Molecular Engineering of Guanine-Rich Sequences: Z-DNA, DNA Triplexes, and G-Quadruplexes

Mechanochemical Complexation of Diethyl N,N´-[1,3-(2-methyl)phenyl]dioxalamate and Resorcinol: Conformational Twist and X-Ray Helical Supramolecular Architecture

“…Hydrogen bonding is the most important noncovalent interaction used in the design of supramolecular helices, allowing the development of supramolecular systems such as helical polymers [2], DNA assemblies [3] and helicenes [4,5].…”

Voltammetry and molecular assembly of G-quadruplex DNAzyme on single-crystal Au(111)-electrode surfaces – hemin as an electrochemical intercalator

“…Electronic conductivity of "non-canonical" DNA forms, quadruplexes in particular have also been addressed, but such reports have only begun to appear much more recently [27][28][29][30][31][32][33] , and with little if any direct approach to interfacial ; (c) surface immobilized G-quadruplexes finally offer perspectives for ultra-sensitive detection of metal ions [40][41][42] , complex biomolecules such as peptides [23][24][25][26][27][28][29][30] , and perhaps other analytes.…”

“…The G-qs's resemble the telomer ends in the chromosomes [23][24][25][26][27][28] . Their natural biological functions are largely unknown, but G-qs peptide binding and recognition has attracted interest in peptide sensing, therapy and other biotechnology [26][27][28] .…”

Towards Metal-Mediated G-Quartet Analogues: 1,2,4-Triazole Nucleotides

“…In this regard chemical modifications of G-rich sequences can be used to direct the formation of G-quadruplex configurations that can find use in various applications. [7,8] Several groups have made use of metal-coordinating nucleotides in duplex-forming sections of DNA to direct G-quadruplex assembly. [9][10][11] We, and others, proposed that a metal-coordinating quartet could function as an orthogonal partner to the standard G-quartet that can guide G-quadruplex formation.…”