Molecular genetics of the fruit-fly circadian clock

Rosato, Ezio; Tauber, Eran; Kyriacou, Charalambos P.

doi:10.1038/sj.ejhg.5201547

Cited by 47 publications

(34 citation statements)

References 139 publications

(115 reference statements)

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“…Combined with genetic studies in a variety of organisms, notably in Drosophila and mouse, these findings have led to the elucidation of the basic molecular mechanisms of the circadian clock ( Fig. 1; for review see, Ko & Takahashi 2006;Rosato et al 2006). The core clock elements turned out to be transcription factors participating in a delayed feedback loop that leads to oscillating gene transcription.…”

Section: The Molecular Clockwork -A Transcriptional Negative Feedbackmentioning

confidence: 99%

Glucocorticoids and the circadian clock

Dickmeis¹

2008

Journal of Endocrinology

418

292

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Glucocorticoids, hormones produced by the adrenal gland cortex, perform numerous functions in body homeostasis and the response of the organism to external stressors. One striking feature of their regulation is a diurnal release pattern, with peak levels linked to the start of the activity phase. This release is under control of the circadian clock, an endogenous biological timekeeper that acts to prepare the organism for daily changes in its environment. Circadian control of glucocorticoid production and secretion involves a central pacemaker in the hypothalamus, the suprachiasmatic nucleus, as well as a circadian clock in the adrenal gland itself. Central circadian regulation is mediated via the hypothalamic-pituitary-adrenal axis and the autonomic nervous system, while the adrenal gland clock appears to control sensitivity of the gland to the adrenocorticopic hormone (ACTH). The rhythmically released glucocorticoids in turn might contribute to synchronisation of the cell-autonomous clocks in the body and interact with them to time physiological dynamics in their target tissues around the day.

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Section: The Molecular Clockwork -A Transcriptional Negative Feedbackmentioning

confidence: 99%

Glucocorticoids and the circadian clock

Dickmeis¹

2008

Journal of Endocrinology

418

292

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“…Transcriptional feedback loops essential for cellular oscillation of clock neurons have been studied extensively and are well understood (for review, see Harmer et al, 2001;Hardin, 2005;Rosato et al, 2006). Cellular oscillation also relies on depolarizationdependent events at the clock neuron plasma membrane (Nitabach et al, 2002(Nitabach et al, , 2005Wu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Circadian Control of Membrane Excitability in Drosophila melanogaster Lateral Ventral Clock Neurons

Cao¹,

Nitabach²

2008

Journal of Neuroscience

147

182

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“…The molecular mechanisms underlying these internal rhythms and their entrainment by external cues are best understood in the fruit fly Drosophila melanogaster (Helfrich-Förster, 2005;Rosato et al, 2006;Stanewsky, 2002). Photic entrainment in Drosophila is largely accomplished by the flavoprotein cryptochrome (dCRY), which acts as a circadian photoreceptor (Emery et al, , 2000bStanewsky et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Daily Changes in Ultraviolet Light Levels Can Synchronize the Circadian Clock of Bumblebees (Bombus terrestris)

Chittka

Stelzer

Stanewsky

2013

Chronobiology International

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Endogenous circadian clocks are synchronized to the 24-h day by external zeitgebers such as daily light and temperature cycles. Bumblebee foragers show diurnal rhythms under daily light:dark cycles and short-period freerunning circadian rhythms in constant light conditions in the laboratory. In contrast, during the continuous light conditions of the arctic summer, they show robust 24-h rhythms in their foraging patterns, meaning that some external zeitgeber must entrain their circadian clocks in the presence of constant light. Although the sun stays above the horizon for weeks during the arctic summer, the light quality, especially in the ultraviolet (UV) range, exhibits pronounced daily changes. Since the photoreceptors and photopigments that synchronize the circadian system of bees are not known, we tested if the circadian clocks of bumblebees (Bombus terrestris) can be entrained by daily cycles in UV light levels. Bumblebee colonies were set up in the laboratory and exposed to 12 h:12 h UV + : UV− cycles in otherwise continuous lighting conditions by placing UV filters on their foraging arenas for 12 h each day. The activity patterns of individual bees were recorded using fully automatic radiofrequency identification (RFID). We found that colonies manipulated in such a way showed synchronized 24-h rhythms, whereas simultaneously tested control colonies with no variation in UV light levels showed free-running rhythms instead. The results of our study show that bumblebee circadian rhythms can indeed be synchronized by daily cycles in ambient light spectral composition. (Author correspondence: r.stanewsky@qmul.ac.uk)

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Molecular genetics of the fruit-fly circadian clock

Cited by 47 publications

References 139 publications

Glucocorticoids and the circadian clock

Glucocorticoids and the circadian clock

Circadian Control of Membrane Excitability in Drosophila melanogaster Lateral Ventral Clock Neurons

Daily Changes in Ultraviolet Light Levels Can Synchronize the Circadian Clock of Bumblebees (Bombus terrestris)

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