2002
DOI: 10.1039/b204949j
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Molecular imprinted polymer coated QCM for the detection of nandrolone

Abstract: An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively screen for nandrolone in the liquid phase. A highly specific covalently imprinted polymer (MIP) was spin coated on to one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the nandralone was observed as a frequency shift in the QCM for concentrations up to 0.2 ppm with the sensor binding shown to favour nandrolone over analogous compounds.

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Cited by 75 publications
(40 citation statements)
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“…On the other hand, excellent sensitivity was achievable, with a limit of detection of 2 ppb in the case of the L-serine-imprinted MIP-QCM. The group has also employed a covalent imprinting strategy 500 for the anabolic steroid nandrolone, with similar results. A 'sandwich casting' method, using a conventional MIP composition, was also used by Haupt et al 1257 in the development of a QCM sensor selective for S-propranolol, in what is the first literature example of an integrated MIP-QCM sensing device capable of chiral discrimination.…”
Section: 213mentioning
confidence: 66%
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“…On the other hand, excellent sensitivity was achievable, with a limit of detection of 2 ppb in the case of the L-serine-imprinted MIP-QCM. The group has also employed a covalent imprinting strategy 500 for the anabolic steroid nandrolone, with similar results. A 'sandwich casting' method, using a conventional MIP composition, was also used by Haupt et al 1257 in the development of a QCM sensor selective for S-propranolol, in what is the first literature example of an integrated MIP-QCM sensing device capable of chiral discrimination.…”
Section: 213mentioning
confidence: 66%
“…An attempt to combine this method with a fluorescent monomer has also been described. 499 Other hydroxyl group containing molecules have been imprinted using this method: nandrolone, 500 propofol, 501 other phenols and bis-phenol A. 484,485,502 This approach was also used in the preparation of mentholimprinted polymers by ring-opening metathesis polymerization (ROMP).…”
mentioning
confidence: 99%
“…This suggests that it should be possible to use relatively thick wave-guiding layers without completely sacrificing to mass sensitivity and hence, extend the range of wave-guide materials that can be used with layer guided acoustic sensors. Molecularly imprinted polymer materials (MIP) show potential for sensitising layers on acoustic wave devices (Percival et al 2001(Percival et al ,2002. However to the authors knowledge, there have been no reports of techniques for fabricating MIP films of controlled thickness in the range 0.1-5 µm required for operating in the first Love mode.…”
Section: Resultsmentioning
confidence: 99%
“…Esta é a estratégia de imobilização mais simples, e baseia-se no encapsulamento de partículas de MIP dentro de matrizes suportes, tais como géis 36 ou polímeros solúveis inertes 37,38 , para formar membranas que podem ser fixadas mecanicamente na superfície do transdutor. Os MIP ainda podem ser encapsulados como uma fina camada de partículas poliméricas, entre a superfície do transdutor e uma membrana inerte 39,40 .…”
Section: Imobilização Do Mip Por Oclusãounclassified