Molecular epidemiological studies of human herpesvirus 6 in families

Mukai, T.; Yamamoto, Takeshi; Kondo, Toshio; Kondo, Kazuhiro; Okuno, Toshiomi; Kosuge, Haruhiko; Yamanishi, Koichi

doi:10.1002/jmv.1890420303

Cited by 59 publications

(29 citation statements)

References 24 publications

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“…The shedding of HHV-6 in the secretions of asymptomatic caretakers is thought to be a major route of transmission, while contact with infants is another possible route Mukai et al, 1994;Tanaka-Taya et al, 1996]. It has also been reported that HHV-6 may be transmitted during the intrauterine or perinatal period [Okuno et al, 1995], although transmission through breast-feeding has been disproved [Kusuhara et al, 1997;Fujisaki et al, 1998].…”

Section: Introductionmentioning

confidence: 99%

Human herpesvirus 6 (HHV‐6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV‐6 DNA

Tanaka‐Taya

Sashihara

Kurahashi

et al. 2004

Journal of Medical Virology

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204

172

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We obtained 7,566 peripheral blood mononuclear cell (PBMC) samples from 2,332 individuals and screened them for human herpesvirus infection. We identified five individuals who persistently harbored high copy numbers of human herpesvirus 6 (HHV-6) DNA in their PBMCs. HHV-6 DNA was also detected in other somatic tissues of these individuals. Five additional cases were identified among their family members. For two of these families, chromosomally integrated HHV-6 DNA (CIHHV-6) was detected in the PBMCs by fluorescence in situ hybridization. The prevalence of CIHHV-6 among all the subjects was 0.21%. The HHV-6 DNA was variant B in four families and variant A in one family. Antibodies to immediate early antigen and glycoprotein B were detected in 57 and 14% of individuals with CIHHV-6 and in 0 and 60% of healthy volunteers without CIHHV-6, respectively. HHV-6 could not be isolated from PBMCs with CIHHV-6. These cases shared no clinical features, and included three healthy individuals. Our data suggest that CIHHV-6 is rare but detectable in the general population and that hereditary transmission is one of the routes of HHV-6 transmission.

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Section: Introductionmentioning

confidence: 99%

Human herpesvirus 6 (HHV‐6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV‐6 DNA

Tanaka‐Taya

Sashihara

Kurahashi

et al. 2004

Journal of Medical Virology

Self Cite

204

172

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“…HHV‐7 uses the CD4 receptor to infect and establish latency in T lymphocytes; active replication occurs in salivary glands . The principal mode of transmission for both viruses is horizontal via saliva of siblings or adult family members . Vertical spread of HHV‐6 can occur as well, either transplacentally or through inheritance from one or both parents, as HHV‐6 is integrated into the genome of 0.2–3% of the population .…”

Section: Pathogenesis and Transmissionmentioning

confidence: 99%

Roseola infantum and its causal human herpesviruses

2014

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Roseola infantum, also known as exanthem subitum or sixth disease, is a generally benign febrile exanthem of infancy. It has a characteristic clinical course of high fever followed by the appearance of an exanthem upon defervescence. Febrile seizures are a frequent complication. Roseola is caused by infection with human herpesviruses 6 or 7 (HHV-6/7), which are acquired at a young age. Diagnosis is made by serology or by virus detection in body fluids and tissues. Treatment of roseola is supportive; recovery is usually complete with no significant sequelae. However, HHV-6/7 can reactivate in immunocompetent as well as immunocompromised individuals with severe systemic consequence.

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“…HHV-6 is one of the most widespread herpesviruses, infecting the human population with a prevalence approaching 100%. The most probable route for transmission is through saliva, either from mother to child or between children [Mukai et al 1994]. Two types (A and B) can be identified; no diseases have clearly been linked to HHV-6A infection, whereas HHV-6B is responsible for exanthema subitum.…”

Section: Human Herpesvirusmentioning

confidence: 99%

Herpesvirus infections of the central nervous system in immunocompromised patients

Meyding‐Lamadé

Strank

2012

Ther Adv Neurol Disord

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Human herpesviruses may cause infections of the central nervous system during primary infection or following reactivation from a latent state. Especially in immunosuppressed patients the infection can take a life-threatening course, and therefore early diagnosis of herpesvirus-associated neurological diseases should have high priority. Clinical presentation in these patients is usually without typical features, making diagnosis even more challenging. Therefore general broad testing for different herpesviruses in cerebrospinal fluid samples is highly recommended. In addition, determination of the virus DNA level in the cerebrospinal fluid by quantitative assays seems to be of high importance to determine prognosis. Moreover, it might help to differentiate between specific virus-associated disease and unspecific presence of virus in the cerebrospinal fluid, especially in immunocompromised patients. Polymerase chain reaction analysis of cerebrospinal fluid has revolutionized the diagnosis of nervous system viral infections, particularly those caused by human herpesviruses. This review summarizes the role human herpesviruses play in central nervous system infections in immunocompromised patients, with a focus on the clinical manifestation of encephalitis.

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Molecular epidemiological studies of human herpesvirus 6 in families

Cited by 59 publications

References 24 publications

Human herpesvirus 6 (HHV‐6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV‐6 DNA

Human herpesvirus 6 (HHV‐6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV‐6 DNA

Roseola infantum and its causal human herpesviruses

Herpesvirus infections of the central nervous system in immunocompromised patients

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