Molecular evolution of the six internal genes of H5N1 equine influenza A virus

Abdel‐Moneim, Ahmed S.; Shehab, Gaber M. G.; Abuelsaad, Abdelaziz S. A.

doi:10.1007/s00705-011-0966-3

Cited by 10 publications

(4 citation statements)

References 42 publications

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“…Key changes in this polymerase protein increase virus replication in mammals (Gao et al , 2009; Yamada et al , 2010). Our data show that this mutation is still common in Egyptian viruses, as reported previously (Abdel-Moneim et al , 2011; Kayali et al , 2011b), and was found in all viruses of the new cluster.…”

Section: Discussionsupporting

confidence: 88%

Molecular characterization of avian influenza H5N1 virus in Egypt and the emergence of a novel endemic subclade

El-Shesheny

Kandeil

Bagato

et al. 2014

Journal of General Virology

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Clade 2.2 highly pathogenic H5N1 viruses have been in continuous circulation in Egyptian poultry since 2006. Their persistence caused significant genetic drift that led to the reclassification of these viruses into subclades 2.2.1 and 2.2.1.1. Here, we conducted full-genome sequence and phylogenetic analyses of 45 H5N1 isolated during 2006-2013 through systematic surveillance in Egypt, and 53 viruses that were sequenced previously and available in the public domain. Results indicated that H5N1 viruses in Egypt continue to evolve and a new distinct cluster has emerged. Mutations affecting viral virulence, pathogenicity, transmission, receptor-binding preference and drug resistance were studied. In light of our findings that H5N1 in Egypt continues to evolve, surveillance and molecular studies need to be sustained.

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Section: Discussionsupporting

confidence: 88%

Molecular characterization of avian influenza H5N1 virus in Egypt and the emergence of a novel endemic subclade

El-Shesheny

Kandeil

Bagato

et al. 2014

Journal of General Virology

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“…Still needing an answer is the question of whether such peculiar amino acids play a role in the virulence and/or transmission of H5N1 virus to equine or not. 128 Other animals…”

Section: H5n1mentioning

confidence: 99%

Epidemiology, ecology and gene pool of influenza A virus in Egypt: Will Egypt be the epicentre of the next influenza pandemic?

Abdelwhab

Abdel‐Moneim

2015

Virulence

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“…Several amino acid sites (AASs) in IAV RNPs were reported to affect IAV RNP activity or were associated with IAV host adaptation [15]–[31]. In total, 99 AASs (25 in the PA protein, 16 in the PB1 protein, 31 in the PB2 protein and 27 in the NP protein) from these reports were mapped to 185 SLiMs (42 in the PA protein, 35 in the PB1 protein, 67 in the PB2 protein and 41 in the NP protein) identified in this study (Table 2– 5).…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study of Short Linear Motif Compositions of the Influenza A Virus Ribonucleoproteins

Yang

2012

PLoS ONE

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Protein-protein interactions through short linear motifs (SLiMs) are an emerging concept that is different from interactions between globular domains. The SLiMs encode a functional interaction interface in a short (three to ten residues) poorly conserved sequence. This characteristic makes them much more likely to arise/disappear spontaneously via mutations, and they may be more evolutionarily labile than globular domains. The diversity of SLiM composition may provide functional diversity for a viral protein from different viral strains. This study is designed to determine the different SLiM compositions of ribonucleoproteins (RNPs) from influenza A viruses (IAVs) from different hosts and with different levels of virulence.The 96 consensus sequences (regular expressions) of SLiMs from the ELM server were used to conduct a comprehensive analysis of the 52,513 IAV RNP sequences. The SLiM compositions of RNPs from IAVs from different hosts and with different levels of virulence were compared. The SLiM compositions of 845 RNPs from highly virulent/pandemic IAVs were also analyzed. In total, 292 highly conserved SLiMs were found in RNPs regardless of the IAV host range. These SLiMs may be basic motifs that are essential for the normal functions of RNPs. Moreover, several SLiMs that are rare in seasonal IAV RNPs but are present in RNPs from highly virulent/pandemic IAVs were identified.The SLiMs identified in this study provide a useful resource for experimental virologists to study the interactions between IAV RNPs and host intracellular proteins. Moreover, the SLiM compositions of IAV RNPs also provide insights into signal transduction pathways and protein interaction networks with which IAV RNPs might be involved. Information about SLiMs might be useful for the development of anti-IAV drugs.

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Molecular evolution of the six internal genes of H5N1 equine influenza A virus

Cited by 10 publications

References 42 publications

Molecular characterization of avian influenza H5N1 virus in Egypt and the emergence of a novel endemic subclade

Molecular characterization of avian influenza H5N1 virus in Egypt and the emergence of a novel endemic subclade

Epidemiology, ecology and gene pool of influenza A virus in Egypt: Will Egypt be the epicentre of the next influenza pandemic?

A Comparative Study of Short Linear Motif Compositions of the Influenza A Virus Ribonucleoproteins

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