Molecular genetics and breeding of vegetable brassicas

King, Graham J.

doi:10.1007/bf00023632

Cited by 16 publications

(5 citation statements)

References 83 publications

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“…In studies looking at animal feed rich in cruciferous vegetables, a reduction in fertility of male and female animals, as well as growth reduction, and reduction in milk and egg production have been observed . Furthermore, glucosinolate hydrolysis may cause irritation of gastro‐intestinal mucosa, which may lead to local necrosis and hepatotoxicity …”

Section: In Vitro and In Vivo Studies Of Isothiocyanates And Bladder mentioning

confidence: 99%

“…[120] Furthermore, glucosinolate hydrolysis may cause irritation of gastro-intestinal mucosa, which may lead to local necrosis and hepatotoxicity. [121] There have even been studies that have linked isothiocyanates, in low concentrations, with compromising the function of immune cells and impairing genome stability. [122] Isothiocyanates are extremely electrophilic and have the ability to bind sulphydryl groups of biologically important molecules, contributing to their potential toxicity.…”

Section: Potential Toxicity Of Isothiocyanatesmentioning

confidence: 99%

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Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention

Abbaoui

Lucas

Riedl

et al. 2018

Molecular Nutrition Food Res

132

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Bladder cancer is a significant health burden due to its high prevalence, risk of mortality, morbidity, and high cost of medical care. Epidemiologic evidence suggests that diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk. Phytochemicals in cruciferous vegetables, such as glucosinolates, which are enzymatically hydrolyzed to bioactive isothiocyanates, are possible mediators of an anticancer effect. In vitro studies have shown inhibition of bladder cancer cell lines, cell cycle arrest, and induction of apoptosis by these isothiocyanates, in particular sulforaphane and erucin. Although not yet completely understood, many mechanisms of anticancer activity at the steps of cancer initiation, promotion, and progression have been attributed to these isothiocyanates. They target multiple pathways including the adaptive stress response, phase I/II enzyme modulation, pro-growth, pro-survival, pro-inflammatory signaling, angiogenesis, and even epigenetic modulation. Multiple in vivo studies have shown the bioavailability of isothiocyanates and their antitumoral effects. Although human studies are limited, they support oral bioavailability with reasonable plasma and urine concentrations achieved. Overall, both cell and animal studies support a potential role for isothiocyanates in bladder cancer prevention and treatment. Future studies are necessary to examine clinically relevant outcomes and define guidelines on ameliorating the bladder cancer burden.

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Section: In Vitro and In Vivo Studies Of Isothiocyanates And Bladder mentioning

confidence: 99%

Section: Potential Toxicity Of Isothiocyanatesmentioning

confidence: 99%

Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention

Abbaoui

Lucas

Riedl

et al. 2018

Molecular Nutrition Food Res

132

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“…The efficiency of these backcrossing programmes can be expected to increase significantly with the development of molecular markers within Brassica (King, 1990) . The efficiency of these backcrossing programmes can be expected to increase significantly with the development of molecular markers within Brassica (King, 1990) .…”

Section: Manipulation Of Leaf Glucosinolate Profilesmentioning

confidence: 99%

Leaf glucosinolate profiles and their relationship to pest and disease resistance in oilseed rape

Mithen

1992

Euphytica

150

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“…The diploid species are morphologically more diverse than B. napus and it is likely that they contain agronomically useful genes which do not occur within the existing B. napus primary genepool. The rate of introgression of genes from the diploid Brassica species into B. napus cultivars is likely to increase considerably with the development of molecular markers for agronomic traits (KING 1990).…”

mentioning

confidence: 99%

Glucosinolates and Resistance to Leptosphaeria maculans in Wild and Cultivated Brassica Species

Mithen

Magrath

1992

Plant Breeding

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Synthetic lines of Brassica napus were derived by combining the genomes of B. atlantica and B. oleracea var. alboglabra, which were respectively resistant and susceptible to foliar infection by Leptosphaeria maculans, with a susceptible line of B. rapa. Resistance was expressed in the synthetic lines containing the genome of B. atlantica. The high levels of alkenyl glucosinolates which occur in leaves of B. atlantica, and which have been implicated in disease resistance, were also expressed within the synthetic lines, although the dominant glucosinolate had changed from sinigrin to glucobrassicanapin. Disease resistance and glucosinolate profiles did not co-segregate in F2 progeny from crosses between the synthetic lines.

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Molecular genetics and breeding of vegetable brassicas

Cited by 16 publications

References 83 publications

Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention

Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention

Leaf glucosinolate profiles and their relationship to pest and disease resistance in oilseed rape

Glucosinolates and Resistance to Leptosphaeria maculans in Wild and Cultivated Brassica Species

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