Molecular genetics of hereditary hair and nail disease

Steensel, M.A.M. van; Geel, Michel van; Steijlen, P.M.

doi:10.1002/ajmg.c.30034

Cited by 4 publications

(1 citation statement)

References 66 publications

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“…It is part of a multiprotein complex containing Axin, PP2B, Gsk3ß and the "tumor suppressor"^ protein APC [37][38][39] . If unchecked by an external signal, Gsk3ß phosphorylates ß-catenin, marking it for degradation through the ubiquitin pathway 40 . However, upon receipt of a Wnt signal, the degradation machinery becomes inactive and ß-catenin is stabilized.…”

Section: Initiation Of Hair Follicle Differentiationmentioning

confidence: 99%

Clinical and molecular genetic studies in hereditary hair loss

Steensel

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