Molecular-Genetic «portrait» of Breast Cancer

Лаптиев, С. А.; Корженевская, М. А.; Имянитов, Е. Н.

doi:10.24884/1607-4181-2017-24-2-12-22

Cited by 4 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Следовательно, гены молекулярных подтипов РМЖ могут служить в качестве биомаркеров и помочь при составлении алгоритма лечения и прогнозировании течения заболевания. Люминальный А и люминальный В подтипы РМЖ отличаются механизмами пролиферации и патологическими путями регуляции гормонального баланса [25]. Опухоли люминального А подтипа имеют высокую экспрессию генов, ответственных за гормональную регуляцию, таких как гены прогестероновых рецепторов и FOXA1 (Forkhead Box Protein A1), в то время как у опухолей люминального В подтипа имеется тенденция к обратному регулированию генов MKI67 (Marker of Proliferation Ki-67), FGFR1 (Fibroblast Growth Factor Receptor 1 -рецептор фактора роста фибробластов 1) [26] и AURKA (Aurora Kinase A) [27].…”

Section: биомаркеры молекулярных подтипов рака молочной железыunclassified

The role of biomarkers in the early diagnostics of breast cancer

Исмагилов

Хузина²,

Ванесян³

et al. 2021

Opuholi ženskoj reproduktivnoj sistemy

View full text Add to dashboard Cite

One of the main priorities in modern oncology is the identification and clinical application of biomarkers that can be helpful in the diagnostics and prognostication of cancer. The aim of this article was to review biomarkers for early diagnosis and prediction of prognosis of breast cancer. There were reviewed three main groups of biomarkers in this article: familial breast cancer biomarkers with high and low penetration (BRCA1, BRCA2, TP53, etc.), biomarkers of breast cancer molecular subtypes (luminal A and luminal B, HER2/neu, basal and low in claudine) and biomarkers of early stage breast cancer progression (multigenic panels).

show abstract

Section: биомаркеры молекулярных подтипов рака молочной железыunclassified

The role of biomarkers in the early diagnostics of breast cancer

Исмагилов

Хузина²,

Ванесян³

et al. 2021

Opuholi ženskoj reproduktivnoj sistemy

View full text Add to dashboard Cite

show abstract

“…Cancer formation is a multistep, multistep process involving cellular and molecular events [2]. At all its stages, in an initially healthy single cell, there is a gradual accumulation of genetic changes in DNA, caused by endogenous and exogenous factors, leading to "disruption of its mitotic activity" [3]. Damage affects the integrity and stability of DNA, but is constantly and efficiently corrected by DNA repair pathways [4].…”

Section: Introductionmentioning

confidence: 99%

Functional polymorphisms of oxidative stress and repair genes as biomarkers of the risk of developing breast cancer

Bisultanova,

Dzhambetova,

Dzhambetova

2023

BIO Web Conf.

View full text Add to dashboard Cite

Breast cancer has the highest incidence and is the fifth leading cause of death in women worldwide. Cancer formation is a multistep, multistep process involving cellular and molecular events. At all its stages, in an initially healthy single cell, there is a gradual accumulation of genetic changes in DNA caused by endogenous and exogenous factors. Breast cancer-predisposing mutations are not evenly distributed among populations, and each ethnic group is descended from its own pool of ancestors who carried a unique spectrum of alleles associated with the disease, making it imperative that studies of this kind be conducted to identify “population-specific markers.”

show abstract

Mutations in tumor suppressor genes and their relationship with phenotypic features of breast cancer in young age women

Гордеева

Александровна²,

Lojko³

et al. 2018

Ecological genetics

View full text Add to dashboard Cite

Background. Breast cancer (BC) is the most common oncological disease in women in the world. The aim of study is to investigate the frequencies of mutations in BRCA1 5382insC (rs80357906), CHEK2 1100delC (rs555607708) and BLM c.1642 C>T (rs200389141) genes and their relationship with the phenotypic features of BC in 104 young age women. Materials and methods. We studied 104 young age women with breast cancer. Typing of mutations BRCA1 5382insC, CHEK2 1100delC and BLM c.1642 C>T genes were performed by real-time PCR followed by melting analysis. Results. The BRCA1 5382insC mutation was detected in 9.6% of BC patients. The BRCA1 5382insC mutation was correlated with the lack of expression of estrogen receptors (χ2 = 18.48, d(f) = 1, p < 0.0001), the HER2/neo tumor receptor (χ2 = 5.61, d(f) = 1, p < 0.02). The BRCA1 5382insC mutation was more often in the “triple negative” BC (χ2 = 17.42, d(f) = 3, p < 0.001). Luminal A subtype of disease was observed the predominantly in non-carriers of the mutation BRCA1 5382insC (sporadic breast cancer). The founder mutations in the CHEK2 1100delC and BLM c.1642 C>T genes were absent in young age women with BC. Conclusion. Our results confirm the high significance of detecting the BRCA1 rs80357906 mutation in young age women with BC for optimization of treatment tactic and for early diagnosis of BC.

show abstract

Molecular-Genetic «portrait» of Breast Cancer

Cited by 4 publications

References 2 publications

The role of biomarkers in the early diagnostics of breast cancer

The role of biomarkers in the early diagnostics of breast cancer

Functional polymorphisms of oxidative stress and repair genes as biomarkers of the risk of developing breast cancer

Mutations in tumor suppressor genes and their relationship with phenotypic features of breast cancer in young age women

Contact Info

Product

Resources

About