Molecular epidemiology of HIV-1 in Madrid

Rojas, José M.; Dopazo, Joaquı́n; Nájera, Isabel; Sánchez-Palomino, Sonsoles; Olivares, Isabel; Martin, Maria Jesus; Bernal, A.; Sáiz, Alfredo García; Nájera, Rafael; López-Galı́ndez, Cecilio

doi:10.1016/0168-1702(94)90026-4

Virus Research

1994

DOI: 10.1016/0168-1702(94)90026-4

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Molecular epidemiology of HIV-1 in Madrid

José M. Rojas

Joaquı́n Dopazo²,

Isabel Nájera

et al.

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Cited by 17 publications

(1 citation statement)

References 30 publications

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“…Construction of phylogenetic trees from DNA sequences from isolates of HIV-1 has led to the recognition of over 15 subtypes (or clades), where each subtype is composed of a multitude of variants (or strains); isolates assigned to a particular subtype are considered to be more closely related to other isolates of the same subtype, though considerable variability exists among variants of a given subtype [Fisher et al 1988;Hu et al 1996;Kuiken et al 1993;Rojas et al 1994]. …”

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confidence: 99%

Designing HIV Vaccination Policies: Subtypes and Cross-Immunity

Porco¹,

Blower²

1998

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We developed and used mathematical models to assess vaccine programs for controlling two subtypes of HIV, both for developing countries where more than one subtype is present and for countries where only one subtype is present but other subtypes may invade. We began by formulating a model of the intrinsic transmission dynamics of the two HIV subtypes and then extended this model to include the effects of a prophylactic vaccine that provides a degree of protection against infection by one subtype and vaccine-induced cross-immunity against infection by the second subtype. Using these models, we assessed the potential impact of using a prophylactic vaccine when one subtype of HIV is endemic and a second subtype is introduced into the community. In each case, mass vaccination could result in one of four possible outcomes: (1) both subtypes are eradicated, (2) the endemic subtype persists and the invading subtype is eradicated, (3) the endemic subtype is eradicated and the invading subtype persists, or (4) both subtypes coexist.

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mentioning

confidence: 99%

Designing HIV Vaccination Policies: Subtypes and Cross-Immunity

Porco¹,

Blower²

1998

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Sequence analysis of HIV-1vif gene in Spanish isolates

Olivares¹,

Menéndez‐Arias

Rodríguez-Bernabé³

et al. 1995

Virus Genes

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We have determined the nucleotide sequence of the HIV-1 vif gene in viruses obtained from symptomatic patients of distinct risk groups in Madrid. The genetic diversity among the isolates was estimated in 4.6% (+/- 1.4 standard deviation), a similar value to that obtained for the gag gene 3.9% (+/- 0.8 standard deviation) and env 4.1% (+/- 1 standard deviation) (Rojas et al., Virus Res 31, 331-342, 1994). Amino acid sequence analysis revealed the presence of hypermutable residues at positions 101 and 167, close to antigenically relevant sequential epitopes (comprising amino acids 87-94 and 172-178). Phylogenetic analysis supports the existence of two virus lineages circulating preferentially within different risk groups.

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HIV vaccines: The effect of the mode of action on the coexistence of HIV subtypes

Porco¹,

Blower

2000

Mathematical Population Studies

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We analyze a mathematical model of the simultaneous transmission of two HIV subtypes and their control by vaccines. Two vaccines are analyzed which utilize different mechanisms, one in which the vaccine take differs for each subtype, and the other in which a different level of reduced infectivity results after infection by each subtype. The equilibrium outcome is different for each case; equilibrium coexistence of the two subtypes is possible in the differential take model, but not in the differential reduced infectivity model. This is a first step in understanding the interaction of HIV subtypes and differentially effective vaccines with different modes of action.HIV vaccine, mathematical model, HIV-1 subtype, HIV-1 clade, competitive exclusion,

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Molecular epidemiology of HIV-1 in Madrid

Cited by 17 publications

References 30 publications

Designing HIV Vaccination Policies: Subtypes and Cross-Immunity

Designing HIV Vaccination Policies: Subtypes and Cross-Immunity

Sequence analysis of HIV-1vif gene in Spanish isolates

HIV vaccines: The effect of the mode of action on the coexistence of HIV subtypes

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