Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents

Crystal structure of N,N-dimethyl-N′-(2-methyl-4-oxo-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)formimidamide, C14H18N4OS

“…agents is limited due to the rapidly developing drug resistance in conjunction with the unsatisfactory status of present treatments of bacterial and fungal infections [3,4]. Pyrimidine nucleus has gained potential importance in medicinal chemistry, as some of its derivatives exhibited a wide range of biological activities, such as antiviral [5][6][7][8], anticoccidials [9,10], antimicrobial [11][12][13][14], antitumor [15][16][17][18], herbicidal, antileukemic [19,20], pesticides [21], CNS agents [22], tuberculostatic [23][24][25], antileishmanial [26][27][28], radioprotectant [29], anti-in ammatory [30], and cardiovascular activities [31,32]. The biological signicance of the above heterocycle prompted us to explore the synthesis of novel pyrimidines from 3-amino-2-methyl-5,6, 7,8-tetrahydrobenzo [4,5] The asymmetric unit of the title compound contains one independent molecule.…”

Synthesis and Biological Activity of Pyrazolo[3,4-d]pyrimidine Derivatives Containing 1,3,4-Thiadiazole

“…[1～3] 、抗病 毒 [4] 、抗菌 [5,6] 和抗炎 [7] 等, 也有不少关于农药活性方面 的报道 [8～10] , 故该类化合物已引起药物学家和农药化学 家 的 广 泛 关 注 . 1,3,4-噻 二 唑 类 化 合 物 由 于 具 有 杀 菌 [11,12] 、杀虫 [13] 、除草 [14,15] 和调节植物生长 [16～18] 等广泛 的生物活性而倍受青睐, 而且硫醚类化合物也是一类具 有抗菌活性的化合物 [11,19] .…”

Synthesis and Biological Activities of Novel 1,7-dihydropyrazolo[3,4-d]imidazo[1,2-f]pyrimidines

“…This later reacts then with substituted hydrazine to give the aminocyanopyrazole 2. Treatment of 2 with orthoester in the presence of catalytic amount of acid furnished the corresponding cyano-pyrazoloimidates 3 which subsequently were transformed to the corresponding amino pyrazolopyrimidines 4 upon treatment with ammoniac [5,[15][16][17]. Reaction of compound 4 with α-bromoacetophenone in the presence of a catalytic amount of PTSA (5 mol% The reaction occurs by a primary amino group intercepts a bromine atom liberating HBr, followed by an intracyclisation and elimination of a water molecule to give 1,7-dihydropyrazolo [3,4-d]imidazo[1,2-f] pyrimidines 5a-i.…”