Molecular imaging of diabetes and diabetic complications: Beyond pancreatic β-cell targeting

Yang, Jichun; Zhang, Long Jiang; Wang, Fan; Hong, Tianpei; Liu, Zhaofei

doi:10.1016/j.addr.2018.11.007

Cited by 20 publications

(12 citation statements)

References 257 publications

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“…Type 1 diabetes is described as immune-mediated destruction of pancreatic β cells, and the characteristics of type 2 diabetes are insulin resistance and progressive β-cell failure ( Yang et al, 2018 ). Diabetes is a major metabolic disorder with high prevalence and is a risk factor for relevant public health issues such as cardiovascular disease, retinopathy, microangiopathy, and impaired wound healing ( Yang et al, 2018 ).…”

Section: Effect Of ω-3 Pufa-derived Oxylipins On Diabetesmentioning

confidence: 99%

Effect of ω-3 Polyunsaturated Fatty Acids-Derived Bioactive Lipids on Metabolic Disorders

2021

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Arachidonic acid (ARA) is an important ω-6 polyunsaturated fatty acid (PUFA), and docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and n-3 docosapentaenoic acid (n-3 DPA) are three well-known ω-3 PUFAs. These fatty acids can be metabolized into a number of bioactive lipids. Eicosanoids derived from ARA have drawn great attention because of their important and complex biofunctions. Although EPA, DHA and n-3 DPA have also shown powerful biofunctions, we have fewer studies of metabolites derived from them than those from ARA. Recently, growing research has focused on the bioaction of ω-3 PUFA-derived metabolites, which indicates their great potential for treating metabolic disorders. Most of the functional studies of these bioactive lipids focused on their anti-inflammatory effects. However, several studies elucidated their direct effects on pancreatic β cells, hepatocytes, adipocytes, skeletal muscle cells, and endothelial cells. These researches revealed the importance of studying the functions of metabolites derived from ω-3 polyunsaturated fatty acids other than themselves. The current review summarizes research into the effects of ω-3 PUFA-derived oxylipins on metabolic disorders, including diabetes, non-alcoholic fatty liver disease, adipose tissue dysfunction, and atherosclerosis.

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Section: Effect Of ω-3 Pufa-derived Oxylipins On Diabetesmentioning

confidence: 99%

Effect of ω-3 Polyunsaturated Fatty Acids-Derived Bioactive Lipids on Metabolic Disorders

2021

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“…Moreover, the radiation exposure of PET imaging is much lower than that of CT scan. In addition, the evaluation of the BCM level has a significant effect through PET imaging ( Wei et al, 2019 ; Yang et al, 2019 ). However, the high cost of PET has limited its promotion.…”

Section: Future Perspectivesmentioning

confidence: 99%

Elucidating the Relationship Between Diabetes Mellitus and Parkinson’s Disease Using 18F-FP-(+)-DTBZ, a Positron-Emission Tomography Probe for Vesicular Monoamine Transporter 2

et al. 2020

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Diabetes mellitus (DM) and Parkinson’s disease (PD) have been and will continue to be two common chronic diseases globally that are difficult to diagnose during the prodromal phase. Current molecular genetics, cell biological, and epidemiological evidences have shown the correlation between PD and DM. PD shares the same pathogenesis pathways and pathological factors with DM. In addition, β-cell reduction, which can cause hyperglycemia, is a striking feature of DM. Recent studies indicated that hyperglycemia is highly relevant to the pathologic changes in PD. However, further correlation between DM and PD remains to be investigated. Intriguingly, polycystic monoamine transporter 2 (VMAT2), which is co-expressed in dopaminergic neurons and β cells, is responsible for taking up dopamine into the presynaptic vesicles and can specifically bind to the β cells. Furthermore, we have summarized the specific molecular and diagnostic functions of VMAT2 for the two diseases reported in this review. Therefore, VMAT2 can be applied as a target probe for positron emission tomography (PET) imaging to detect β-cell and dopamine level changes, which can contribute to the diagnosis of DM and PD during the prodromal phase. Targeting VMAT2 with the molecular probe 18 F-FP-(+)-DTBZ can be an entry point for the β cell mass (BCM) changes in DM at the molecular level, to clarify the potential relationship between DM and PD. VMAT2 has promising clinical significance in investigating the pathogenesis, early diagnosis, and treatment evaluation of the two diseases.

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“…And, the changes in infiltrating lymphocytes and microvessels are both the symptoms of insulitis. Thus, before β‐cells are badly damaged, imaging of infiltrating lymphocytes or microvessels might provide early information for the identification of human at risk (Yang, Zhang, Wang, Hong, & Liu, 2019). However, there are also some researches claiming that, at any given time, even at the time of diagnosis, insulitis is typically present only in a certain percentage of islets and has a limited overall relationship with the duration of the disease (Pugliese, 2016).…”

Section: Nanotechnology In T1d Diagnosismentioning

confidence: 99%

“…And when the labeled cells were adoptively transferred to other NOD mice, they can be also visualized by MRI in islet samples from recipient mice (Anna Moore et al, 2002). Yet this method cannot quantify MR signal, and the labeling strategy is not antigen‐specific (Yang, Zhang, Wang, Hong, & Liu, 2019). So, in 2004, Pere Santamaria and his colleagues made magnetic NPs.…”

Section: Nanotechnology In T1d Diagnosismentioning

confidence: 99%

Nanotechnology's application in Type 1 diabetes

Pan

Zheng

Chen

et al. 2020

WIREs Nanomed Nanobiotechnol

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Molecular imaging of diabetes and diabetic complications: Beyond pancreatic β-cell targeting

Cited by 20 publications

References 257 publications

Effect of ω-3 Polyunsaturated Fatty Acids-Derived Bioactive Lipids on Metabolic Disorders

Effect of ω-3 Polyunsaturated Fatty Acids-Derived Bioactive Lipids on Metabolic Disorders

Elucidating the Relationship Between Diabetes Mellitus and Parkinson’s Disease Using 18F-FP-(+)-DTBZ, a Positron-Emission Tomography Probe for Vesicular Monoamine Transporter 2

Nanotechnology's application in Type 1 diabetes

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