Molecular identification, in vivo and in vitro activities of Calvatia gigantea (macro-fungus) as an antidiabetic agent

Ogbole, Omonike O.; Nkumah, Abraham O.; Linus, Augusta U.; Falade, Mofolusho O.

doi:10.1080/21501203.2019.1595204

Cited by 19 publications

(5 citation statements)

References 53 publications

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“…Fungi and their metabolites are the main source of bioactive molecules that show biological activity (Girometta 2019;Ogbole et al 2019). Among these sources, G. lucidum fruiting bodies have been reported to have antidiabetic activities.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures in type 2 diabetic rats

et al. 2020

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Tsaihttps://orcid.org/0000-0002-5605-5495 (2020): Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganodermalucidum cultures in type 2 diabetic rats, Mycology, ABSTRACTWe aim to investigate the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures and elucidate the potential mechanisms behind these effects using a type 2 diabetic rat model. Diabetic rats were daily fed with a high-fat diet supplemented with 1% or 3% freeze-dried whole submerged cultures of G. lucidum or mycelia for 5 weeks. We observed significantly decreased fasting plasma glucose levels, homoeostasis model assessment equationinsulin resistance, and plasma glucose in oral glucose tolerance test. Furthermore, we observed increased levels of glycogen, hepatic hexokinase, glucose-6-phosphate dehydrogenase, and intestinal disaccharidase activities. G. lucidum supplement downregulated the plasma levels of aspartate aminotransferase, alanine aminotransferase, creatinine, and urea nitrogen as well as liver and kidney levels of thiobarbituric acid reactive substances. Based on the hypoglycaemic and antioxidant effects of G. lucidum submerged cultures, we recommend the potential application of these products as functional foods or additives for controlling type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures in type 2 diabetic rats

et al. 2020

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“…In order to clarify possible adverse reactions and mechanisms of action, it is necessary to have a better understanding of the bioactive compounds in Ganoderma sp., which will be beneficial for clinical applications (Basnet et al 2017). Recently, Ogbole et al (2019) have identified and authenticated a puffball mushroom using molecular tools and investigated its anti-diabetic properties of crude extract and partitioned fractions in vitro and in vivo. By using a similar strategy, further research is needed to identify the active ingredients that contribute to the regulation of lipid metabolism by submerged G. lucidum cultures.…”

Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum culture supplement ameliorates dyslipidemia and reduces visceral fat accumulation in type 2 diabetic rats

et al. 2020

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Diabetic rats were daily fed with a high-cholesterol diet containing 1% or 3% freeze-dried whole submerged G. lucidum culture or its mycelia for 5 weeks. Body weight, adipose tissue weight and plasma triglyceride levels were reduced, while high-density lipoprotein-cholesterol levels were elevated in rats fed with G. lucidum powder supplement diets. Notably, G. lucidum supplements downregulated the activities of hepatic acetyl-CoA carboxylase, fatty acid synthase and lipoprotein lipase, but upregulated the activity of hormone-sensitive lipase in the perirenal adipose tissues. Moreover, G. lucidum supplements increased the faecal triglyceride excretion. Therefore, daily supplementation of submerged G. lucidum culture, especially mycelia, can ameliorate dyslipidemia and reduce visceral fat accumulation in diabetic rats fed with a high-fat diet, which is closely related to the modulation of lipid synthesis, metabolism, and excretion.

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“…The Calvatia gigantea belongs to the family Lycoperdaceae and is commonly used traditional medicinal edible fungus, which has multiple pharmacological effects, including antimicrobial, anti-inflammatory, anti-tussive, anti-cancer, and suppressing cell growth effects ( 1 – 5 ). Since little has been known about the genomic information of Lycoperdaceae species, here, we presented a high-quality draft genome assembly of Calvatia gigantea CGMCC5.9 obtained from the China General Microbiological Culture Collection Center (CGMCC) as a reference for future studies of this fungus.…”

Section: Announcementmentioning

confidence: 99%

Genome sequence of a traditional medicinal edible fungus Calvatia gigantea CGMCC5.9

Shi,

Chu,

Lin

et al. 2024

Microbiol Resour Announc

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Molecular identification, in vivo and in vitro activities of Calvatia gigantea (macro-fungus) as an antidiabetic agent

Abstract: View related articles View Crossmark data Citing articles: 5 View citing articles Molecular identification, in vivo and in vitro activities of Calvatia gigantea (macro-fungus) as an antidiabetic agent

Cited by 19 publications

References 53 publications

Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures in type 2 diabetic rats

Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures in type 2 diabetic rats

Ganoderma lucidum culture supplement ameliorates dyslipidemia and reduces visceral fat accumulation in type 2 diabetic rats

Genome sequence of a traditional medicinal edible fungus Calvatia gigantea CGMCC5.9

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