Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology

Liu, Zhidong; Wang, Miao; Zhang, Chunbo; Zhou, Shigao; Ji, Guang

doi:10.2147/dmso.s346648

Cited by 43 publications

(23 citation statements)

References 144 publications

(139 reference statements)

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“…It has six compact domains that can bind to six Cu atoms. Cp carries 40–70% of Cu in plasma and plays important roles in Cu transport, iron (Fe) regulation, free radical scavenging, and antioxidant processes [ 133 ]. Among the numerous NBIA, Aceruloplasminemia has the highest level of iron accumulation and it has the final impact on the liver, pancreas, retina, and many brain regions, including basal ganglia and cortex [ 134 ].…”

Section: Other Iron-related Neurological Diseasesmentioning

confidence: 99%

Iron Metabolism in Aging and Age-Related Diseases

Tian

Yuan

et al. 2022

IJMS

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Iron is a trace metal element necessary to maintain life and is also involved in a variety of biological processes. Aging refers to the natural life process in which the physiological functions of the various systems, organs, and tissues decline, affected by genetic and environmental factors. Therefore, it is imperative to investigate the relationship between iron metabolism and aging-related diseases, including neurodegenerative diseases. During aging, the accumulation of nonheme iron destroys the stability of the intracellular environment. The destruction of iron homeostasis can induce cell damage by producing hydroxyl free radicals, leading to mitochondrial dysfunction, brain aging, and even organismal aging. In this review, we have briefly summarized the role of the metabolic process of iron in the body, then discussed recent developments of iron metabolism in aging and age-related neurodegenerative diseases, and finally, explored some iron chelators as treatment strategies for those disorders. Understanding the roles of iron metabolism in aging and neurodegenerative diseases will fill the knowledge gap in the field. This review could provide new insights into the research on iron metabolism and age-related neurodegenerative diseases.

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Section: Other Iron-related Neurological Diseasesmentioning

confidence: 99%

Iron Metabolism in Aging and Age-Related Diseases

Tian

Yuan

et al. 2022

IJMS

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“…Human serum albumin is in equilibrium with other copper molecules circulating in the blood. When free molecules in the circulation disrupt this balance, the course of Alzheimer's disease accelerates [44] . As a result of the study, it was revealed that the decrease in the level of Cu metal in the brains of Alzheimer's disease increased the level of nCp‐Cu in the blood of these patients.…”

Section: Resultsmentioning

confidence: 94%

“…When free molecules in the circulation disrupt this balance, the course of Alzheimer's disease accelerates. [44] As a result of the study, it was revealed that the decrease in the level of Cu metal in the brains of Alzheimer's disease increased the level of nCp-Cu in the blood of these patients. Human serum albumin protein plays an important role in the antioxidant defense system.…”

Section: Findings Of Ache and Bche Enzymes Activitymentioning

confidence: 91%

Determination of the Antioxidant Capacity of Puerarin and Its Effect on Cholinesterases by in vitro and in silico Methods

İnan Ergün,

Topal

2023

ChemistrySelect

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Puerarin, which was used as a natural isoflavone in this study, was obtained from the Kudzu plant. The inhibitory effect of puerarin on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes was investigated. The IC50 values of AChE (177.73 nM) and BChE (315.07 nM) were determined. The binding mechanism of puerarin, which has a high inhibitory effect on the active site of the enzyme, was demonstrated by the molecular docking method. The antioxidant activity was evaluated for the same molecule. For this purpose, Fe3+‐Fe2+ reducing capacity, ABTS radical scavenging activity, CUPRAC method, DPPH⋅ scavenging activity and DMPD radical scavenging method were used. The percentage (%) inhibition amount of puerarin molecule was calculated as 99.33 % for ABTS radical scavenging activity, which is the more preferred method for natural products. The absorbtion value of iron reduction of Puerarin was 0.122±0.010, and the value of copper reduction was 0.633±0.026. Our research efforts include uncovering the potent antioxidant potential of puerarin and, simultaneously, a comparative study of tacrine, primarily emphasizing its inhibitory effects against AChE and BChE enzymes. The puerarin is expected to be a guide for drug discovery against many problems, especially oxidative cell damage in Alzheimer's disease, mitochondrial dysfunction (MD), cancer, and cardiovascular diseases.

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“…The higher concentration of ceruloplasmin with antioxidant properties in the J&J group, than in the Biomet group, and its positive correlation with chromium ions should be interpreted analogously. On the other hand, ceruloplasmin is also an acute phase protein [ 36 ], so an increase in its concentration may be associated with the occurrence of inflammation. The limitation of this study is the significant difference between the average age of people in the studied groups, which makes it difficult to interpret the markers of oxidative stress and the antioxidant function of the organism.…”

Section: Discussionmentioning

confidence: 99%

The concentration of chromium and cobalt ions and parameters of oxidative stress in serum and their impact on clinical outcomes after metaphyseal hip arthroplasty with modular metal heads

et al. 2023

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Purpose Current epidemiological data forecast an almost 40% increase in the number of hip arthroplasty performed in the population of patients with osteoarthritis in 2060, compared to year 2018. On the basis of 10 years of observation, the failure rate after a metal-on-metal hip replacement is between 56.7 and 88.9%, depending on the used implant. Methods Seventy-six men operated using metaphyseal hip prostheses, with modular metal heads: the J&J DePuy ASR and Biomet Recap-Magnum systems, after a period of about 5–7 years after the procedure, were assessed twice (an interval of 6 months) in terms of the parameters of oxidative stress and the concentration of chromium, cobalt and ions nickel, as well as their impact on the current clinical status and quality of life. Results The mean values of the Co and Cr ion concentrations increased in a statistically significant manner at the individual stages of the study (13.20 Co and 18.16 Cr) for J&J DePuy ASR. Using the WOMAC-hip, HHS and SF-12 rating scales, the functional status of operated patients in both study groups did not change in a statistically significant manner during subsequent visits. There was a statistically significant increase in perceived pain in patients operated bilaterally with the J&J DePuy ASR system. The severity of pain could be related to the increase in the concentration of Co and Cr ions; however, it concerned a small group of bilaterally operated patients (n = 3 + n = 4). Conclusions Metal-on-metal configuration in hip arthroplasty significantly influences with the increase in the concentration of chromium and cobalt ions in a double assessment. A statistically significant increase in the concentration of the tested Co and Cr ions in the blood correlates with an increase in the intensity of pain, especially in patients undergoing bilateral surgery. The limitation of this study is the relatively small number of bilaterally operated patients. Elevated levels of Co and Cr ions in the blood of patients operated on with the J&J DePuy ASR system increased steadily during both follow-up visits.

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Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology

Cited by 43 publications

References 144 publications

Iron Metabolism in Aging and Age-Related Diseases

Iron Metabolism in Aging and Age-Related Diseases

Determination of the Antioxidant Capacity of Puerarin and Its Effect on Cholinesterases by in vitro and in silico Methods

The concentration of chromium and cobalt ions and parameters of oxidative stress in serum and their impact on clinical outcomes after metaphyseal hip arthroplasty with modular metal heads

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