Molecular, genomic, and expressional delineation of a piscidin from rock bream (Oplegnathus fasciatus) with evidence for the potent antimicrobial activities of Of-Pis1 peptide

Antimicrobial peptides from fish: beyond the fight against pathogens

“…Although less studied, probably because of their lesser economic impact in aquaculture, the antifungal and antiparasitic activities of several AMPs have also received attention. Piscidin-2 from hybrid striped bass demonstrated potent antifungal efficiency against human fungal pathogens Candida albicans, Trichosporon beigelii and Malassezia furfur (Sung et al 2008) as happens with Ofpis-1 and Oreoch-1, -2 and -3 in the case of C. albicans, but also shows this function against Saccharomyces cerevisiae (Umasuthan et al 2016;Acosta et al 2013). Regarding hepcidins, orangespotted grouper synthetic putative mature peptides ecPis-2S, -3S and -4S had strong antifungal activities against Pichia pastoris (Zhuang et al 2017).…”

“…; Umasuthan et al . ). Moreover, they also show an antibacterial function against antibiotic‐resistant bacteria strains (Noga et al .…”

“…albicans , but also shows this function against Saccharomyces cerevisiae (Umasuthan et al . ; Acosta et al . ).…”

“…Umasuthan et al . () demonstrated that Ofpis‐1 from rock bream possessed antiparasitic activity against Miamiensis avidus . Similarly, cationic piscidin‐1 and non‐cationic piscidin‐2 and the splicing variant piscidin‐2β from Atlantic cod demonstrated antiparasitic activity against Tetrahymena pyriformis ( T .…”

“…AMPs defend the host against a wide range of Gram + and Gram À bacteria (Table 3), mostly by direct antimicrobial action, which is attributed to their capacity to form pores and disrupt cell membranes (Olivieri et al 2015;Shabir et al 2018). Depending on the infective bacteria, AMPs are expressed in different fish tissues (Bae et al 2016;Umasuthan et al 2016). Moreover, they also show an antibacterial function against antibiotic-resistant bacteria strains (Noga et al 2009).…”