Roseola infantum and its causal human herpesviruses

Stone, Rivka C.; Micali, Giuseppe; Schwartz, Robert A.

doi:10.1111/ijd.12310

Cited by 36 publications

(33 citation statements)

References 56 publications

(120 reference statements)

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“…These include CMV syndrome, graft infection, colitis, retinitis, pneumonitis and predisposition to opportunistic infections (8, 9). HHV-6 is the causative agent of roseola infantum , and encephalitis in rare cases (10). The γ-herpesviruses are oncogenic, since chronic EBV is linked to nasopharyngeal carcinoma and Hodgkin and non-Hodgkin lymphomas (Burkitt's lymphoma among others), besides infectious mononucleosis upon primary infection.…”

Section: Introductionmentioning

confidence: 99%

Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase

Topalis¹,

Gillemot²,

Snoeck³

et al. 2016

Nucleic Acids Res

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Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing concern in immunocompromised patients. Herpesvirus DNA polymerase (DNApol) is currently the target of nucleos(t)ide analogue-based therapy. Mutations in DNApol that confer resistance arose in immunocompromised patients infected with herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV), and to lesser extent in herpes simplex virus 2 (HSV-2), varicella zoster virus (VZV) and human herpesvirus 6 (HHV-6). In this review, we present distinct drug-resistant mutational profiles of herpesvirus DNApol. The impact of specific DNApol amino acid changes on drug-resistance is discussed. The pattern of genetic variability related to drug-resistance differs among the herpesviruses. Two mutational profiles appeared: one favoring amino acid changes in the Palm and Finger domains of DNApol (in α-herpesviruses HSV-1, HSV-2 and VZV), and another with mutations preferentially in the 3′-5′ exonuclease domain (in β-herpesvirus HCMV and HHV-6). The mutational profile was also related to the class of compound to which drug-resistance emerged.

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Section: Introductionmentioning

confidence: 99%

Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase

Topalis¹,

Gillemot²,

Snoeck³

et al. 2016

Nucleic Acids Res

View full text Add to dashboard Cite

show abstract

“…HHV‐6B is highly seroprevalent, affecting nearly 100% of the population by age 3 and causes common childhood illness exanthem subitem. HHV‐6B was detected much more frequently in cerebrospinal fluid (CSF) than HHV‐6A . HHV‐7 establishes latent infections in CD4 + T cells and lytic infection in salivary gland epithelial cells .…”

Section: Epidemiological Evidence Indicates Herpesviruses Might Be Mamentioning

confidence: 99%

Herpesviral infections and antimicrobial protection for Alzheimer's disease: Implications for prevention and treatment

Qin

2019

Journal of Medical Virology

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Accumulating evidence suggests that infections by herpesviruses might be closely linked to Alzheimer's disease (AD). Pathological hallmarks of AD brains include senile plaques induced by amyloid β peptide (Aβ) in the extracellular space and intracellular neurofibrillary tangles (NFTs) consisting of phosphorylated tau protein. The prevailing hypothesis for the mechanism of AD is amyloid cascade reaction. Recent studies revealed that infections by herpesviruses induce the similar pathological hallmarks of AD, including Aβ production, phosphorylation of tau (P-tau), oxidative stress, neuroinflammation, etc. Aβ peptide is regarded as one of the antimicrobial peptides, which inhibits HSV-1 replication. In the elderly, reactivation of herpesviruses might act as an initiator for amyloid cascade reaction in vulnerable individuals, triggering the neurofibrillary formation of phosphorylated tau and inducing oxidative stress and neuroinflammation, which can further contribute to the accumulation of Aβ and P-tau by impairing mitochondria and autophagosome. Epidemiological studies have shown AD susceptibility genes, such as APOE-ε4 allele, are highly linked to infections by herpesviruses. Interestingly, anti-herpesviral therapy significantly reduced the risk of AD in a large population study. Given that herpesviruses are arguably the most prevalent opportunistic pathogens and often reactivate in the elderly, it is reasonable to argue reactivation of herpesviruses might be major culprits for initiating AD in individuals carrying AD susceptibility genes. In this review, we summarize epidemiological and molecular evidence that support for a hypothesis of herpesviral infections and antimicrobial protection in the development of AD, and discuss the implications for future prevention and treatment of the disease.

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“…Заболевание характерно для детей раннего возраста. Этиотропным фактором детской розеолы являются герпесвирусы 6 и 7 типов [5]. Частота выявления вируса герпеса 6 типа у заболевших младенцев варьирует от 10 до 40%, увеличивается с возрастом.…”

Section: результаты и их обсуждениеunclassified

Rare Forms of Exanthems in Pediatric Clinical Practice

2018

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The infant roseola, viral pemphigus, papular-hemorrhagic rash as a form of gloves and socks syndrome, and one-sided laterothoracic exanthema can be referred to the rare types of infectious rash in the pediatrician’s practice. These diseases, despite certain signs peculiar to everyone, are often not diagnosed during the initial admission to a pediatrician. The study describes the characteristics of each type of rash, the course of the disease, and discusses possible errors in the primary diagnosis of rare infectious rashes.

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Roseola infantum and its causal human herpesviruses

Cited by 36 publications

References 56 publications

Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase

Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase

Herpesviral infections and antimicrobial protection for Alzheimer's disease: Implications for prevention and treatment

Rare Forms of Exanthems in Pediatric Clinical Practice

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