity based on many biochemical pathways, especially its proapoptotic and anti-inflammatory activity. Therefore, the growing number of papers on berberine demands summarizing the knowledge and research trends. The efficacy of berberine in breast and colon cancers seems to be the most promising aspect. Many papers focus on novel therapeutic strategies based on new formulations or search for new active derivatives. The activity of berberine is very important as regards sensitization and support of anticancer therapy in combination with well-known but in some cases inefficient therapeutics. Currently, the compound is being assessed in many important clinical trials and is one of the most promising and intensively examined natural agents.

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“…The G-quadruplex provides a good substrate for ligand binding via π-π stacking. Several attach to the G-quadruplex by exploiting the groove produced by the backbone network, which primarily have included the terminal G-tetrads, the intermediate G-tetrads, the loops/backbones/grooves, and the middle channels [ 32 , 33 ]. Planar heterocyclic ligands engage with G-quadruplexes mostly by π-π mounting on the terminal G-tetrads and less often by intercalating into the G-tetrads [ 34 ].…”

Section: G-quadruplex–ligand: Mode Of Interactionmentioning

confidence: 99%

Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon

Bag¹,

Burman²,

Bhowmik³

2023

Heliyon

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Molecular encapsulation of berberine by a modified β-cyclodextrin and binding of host: guest complex to G-quadruplex DNA

Cited by 20 publications

References 40 publications

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Biological Activity of Berberine—A Summary Update

Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon

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