Molecular impacts of perfluorinated chemicals (PFASs) in the liver and testis of male largemouth bass (Micropterus salmoides) in Minnesota Lakes

Collí-Dulá, Reyna Cristina; Martyniuk, Christopher J.; Streets, Summer; Denslow, Nancy D.; Lehr, Randy

doi:10.1016/j.cbd.2016.02.001

Cited by 16 publications

(25 citation statements)

References 51 publications

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“…In yellow perch an over-transcription of cat gene was observed in specimens from a PFAS polluted environment [321]. In largemouth bass (Micropterus salmoides) living in a PFOS polluted environment was observed an activation of gpx1a in testis and gpx4a in liver [332]. PFOS also triggered a mild increase in sod2 expression in chicken [319].…”

Section: Biomolecular Datamentioning

confidence: 95%

“…Finally, there are still other cases in which there was even a decrease in gene expression. This occurred in zebrafish, where exposure to PFAS significantly altered the gene transcription of sod1, cat, gpx1a, and prdx6 [281,308], in rare minnow, where gpx expression diminished in liver under treatment with PFOA [330], and in largemouth bass living in a PFOS polluted environment, where an inhibition of sod2, cat, prdx1, prdx3, and prdx4 was observed in various organs [332]. These inhibitions may be the result of a negative feedback control of gene expression but also of a toxic effect that can affect the activity of Nrf2.…”

Section: Biomolecular Datamentioning

confidence: 99%

“…Micropterus salmoides PFOS gpx up-regulation 8 , sod down-regulation 8 , cat up-regulation 8 , prdx down-regulation 8 [332] Mus musculus PFOA Lipid peroxidation 25 , amylase induction, lipase induction, sod1 up-regulation 5 , sod2 up-regulation5, gpx2 up-regulation 5 , nqo1 up-regulation 5 [204] Mus musculus PFOS Increased in peroxisomal fatty acid beta-oxidation 4 , increased peroxisomal catalase activity 4 [208] Mus musculus PFOA pparα up-regulation 5 , pparγ up-regulation 5 [209] Mus musculus PFOS Serum testosterone decrease 19 , epididymal sperm counts decrease, down-regulation of genes encoding testicular receptors for gonadotropin, growth hormone, insulin-like growth factor 1 and steroidogenic enzymes 5 [234] Mus musculus PFOA Damaged seminiferous tubules, reduced sperm quality, reduced serum testosterone and progesterone levels 13 , INSL3 enzyme decrease 23 , cytochrome P450 decrease 23 [235] Mus musculus PFOS Immune response induction 19 [269]…”

Section: Pfoa Pfosmentioning

confidence: 99%

See 2 more Smart Citations

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in the Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders, and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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Section: Biomolecular Datamentioning

confidence: 95%

Section: Biomolecular Datamentioning

confidence: 99%

Section: Pfoa Pfosmentioning

confidence: 99%

See 1 more Smart Citation

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…In yellow perch an over-transcription of cat gene was observed in specimens from a PFAS polluted environment [318]. In largemouth bass (Micropterus salmoides) living in a PFOS polluted environment was observed an activation of gpx1a in testis and gpx4a in liver [329]. PFOS also triggered a mild increase in sod2 expression in chicken [316].…”

Section: Biomolecular Datamentioning

confidence: 95%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato¹,

Corrà²,

Belli̇o³

et al. 2020

Preprint

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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“…PFASs are present in the environment and exposure can lead to accumulation in the human body over time. Animal studies show that PFASs can be toxic to the liver, thyroid, immune system and are potentially neurotoxic (Aimuzi et al, 2019;Berntsen et al, 2018;Cao et al, 2019;Colli-Dula et al, 2016;Harris et al, 2018;Nian et al, 2019;Niu et al, 2019;Steves et al, 2018). PFASs are classified based on chemical functionality and include commonly measured perfluorocarboxylic acids (perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA)), and perfluorosulfonates (perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonate (PFHxS)).…”

Section: Introductionmentioning

confidence: 99%

Structure-Based Virtual Screening of Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) as Endocrine Disruptors of Androgen Receptor Activity Using Molecular Docking and Machine Learning

Ramaprasad¹,

Tachachartvanich²,

Fourches³

et al. 2020

Preprint

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Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) pose a substantial threat as endocrine disruptors, and thus early identification of those that may interact with steroid hormone receptors, such as the androgen receptor (AR), is critical. In this study we screened 5,206 PFASs from the CompTox database against the different binding sites on the AR using both molecular docking and machine learning techniques. We developed support vector machine models trained on Tox21 data to classify the active and inactive PFASs for AR using different chemical fingerprints as features. The maximum accuracy was 95.01% and Matthew’s correlation coefficient (MCC) was 0.76 respectively, based on MACCS fingerprints (MACCSFP). The combination of docking-based screening and machine learning models identified 29 PFASs that have strong potential for activity against the AR and should be considered priority chemicals for biological toxicity testing.

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Molecular impacts of perfluorinated chemicals (PFASs) in the liver and testis of male largemouth bass (Micropterus salmoides) in Minnesota Lakes

Cited by 16 publications

References 51 publications

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Structure-Based Virtual Screening of Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) as Endocrine Disruptors of Androgen Receptor Activity Using Molecular Docking and Machine Learning

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