Molecular Identification and in silico Characterization of Coat Protein in Tomato Leaf Curl Virus Associated in Tomato from South Gujarat Region of India

In-Silico Interaction of Hydroxychloroquine Drug with Various Proteins of Coronavirus (SARS-CoV-2): A Computational Approaches to Combat COVID-19

“…Homology modelling of SARS-CoV2 receptor binding domain of PLPRO protein used against FDA approved drugs [9]. Ravindra and Kalaria, 2019 [21] also perform the validation of homology structure using Ramachandran plot of Tomato Leaf Curl Virus coat protein. Predicted homology model were subjected to validation using PRoSA based on Z-score and Procheck based on favourable amino acid.…”

In-Silico Interaction of Hydroxychloroquine Drug with Various Proteins of Coronavirus (SARS-CoV-2): A Computational Approaches to Combat COVID-19

“…These models were further subjected to analyze the improvement in energy-minimized protein. Evaluation of built model quality using swiss model was analyze through amino acid region in Ramachandran plot in procheck web server [28]; [21]. The models were chosen based on the percentage of support and frequency of outliers, which could be used for further study.…”

“…In silico studies have played crucial role in candidate drug prediction, computer aided drug design and molecular interaction in past decade [20]; [21]. To understand the targeted interaction between drugs and SARSCoV-2 proteins that could bind to receptor domains and help stop the spread of the virus.…”