1998
DOI: 10.1054/tuld.1998.0002
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Molecular genetic basis of antimicrobial agent resistance inMycobacterium tuberculosis: 1998 update

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Cited by 971 publications
(1,072 citation statements)
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References 260 publications
(327 reference statements)
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“…This is consistent with the observation that unusually high proportion of Ser315Thr mutation is characteristic of INH-resistant strains in Russia [31][32][33]. As previously reported, mutations in codons 531, 526 and 516 of rpoB are responsible for 86-100% of RIF-resistant TB cases in Russia in agreement with other global reports originating from regions with high rates of MDR-TB [34]. This was also seen in Murmansk, where mutations in codon rpoB531 accounted for 91.2 % (n=104) of the RIF resistance among the primary MDR isolates.…”
Section: Discussionsupporting
confidence: 92%
“…This is consistent with the observation that unusually high proportion of Ser315Thr mutation is characteristic of INH-resistant strains in Russia [31][32][33]. As previously reported, mutations in codons 531, 526 and 516 of rpoB are responsible for 86-100% of RIF-resistant TB cases in Russia in agreement with other global reports originating from regions with high rates of MDR-TB [34]. This was also seen in Murmansk, where mutations in codon rpoB531 accounted for 91.2 % (n=104) of the RIF resistance among the primary MDR isolates.…”
Section: Discussionsupporting
confidence: 92%
“…Foram encontradas mutações em múltiplos códons que resultaram em dois, três ou quatro aminoácidos diferentes na proteína EmbB. 28 Para a total compreensão dos mecanismos utilizados pela micobactéria para aquisição de resistência ao EMB, ainda se faz necessária a identificação de outros locais ou mutações que podem ocorrer nesses organismos resistentes, possibilitando estudos bioquímicos e de variantes moleculares envolvidas nesse processo.…”
Section: Resistência Ao Etambutolunclassified
“…The above mentioned serious concerns has leads to the development of new anti-tubercular drugs. The internal resistance of M.tuberculosis is due to several factors such as active drug efflux mechanism, highly permeable mycolic acid containing cell wall and the production of drug modifying and drug inactivating enzymes (Ramaswamy S, et al, 1998). M.tuberculosis contains unique signature fatty acids and mycolic acids that are unusually long chain α-alkyl and β-hydroxy fatty acids of 60-90 carbons (Takayama K, et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…The replacement of an amino acid in the NADH binding site of InhA apparently results in INH resistance, preventing the inhibition of mycolic acid biosynthesis (Zhang YM, et al, 2006). Various genetic mutations have been observed to occur usually between codons 138 and 328 (Ramaswamy S, et al, 1998). The Ser-315-Thr mutation is most frequent and found in about 40% of all INH-resistant strains (Marttila HJ, et al, 1998, Zhang YM, et al, 2006.…”
mentioning
confidence: 99%