Molecular imprinting in Separation Science

Greibrokk, Tyge; Sellergren, Börje

doi:10.1002/jssc.200990072

Cited by 16 publications

(9 citation statements)

References 15 publications

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“…For this purpose, the polymers containing thymine groups were synthesized. In our previous research copolymer of (methacryloyl)aminopropyltrimethylammonium chloride and N ‐(acryloyloxyethyl)thymine (AM) and PAH polymers were used . In this paper, materials based on completely novel synthetic polyelectrolytes, i.e.…”

Section: Resultsmentioning

confidence: 99%

Selective adsorption of modified nucleoside cancer biomarkers by hybrid molecularly imprinted adsorbents

Iwanowska

Yusa

Nowakowska

et al. 2016

J of Separation Science

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Modified adenosine nucleosides have been proposed to be potential DNA-based biomarkers for early diagnosis of tumor and a promising tool for the development of noninvasive prediction systems. However, the low concentration of modified adenosine nucleosides in physiological fluids makes them challenging for both quantitative and qualitative determination. Therefore, materials, which are potentially useful for selective adsorption of nucleobase-containing compounds, were obtained. To obtain the adsorbents, the silica gel particles were coated layer-by-layer with films of the polymers with different combinations of polymers containing thymine groups. Next, the microspheres were irradiated with UV light in the presence of 2'-deoxyadenosine or 5'-deoxy-5'-(methylthio)adenosine, as template molecules, which resulted in the photodimerization of thymine moieties and molecular imprinting of adsorbed modified adenosine compounds. The selectivity of the adsorption was significantly enhanced by the photoimprinting process. Eventually, the imprinted particles have shown an improved ability to recognize mainly 2'-deoxyadenosine and 5'-deoxy-5'-(methylthio)adenosine molecules. The best performing adsorbent was obtained using modified natural polysaccharides. The studied materials could serve as promising adsorbents of biomarkers for tumor diagnostics.

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Section: Resultsmentioning

confidence: 99%

Selective adsorption of modified nucleoside cancer biomarkers by hybrid molecularly imprinted adsorbents

Iwanowska

Yusa

Nowakowska

et al. 2016

J of Separation Science

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“…When pH increases from an acidic value to a neutral value, various hydrolyzed species exist in equilibrium with UO 2 2+ as given in the Eqs. (5)- (7). Monovalent uranyl species dominates at higher pH (4.0-6.0) and UO 2 2+ at low pH (2.0) [29,30].…”

Section: Optimization Studiesmentioning

confidence: 99%

“…They are remarkably stable against mechanical stresses, high temperatures and pressures, intense radiation and a range of organic solvents, resistant against treatment with acid or base [7]. Bulk polymerization is the most commonly used imprinting technique, but is not amenable to scale up and it has to be grounded and sieved to generate particles of approximately 10-20 m. This produces highly irregular particles with a loss of up to 80% of the material, the greatest disadvantage being the inaccessible binding sites situated deep inside the bulk of the polymer matrix.…”

Section: Introductionmentioning

confidence: 99%

“…Imprinting is the molding of complimentary binding sites for target molecules into synthetic polymers [7], which relies on the formation of a cross linked polymer in the presence of template [8]. They are remarkably stable against mechanical stresses, high temperatures and pressures, intense radiation and a range of organic solvents, resistant against treatment with acid or base [7].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of surface imprinted nanospheres for selective removal of uranium from simulants of Sambhar salt lake and ground water

Milja¹,

Prathish²,

Rao³

2011

Journal of Hazardous Materials

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“…13 To date, MIPs have found a wide range of applications in various fields, such as in separations, biosensors, catalysis, medical diagnostics and drug delivery. [14][15][16] As a low-cost apparatus and direct analytical technique for high sensitivity, good selectivity and rapid identification of different molecules ranging from small molecules to biomacromolecules, 17,18 electrochemical sensors are widely used in molecular imprinting technology. 19,20 Electrochemical polymerization is often used due to its simple operation and high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

A Study of Electrochemical Sensor Based on BHb-imprinted Magnetic Nanoparticles

Huang

Wang

et al. 2017

ANAL. SCI.

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A study of an electrochemical sensor based on bovine hemoglobin (BHb) imprinted magnetic nanoparticles (MIPs) was investigated. First, BHb MIPs were successfully synthesized with magnetic Fe3O4@Au nanoparticles as carrier by surface modification of mercapto propionic acid for introducing carboxyl groups, combined with dopamine as the functional monomer and BHb as the template protein. Then, the MIPs were modified to the surface of a glassy carbon electrode (GCE) for electrochemical analysis by using cyclic voltammetry in the potassium ferricyanide solution. Results show that there was a good dynamic response between electrochemical signals and the adsorption amount of protein in the range of 0.05 to 0.5 mg mL -1 . Results show that the sensor exhibits a significant specific recognition toward the template protein via selective test and can be used for analysis of serum samples. The synthesized MIPs are suitable for the removal and enrichment of template protein in proteomics. At the same time, the proposed electrochemical sensor can be used for recognition of BHb.

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Molecular imprinting in Separation Science

Cited by 16 publications

References 15 publications

Selective adsorption of modified nucleoside cancer biomarkers by hybrid molecularly imprinted adsorbents

Selective adsorption of modified nucleoside cancer biomarkers by hybrid molecularly imprinted adsorbents

Synthesis of surface imprinted nanospheres for selective removal of uranium from simulants of Sambhar salt lake and ground water

A Study of Electrochemical Sensor Based on BHb-imprinted Magnetic Nanoparticles

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